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Salvesen lab authors past and present are in bold.

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Publications
2012 Publications
Aleshin AE, Drag M, Gombosuren N, Wei G, Mikolajczyk J, Satterthwait AC, Strongin AY, Liddington RC, Salvesen GS.
Activity, Specificity, and Probe Design for the Smallpox Virus Protease K7L.
J Biol Chem. 2012 Nov 16;287(47):39470-9.
PMID:23012361
Salvesen GS, Bogyo M.
Highlight: the universe of proteolytic networks and mechanisms.
Biol Chem. 2012 Sep;393(9):841.
PMID:22944685
van Raam BJ, Ehrnhoefer DE, Hayden MR, Salvesen GS.
Intrinsic cleavage of receptor-interacting protein kinase-1 by caspase-6.
Cell Death Differ. 2012 Aug 3.
PMID:22858542
Conus S, Pop C, Snipas SJ, Salvesen GS, Simon HU.
Cathepsin D primes caspase-8 activation by multiple intra-chain proteolysis.
J Biol Chem. 2012 Jun 15;287(25):21142-51.
PMID:22528489
Rickert RC, Salvesen GS, Ware CF.
Mousing around with caspases and IAPs.
Biochem J. 2012 Apr 15;443(2):e1-2.
PMID:22452818
Edgington LE, van Raam BJ, Verdoes M, Wierschem C, Salvesen GS, Bogyo M.
An optimized activity-based probe for the study of caspase-6 activation.
Chem Biol. 2012 Mar 23;19(3):340-52. 
PMID:22444589
Bender CE, Fitzgerald P, Tait SW, Llambi F, McStay GP, Tupper DO, Pellettieri J, Sánchez Alvarado A, Salvesen GS, Green DR.
Mitochondrial pathway of apoptosis is ancestral in metazoans.
Proc Natl Acad Sci U S A. 2012 Mar 27;109(13):4904-9.
PMID:22416118
Poreba M, McGowan S, Skinner-Adams TS, Trenholme KR, Gardiner DL, Whisstock JC, To J, Salvesen GS, Dalton JP, Drag M.
Fingerprinting the substrate specificity of M1 and M17 aminopeptidases of human malaria, Plasmodium falciparum.
PLoS One. 2012;7(2):e31938.
PMID:22359643
Hachmann J, Snipas SJ, van Raam BJ, Cancino EM, Houlihan EJ, Poreba M, Kasperkiewicz P, Drag M, Salvesen GS.
Mechanism and specificity of the human paracaspase MALT1.
Biochem J. 2012 Apr 1;443(1):287-95.
PMID:22309193
Dobrotă C, Fasci D, Hădade ND, Roiban GD, Pop C, Meier VM, Dumitru I, Matache M, Salvesen GS, Funeriu DP.
Glycine fluoromethylketones as SENP-specific activity based probes.
Chembiochem. 2012 Jan 2;13(1):80-4.
PMID:22134988
Poreba M, Gajda A, Picha J, Jiracek J, Marschner A, Klein CD, Salvesen GS, Drag M.
S1 pocket fingerprints of human and bacterial methionine aminopeptidases determined using fluorogenic libraries of substrates and phosphorus based inhibitors.
Biochimie. 2012 Mar;94(3):704-10.
PMID:22085501
2011 Publications
Salvesen GS, Ashkenazi A.
Snapshot: caspases.
Cell. 2011 Oct 14;147(2):476-476.e1. No abstract available.
PMID:22000022
Green DR, Oberst A, Dillon CP, Weinlich R, Salvesen GS.
RIPK-dependent necrosis and its regulation by caspases: a mystery in five acts.
Mol Cell. 2011 Oct 7;44(1):9-16.
PMID:21981915
Lu JV, Weist BM, van Raam BJ, Marro BS, Nguyen LV, Srinivas P, Bell BD, Luhrs KA, Lane TE, Salvesen GS, Walsh CM.
Complementary roles of Fas-associated death domain (FADD) and receptor interacting protein kinase-3 (RIPK3) in T-cell homeostasis and antiviral immunity.
Proc Natl Acad Sci U S A. 2011 Sep 13;108(37):15312-7. Epub 2011 Aug 29.
PMID:21876153
van Raam BJ, Salvesen GS.
Proliferative versus apoptotic functions of caspase-8 Hetero or homo: The caspase-8 dimer controls cell fate.
Biochim Biophys Acta. 2011 Jun 16. [Epub ahead of print]
PMID:21704196
Albrow VE, Ponder EL, Fasci D, Békés M, Deu E, Salvesen GS, Bogyo M.
Development of small molecule inhibitors and probes of human SUMO deconjugating proteases.
Chem Biol. 2011 Jun 24;18(6):722-32.
PMID:21700208
Ponder EL, Albrow VE, Leader BA, Békés M, Mikolajczyk J, Fonović UP, Shen A, Drag M, Xiao J, Deu E, Campbell AJ, Powers JC, Salvesen GS, Bogyo M.
Functional characterization of a SUMO deconjugating protease of Plasmodium falciparum using newly identified small molecule inhibitors.
Chem Biol. 2011 Jun 24;18(6):711-21.
PMID:21700207
Akpan N, Serrano-Saiz E, Zacharia BE, Otten ML, Ducruet AF, Snipas SJ, Liu W, Velloza J, Cohen G, Sosunov SA, Frey WH 2nd, Salvesen GS, Connolly ES Jr, Troy CM.
Intranasal delivery of caspase-9 inhibitor reduces caspase-6-dependent axon/neuron loss and improves neurological function after stroke.
J Neurosci. 2011 Jun 15;31(24):8894-904.
PMID:21677173
Timmer JC, Salvesen GS.
N-terminomics: a high-content screen for protease substrates and their cleavage sites.
Methods Mol Biol. 2011;753:243-55.
PMID:21604127
Oberst A, Dillon CP, Weinlich R, McCormick LL, Fitzgerald P, Pop C, Hakem R, Salvesen GS, Green DR.
Catalytic activity of the caspase-8-FLIP(L) complex inhibits RIPK3-dependent necrosis.
Nature. 2011 Mar 17;471(7338):363-7. Epub 2011 Mar 2.
PMID:21368763
Zervoudi E, Papakyriakou A, Georgiadou D, Evnouchidou I, Gajda A, Poreba M, Salvesen GS, Drag M, Hattori A, Swevers L, Vourloumis D, Stratikos E.
Probing the S1 specificity pocket of the aminopeptidases that generate antigenic peptides.
Biochem J. 2011 Apr 15;435(2):411-20.
PMID:21314638
Békés M, Prudden J, Srikumar T, Raught B, Boddy MN, Salvesen GS.
The dynamics and mechanism of sumo chain deconjugation by SUMO-specific proteases.
J Biol Chem. 2011 Jan 20.
PMID: 21247896
Petroski MD, Salvesen GS, Wolf DA.
Urm1 couples sulfur transfer to ubiquitin-like protein function in oxidative stress.
Proc Natl Acad Sci U S A. 2011 Jan 18.
PMID: 21245332
Pop C, Oberst A, Drag M, van Raam BJ, Riedl SJ, Green DR, Salvesen GS.
FLIPL induces caspase 8 activity in the absence of interdomain caspase 8 cleavage and alters substrate specificity.
Biochem J. 2011 Jan 14;433(3):447-57.
PMID: 21235526
2010 Publications
Leyva MJ, Degiacomo F, Kaltenbach LS, Holcomb J, Zhang N, Gafni J, Park H, Lo DC, Salvesen GS, Ellerby LM, Ellman JA.
Identification and evaluation of small molecule pan-caspase inhibitors in Huntington's disease models.
Chem Biol. 2010 Nov 24;17(11):1189-200.
PMID: 21095569
Chekeni FB, Elliott MR, Sandilos JK, Walk SF, Kinchen JM, Lazarowski ER, Armstrong AJ, Penuela S, Laird DW, Salvesen GS, Isakson BE, Bayliss DA, Ravichandran KS.
Pannexin 1 channels mediate 'find-me' signal release and membrane permeability during apoptosis.
Nature. 2010 Oct 14;467(7317):863-7.
PMID: 20944749
Bratton SB, Salvesen GS.
Regulation of the Apaf-1-caspase-9 apoptosome.
J Cell Sci. 2010 Oct 1;123(Pt 19):3209-14.
PMID: 20844150
Shu CW, Drag M, Bekes M, Zhai D, Salvesen GS, Reed JC.
Synthetic substrates for measuring activity of autophagy proteases: autophagins (Atg4).
Autophagy. 2010 Oct 1;6(7):936-47. Epub 2010 Oct 19.
PMID: 20818167
Drag M, Salvesen GS.
Emerging principles in protease-based drug discovery.
Nat Rev Drug Discov. 2010 Sep;9(9):690-701. Review.
PMID: 20811381
Wachmann K, Pop C, van Raam BJ, Drag M, Mace PD, Snipas SJ, Zmasek C, Schwarzenbacher R, Salvesen GS, Riedl SJ.
Activation and specificity of human caspase-10.
Biochemistry. 2010 Sep 28;49(38):8307-15.
PMID: 20795673
Nakamura T, Wang L, Wong CC, Scott FL, Eckelman BP, Han X, Tzitzilonis C, Meng F, Gu Z, Holland EA, Clemente AT, Okamoto S, Salvesen GS, Riek R, Yates JR 3rd, Lipton SA.
Transnitrosylation of XIAP regulates caspase-dependent neuronal cell death.
Mol Cell. 2010 Jul 30;39(2):184-95.
PMID: 20670888
Enoksson M, Salvesen GS.
Metacaspases are not caspases--always doubt.
Cell Death Differ. 2010 Aug;17(8):1221. No abstract available.
PMID: 20622886
Oberst A, Pop C, Tremblay AG, Blais V, Denault JB, Salvesen GS, Green DR.
Inducible dimerization and inducible cleavage reveal a requirement for both processes in caspase-8 activation.
J Biol Chem. 2010 May 28;285(22):16632-42. Epub 2010 Mar 22.
PMID: 20308068
Grzywa R, Oleksyszyn J, Salvesen GS, Drag M.
Identification of very potent inhibitor of human aminopeptidase N (CD13).
Bioorg Med Chem Lett. 2010 Apr 15;20(8):2497-9. Epub 2010 Mar 4.PMID: 20307982
van Raam BJ, Salvesen GS.
Transferring death: a role for tRNA in apoptosis regulation.
Mol Cell. 2010 Mar 12;37(5):591-2.
PMID: 20227362
Staflin K, Krueger JS, Hachmann J, Forsyth JS, Lorger M, Steiniger SC, Mee J, Pop C, Salvesen GS, Janda KD, Felding-Habermann B.
Targeting activated integrin alphavbeta3 with patient-derived antibodies impacts late-stage multiorgan metastasis.
Clin Exp Metastasis. 2010 Apr;27(4):217-31. Epub 2010 Mar 12.
PMID: 20225083
Zhai D, Yu E, Jin C, Welsh K, Shiau CW, Chen L, Salvesen GS, Liddington R, Reed JC.
Vaccinia virus protein F1L is a caspase-9 inhibitor.
J Biol Chem. 2010 Feb 19;285(8):5569-80. Epub 2009 Dec 18.
PMID: 20022954
Drag M, Bogyo M, Ellman JA, Salvesen GS.
Aminopeptidase fingerprints, an integrated approach for identification of good substrates and optimal inhibitors.
J Biol Chem. 2010 Jan 29;285(5):3310-8. Epub 2009 Nov 30.
PMID: 19948737
2009 Publications
Walters J, Pop C, Scott FL, Drag M, Swartz P, Mattos C, Salvesen GS, Clark AC.
A constitutively active and uninhibitable caspase-3 zymogen efficiently induces apoptosis.
Biochem J. 2009 Dec 10;424(3):335-45.
PMID: 19788411
Timmer JC, Zhu W, Pop C, Regan T, Snipas SJ, Eroshkin AM, Riedl SJ, Salvesen GS.
Structural and kinetic determinants of protease substrates.
Nat Struct Mol Biol. 2009 Sep 20.
PMID: 19767749
Salvesen GS, Riedl SJ.
Structure of the Fas/FADD complex: A conditional death domain complex mediating signaling by receptor clustering.
Cell Cycle. 2009 Sep 30;8(17).
PMID: 19652545
Pop C, Salvesen GS.
Human caspases: activation, specificity, and regulation.
J Biol Chem
. 2009 Aug 14;284(33):21777-81. Epub 2009 May 26.
PMID: 19473994
Békés M, Salvesen GS.
The CULt of caspase-8 ubiquitination.
Cell
. 2009 May 15;137(4):604-6.
PMID: 19450509
Zhu S, Goeres J, Sixt KM, Békés M, Zhang XD, Salvesen GS, Matunis MJ.
Protection from isopeptidase-mediated deconjugation regulates paralog-selective sumoylation of RanGAP1.
Mol Cell
. 2009 Mar 13;33(5):570-80.
PMID: 19285941
Scott FL, Stec B, Pop C, Dobaczewska MK, Lee JJ, Monosov E, Robinson H, Salvesen GS, Schwarzenbacher R, Riedl SJ.
The Fas-FADD death domain complex structure unravels signalling by receptor clustering.
Nature. 2009 Feb 19;457(7232):1019-22. Epub 2008 Dec 31.
PMID: 19118384
Timmer AM, Timmer JC, Pence MA, Hsu LC, Ghochani M, Frey TG, Karin M, Salvesen GS, Nizet V.
Streptolysin o promotes group a streptococcus immune evasion by accelerated macrophage apoptosis.
J Biol Chem. 2009 Jan 9;284(2):862-71. Epub 2008 Nov 11.
PMID: 19001420
2008 Publications
Enoksson M, Salvesen GS.
Proteolytic needles in the cellular haystack.
Nat Chem Biol. 2008 Nov;4(11):651-2.
PMID: 18936746
Drag M, Salvesen GS.
DeSUMOylating enzymes-SENPs.
IUBMB Life. 2008 Jul 29. [Epub ahead of print]
PMID: 18666185
Pop C, Salvesen GS, Scott FL.
Chapter 21 caspase assays: identifying caspase activity and substrates in vitro and in vivo.
Methods Enzymol. 2008;446:351-67.
PMID: 18603133
Droga-Mazovec G, Bojic L, Petelin A, Ivanova S, Romih R, Repnik U, Salvesen GS, Stoka V, Turk V, Turk B.
Cysteine cathepsins trigger caspase-dependent cell death through cleavage of bid and antiapoptotic Bcl-2 homologues.
J Biol Chem. 2008 Jul 4;283(27):19140-50.
PMID: 18469004
Scott FL, Fuchs GJ, Boyd SE, Denault JB, Hawkins CJ, Dequiedt F, Salvesen GS.
Caspase-8 cleaves histone deacetylase 7 and abolishes its transcription repressor function.
J Biol Chem. 2008 Jul 11;283(28):19499-510.
PMID: 18458084
Salvesen GS, Riedl SJ.
Caspase mechanisms.
Adv Exp Med Biol. 2008;615:13-23. Review.
PMID: 18437889
Snipas SJ, Drag M, Stennicke HR, Salvesen GS.
Activation mechanism and substrate specificity of the Drosophila initiator caspase DRONC.
Cell Death Differ. 2008 Feb 29;
PMID: 18309328
Eckelman BP, Drag M, Snipas SJ, Salvesen GS.
The mechanism of peptide-binding specificity of IAP BIR domains.
Cell Death Differ. 2008 Feb 1;
PMID: 18239672
Denault JB, Salvesen GS.
Apoptotic caspase activation and activity.
Methods Mol Biol. 2008;414:191-220. Review.
PMID: 18175821
McStay GP, Salvesen GS, Green DR.
Overlapping cleavage motif selectivity of caspases: implications for analysis of apoptotic pathways.
Cell Death Differ. 2008 Feb;15(2):322-31.
PMID: 17975551
Drag M, Mikolajczyk J, Krishnakumar IM, Huang Z, Salvesen GS.
Activity profiling of human deSUMOylating enzymes (SENPs) with synthetic substrates suggests an unexpected specificity of two newly characterized members of the family.
Biochem J. 2008 Jan 15;409(2):461-9.
PMID: 17916063
2007 Publications
Denault JB, Drag M, Salvesen GS, Alves J, Heidt AB, Deveraux Q, Harris JL.   
Small molecules not direct activators of caspases.
Nat Chem Biol. 2007 Sep;3(9):519; author reply 520. N
PMID: 17710090
Truscott M, Denault JB, Goulet B, Leduy L, Salvesen GS, Nepveu A.   
Carboxy-terminal proteolytic processing of CUX1 by a caspase enables transcriptional activation in proliferating cells.
J Biol Chem. 2007 Aug 6;
PMID: 17681953
Wu YI, Munshi HG, Snipas SJ, Salvesen GS, Fridman R, Stack MS.   
Activation-coupled membrane-type 1 matrix metalloproteinase membrane trafficking.
Biochem J. 2007 Oct 15;407(2):171-7.
PMID: 17650075
Timmer JC, Enoksson M, Wildfang E, Zhu W, Igarashi Y, Denault JB, Ma Y, Dummitt B, Chang YH, Mast AE, Eroshkin A, Smith JW, Tao WA, Salvesen GS.    
Profiling constitutive proteolytic events in vivo.
Biochem J. 2007 Oct 1;407(1):41-8.
PMID: 17650073
Mikolajczyk J, Drag M, Bekes M, Cao JT, Ronai Z, Salvesen GS.   
Small Ubiquitin-related Modifier (SUMO)-specific Proteases: PROFILING THE SPECIFICITIES AND ACTIVITIES OF HUMAN SENPs.
J Biol Chem. 2007 Sep 7;282(36):26217-24. Epub 2007 Jun 25.
PMID: 17591783
Enoksson M, Li J, Ivancic MM, Timmer JC, Wildfang E, Eroshkin A, Salvesen GS, Tao WA.   
Identification of Proteolytic Cleavage Sites by Quantitative Proteomics.
J Proteome Res. 2007 Jun 5;
PMID: 17547438
Riedl SJ, Salvesen GS.
The apoptosome: signalling platform of cell death.
Nat Rev Mol Cell Biol. 2007 Mar 21;
PMID: 17377525
Pop C, Fitzgerald P, Green DR, Salvesen GS.
Role of Proteolysis in Caspase-8 Activation and Stabilization.
Biochemistry. 2007 Mar 20;
PMID: 17371051
2006 Publications
Timmer JC, Salvesen GS.
Caspase substrates.
Cell Death Differ. 2006 Nov 3;
PMID: 17082814
Dobo J, Swanson R, Salvesen GS, Olson ST, Gettins PG. 
CrmA inhibition of initiator caspases results in covalent complex formation and dissociation of the caspase tetramer.
J Biol Chem. 2006 Oct 19;
PMID: 17052983
Eckelman BP, Salvesen GS, Scott FL.    Related Articles, Links
Human inhibitor of apoptosis proteins: why XIAP is the black sheep of the family.
EMBO Rep. 2006 Oct;7(10):988-94.
PMID: 17016456
Ekici OD, Li ZZ, Campbell AJ, James KE, Asgian JL, Mikolajczyk J, Salvesen GS, Ganesan R, Jelakovic S, Grutter MG, Powers JC.   
Design, synthesis, and evaluation of aza-peptide Michael acceptors as selective and potent inhibitors of caspases-2, -3, -6, -7, -8, -9, and -10.
J Med Chem. 2006 Sep 21;49(19):5728-49.
PMID: 16970398
Denault JB, Bekes M, Scott FL, Sexton KM, Bogyo M, Salvesen GS
Engineered hybrid dimers: tracking the activation pathway of caspase-7.
Mol Cell. 2006 Aug;23(4):523-33.
PMID: 16916640
Berger AB, Witte MD, Denault JB, Sadaghiani AM, Sexton KM, Salvesen GS, Bogyo M.   
Identification of early intermediates of caspase activation using selective inhibitors and activity-based probes.
Mol Cell. 2006 Aug;23(4):509-21.
PMID: 16916639
Pop C, Timmer J, Sperandio S, Salvesen GS.
The apoptosome activates caspase-9 by dimerization. 
Mol Cell. 2006 Apr 21;22(2):269-75.
PMID: 16630894
Brendan P. Eckelman and Guy S. Salvesen
The Human Anti-apoptotic Proteins cIAP1 and cIAP2 Bind but Do Not Inhibit Caspases
J. Biol. Chem. 2006 281: 3254-3260.  First Published on December 8, 2005; doi:10.1074/jbc.M510863200
2005 Publications
Maryla Krajewska, Hoguen Kim, Eunah Shin, Susan Kennedy, Michael J. Duffy, Yick F. Wong, David Marr, Jowita Mikolajczyk, Ahmed Shabaik, Ivo Meinhold-Heerlein, Xianshu Huang, Steven Banares, Hirad Hedayat, John C. Reed, and Stan Krajewski
Tumor-Associated Alterations in Caspase-14 Expression in Epithelial Malignancies

Clin Cancer Res 2005 11: 5462-5471.
Simonovic M, Denault JB, Salvesen GS, Volz K, Gettins PG.
Lack of involvement of strand s1'A of the viral serpin CrmA in anti-apoptotic or caspase-inhibitory functions.
Arch Biochem Biophys. 2005 Aug 1;440(1):1-9.
PMID: 15993378
Fiona L Scott, Jean-Bernard Denault, Stefan J Riedl, Hwain Shin, Martin Renatus, and Guy S Salvesen
XIAP inhibits caspase-3 and -7 using two binding sites: evolutionarily conserved mechanism of IAPs
EMBO J., Feb 2005; 24: 645 - 655.

2004 Publications
Snipas SJ,Wildfang E, Nazif T, Christensen L,Boatright KM,Bogyo M,Stennicke HR, Salvesen GS.
Characteristics of the caspase-like catalytic domain of human paracaspase.
Biological Chemistry 2004 Nov;385 1093-1098. 
Vucic D, Franklin MC, Wallweber HJ, Das K, Eckelman BP, Shin H, Elliott LO, Kadkhodayan S, Deshayes K, Salvesen G, Fairbrother WJ.
Engineering ML-IAP to produce an extraordinarily potent caspase-9 inhibitor: implications for Smac-dependent anti-apoptotic activity of ML-IAP.
Biochem J. 2004 Oct 15
PMID: 15485396
Shin H, Renatus M, Eckelman BP, Nunes VA, Sampaio CA, Salvesen GS.
The BIR domain of IAP-like protein 2 is conformationally unstable: implications for caspase inhibition.
Biochem J. 2004 Oct 15
PMID: 15485395
Fuentes-Prior P, Salvesen GS.
The protein structures that shape caspase-activity, specificity, activation, and inhibition.
Biochem J. 2004 Sep 27; Pt
PMID: 15450003
Krajewska M, Rosenthal RE, Mikolajczyk J, Stennicke HR, Wiesenthal T, Mai J, Naito M, Salvesen GS, Reed JC, Fiskum G, Krajewski S.
Early processing of Bid and caspase-6, -8, -10, -14 in the canine brain during cardiac arrest and resuscitation.
Exp Neurol. 2004 Oct;189(2):261-79.
PMID: 15380478
Wilkinson JC, Wilkinson AS, Scott FL, Csomos RA, Salvesen GS, Duckett CS.
Neutralization of Smac/Diablo by IAPs: a caspase-independent mechanism for apoptotic inhibition.
J Biol Chem. 2004 Sep 15
PMID: 15371416
Mikolajczyk J, Scott FL, Krajewski S, Sutherlin DP, Salvesen GS.
Activation and substrate specificity of caspase-14.
Biochemistry. 2004 Aug 17;43(32):10560-9.
PMID: 15301553
Dohi T, Okada K, Xia F, Wilford CE, Samuel T, Welsh K, Marusawa H, Zou H, Armstrong R, Matsuzawa S, Salvesen GS, Reed JC, Altieri DC.
An IAP-IAP complex inhibits apoptosis.
J Biol Chem. 2004 Aug 13;279(33):34087-90.
PMID: 15218035
Boatright KM, Deis C, Denault JB, Sutherlin DP, Salvesen GS.
Activation of caspases-8 and -10 by FLIP(L).
Biochem J. 2004 Sep 1;382(Pt 2):651-7.
PMID: 15209560
Salvesen GS, Abrams JM.
Caspase activation - stepping on the gas or releasing the brakes? Lessons from humans and flies.
Oncogene. 2004 Apr 12;23(16):2774-84. Review.
PMID: 15077141
Denault JB, Boatright K.
Apoptosis in Biochemistry and Structural Biology.
3-8 February 2004, Keystone, CO, USA.
IDrugs. 2004 Apr;7(4):315-7.
PMID: 15057633
Ekici OD, Gotz MG, James KE, Li ZZ, Rukamp BJ, Asgian JL, Caffrey CR, Hansell E, Dvorak J, McKerrow JH, Potempa J, Travis J, Mikolajczyk J, Salvesen GS, Powers JC.
Aza-peptide Michael acceptors: a new class of inhibitors specific for caspases and other clan CD cysteine proteases.
J Med Chem. 2004 Apr 8;47(8):1889-92.
PMID: 15055989
James KE, Asgian JL, Li ZZ, Ekici OD, Rubin JR, Mikolajczyk J, Salvesen GS, Powers JC.
Design, synthesis, and evaluation of aza-peptide epoxides as selective and potent inhibitors of caspases-1, -3, -6, and -8.
J Med Chem. 2004 Mar 11;47(6):1553-74.
PMID: 14998341
Pedersen IM, Zapata JM, Samuel T, Scott FL, Salvesen GS, Honda T, Gribble GW, Suh N, Sporn MB, Kipps TJ, Reed JC.
Retraction: The triterpenoid CDDO-Imidazolide induces apoptosis and enhances fludarabine-induced apoptosis of CLL B-cells.
Blood. 2004 Aug 15;104(4):932. Epub 2004 Jan 22. No abstract available.
PMID: 14739219
Wu YI, Munshi HG, Sen R, Snipas SJ, Salvesen GS, Fridman R, Stack MS.
Glycosylation broadens the substrate profile of membrane type 1 matrix metalloproteinase.
J Biol Chem. 2004 Feb 27;279(9):8278-89.
PMID: 14670950
Cirman T, Oresic K, Mazovec GD, Turk V, Reed JC, Myers RM, Salvesen GS, Turk B.
Selective disruption of lysosomes in HeLa cells triggers apoptosis mediated by cleavage of Bid by multiple papain-like lysosomal cathepsins.
J Biol Chem. 2004 Jan 30;279(5):3578-87.
PMID: 14581476
2003 Publications
Boatright KM, Salvesen GS.
Mechanisms of caspase activation.
Curr Opin Cell Biol. 2003 Dec;15(6):725-31. Review.
PMID: 14644197
Boatright KM, Salvesen GS.
Caspase activation.
Biochem Soc Symp. 2003(70):233-42. Review.
PMID: 14587296
Ryan CA, Salvesen GS.
Caspases and neuronal development.
Biol Chem. 2003 Jun;384(6):855-61. Review.
PMID: 12887052
Kashkar H, Haefs C, Shin H, Hamilton-Dutoit SJ, Salvesen GS, Kronke M, Jurgensmeier JM.
XIAP-mediated caspase inhibition in Hodgkin's lymphoma-derived B cells.
J Exp Med. 2003 Jul 21;198(2):341-7.
PMID: 12874265
Denault JB, Salvesen GS.
Human caspase-7 activity and regulation by its N-terminal peptide.
J Biol Chem. 2003 Sep 5;278(36):34042-50.
PMID: 12824163
Shin H, Okada K, Wilkinson JC, Solomon KM, Duckett CS, Reed JC, Salvesen GS.
Identification of ubiquitination sites on the X-linked inhibitor of apoptosis protein.
Biochem J. 2003 Aug 1;373(Pt 3):965-71.
PMID: 12747801
Salvesen GS, Scott FL.
Serpins are getting hotter.
Structure (Camb). 2003 Apr;11(4):364-5. No abstract available.
PMID: 12679013
Boatright KM, Renatus M, Scott FL, Sperandio S, Shin H, Pedersen IM, Ricci JE, Edris WA, Sutherlin DP, Green DR, Salvesen GS.
A unified model for apical caspase activation.
Mol Cell. 2003 Feb;11(2):529-41.
PMID: 12620239
Mikolajczyk J, Boatright KM, Stennicke HR, Nazif T, Potempa J, Bogyo M, Salvesen GS.
Sequential autolytic processing activates the zymogen of Arg-gingipain.
J Biol Chem. 2003 Mar 21;278(12):10458-64. Epub 2003 Jan 17.
PMID: 12533545
2002 Publications
Denault JB, Salvesen GS.
Caspases: keys in the ignition of cell death.
Chem Rev. 2002 Dec;102(12):4489-500. Review. No abstract available.
PMID: 12475198
Salvesen GS.
Caspases and apoptosis.
Essays Biochem. 2002;38:9-19. Review.
PMID: 12463158
Asgian JL, James KE, Li ZZ, Carter W, Barrett AJ, Mikolajczyk J, Salvesen GS, Powers JC.
Aza-peptide epoxides: a new class of inhibitors selective for clan CD cysteine proteases.
J Med Chem. 2002 Nov 7;45(23):4958-60.
PMID: 12408706
Turk B, Turk D, Salvesen GS.
Regulating cysteine protease activity: essential role of protease inhibitors as guardians and regulators.
Curr Pharm Des. 2002;8(18):1623-37. Review.
PMID: 12132995
Troy CM, Salvesen GS.
Caspases on the brain.
J Neurosci Res. 2002 Jul 15;69(2):145-50. Review.
PMID: 12111795
Ryan CA, Stennicke HR, Nava VE, Burch JB, Hardwick JM, Salvesen GS.
Inhibitor specificity of recombinant and endogenous caspase-9.
Biochem J. 2002 Sep 1;366(Pt 2):595-601.
PMID: 12067274
Salvesen GS, Duckett CS.
IAP proteins: blocking the road to death's door.
Nat Rev Mol Cell Biol. 2002 Jun;3(6):401-10. Review.
PMID: 12042762
Lu C, Fu W, Salvesen GS, Mattson MP.
Direct cleavage of AMPA receptor subunit GluR1 and suppression of AMPA currents by caspase-3: implications for synaptic plasticity and excitotoxic neuronal death.
Neuromolecular Med. 2002;1(1):69-79.
PMID: 12025817
Gil-Parrado S, Fernandez-Montalvan A, Assfalg-Machleidt I, Popp O, Bestvater F, Holloschi A, Knoch TA, Auerswald EA, Welsh K, Reed JC, Fritz H, Fuentes-Prior P, Spiess E, Salvesen GS, Machleidt W.
Ionomycin-activated calpain triggers apoptosis. A probable role for Bcl-2 family members.
J Biol Chem. 2002 Jul 26;277(30):27217-26.
PMID: 12000759
Okamoto S, Li Z, Ju C, Scholzke MN, Mathews E, Cui J, Salvesen GS, Bossy-Wetzel E, Lipton SA.
Dominant-interfering forms of MEF2 generated by caspase cleavage contribute to NMDA-induced neuronal apoptosis.
Proc Natl Acad Sci U S A. 2002 Mar 19;99(6):3974-9.
PMID: 11904443
Salvesen GS, Renatus M.
Apoptosome: the seven-spoked death machine.
Dev Cell. 2002 Mar;2(3):256-7. Review.
PMID: 11879630
Stennicke HR, Ryan CA, Salvesen GS.
Reprieval from execution: the molecular basis of caspase inhibition.
Trends Biochem Sci. 2002 Feb;27(2):94-101. Review.
PMID: 11852247
Salvesen GS.
Caspases: opening the boxes and interpreting the arrows.
Cell Death Differ. 2002 Jan;9(1):3-5. No abstract available.
PMID: 11803369
2001 Publications
Riedl SJ, Fuentes-Prior P, Renatus M, Kairies N, Krapp S, Huber R, Salvesen GS, Bode W.
Structural basis for the activation of human procaspase-7.
Proc Natl Acad Sci U S A. 2001 Dec 18;98(26):14790-5.
PMID: 11752425
Renatus M, Stennicke HR, Scott FL, Liddington RC, Salvesen GS.
Dimer formation drives the activation of the cell death protease caspase 9.
Proc Natl Acad Sci U S A. 2001 Dec 4;98(25):14250-5.
PMID: 11734640
Riedl SJ, Renatus M, Snipas SJ, Salvesen GS.
Mechanism-based inactivation of caspases by the apoptotic suppressor p35.
Biochemistry. 2001 Nov 6;40(44):13274-80.
PMID: 11683637
Snipas SJ, Stennicke HR, Riedl S, Potempa J, Travis J, Barrett AJ, Salvesen GS.
Inhibition of distant caspase homologues by natural caspase inhibitors.
Biochem J. 2001 Jul 15;357(Pt 2):575-80.
PMID: 11439111
Silverman GA, Bird PI, Carrell RW, Church FC, Coughlin PB, Gettins PG, Irving JA, Lomas DA, Luke CJ, Moyer RW, Pemberton PA, Remold-O'Donnell E, Salvesen GS, Travis J, Whisstock JC.
The serpins are an expanding superfamily of structurally similar but functionally diverse proteins. Evolution, mechanism of inhibition, novel functions, and a revised nomenclature.
J Biol Chem. 2001 Sep 7;276(36):33293-6. Epub 2001 Jul 02. Review. No abstract available.
PMID: 11435447
Riedl SJ, Renatus M, Schwarzenbacher R, Zhou Q, Sun C, Fesik SW, Liddington RC, Salvesen GS.
Structural basis for the inhibition of caspase-3 by XIAP.
Cell. 2001 Mar 9;104(5):791-800.
PMID: 11257232
Salvesen GS.
A lysosomal protease enters the death scene.
J Clin Invest. 2001 Jan;107(1):21-2. Review. No abstract available.
PMID: 11134173
Leo E, Deveraux QL, Buchholtz C, Welsh K, Matsuzawa S, Stennicke HR, Salvesen GS, Reed JC.
TRAF1 is a substrate of caspases activated during tumor necrosis factor receptor-alpha-induced apoptosis.
J Biol Chem. 2001 Mar 16;276(11):8087-93.
PMID: 11098060
Stoka V, Turk B, Schendel SL, Kim TH, Cirman T, Snipas SJ, Ellerby LM, Bredesen D, Freeze H, Abrahamson M, Bromme D, Krajewski S, Reed JC, Yin XM, Turk V, Salvesen GS.
Lysosomal protease pathways to apoptosis. Cleavage of bid, not pro-caspases, is the most likely route.
J Biol Chem. 2001 Feb 2;276(5):3149-57.
PMID: 11073962
Affar EB, Germain M, Winstall E, Vodenicharov M, Shah RG, Salvesen GS, Poirier GG.
Caspase-3-mediated processing of poly(ADP-ribose) glycohydrolase during apoptosis.
J Biol Chem. 2001 Jan 26;276(4):2935-42.
PMID: 11053413
2000 Publications
Vucic D, Stennicke HR, Pisabarro MT, Salvesen GS, Dixit VM.
ML-IAP, a novel inhibitor of apoptosis that is preferentially expressed in human melanomas.
Curr Biol. 2000 Nov 2;10(21):1359-66.
PMID: 11084335
Stennicke HR, Renatus M, Meldal M, Salvesen GS.
Internally quenched fluorescent peptide substrates disclose the subsite preferences of human caspases 1, 3, 6, 7 and 8.
Biochem J. 2000 Sep 1;350 Pt 2:563-8.
PMID: 10947972
Zhou Q, Salvesen GS.
Viral caspase inhibitors CrmA and p35.
Methods Enzymol. 2000;322:143-54. No abstract available.
PMID: 10914011
Stennicke HR, Salvesen GS.
Caspase assays.
Methods Enzymol. 2000;322:91-100. No abstract available.
PMID: 10914007
Renatus M, Zhou Q, Stennicke HR, Snipas SJ, Turk D, Bankston LA, Liddington RC, Salvesen GS.
Crystal structure of the apoptotic suppressor CrmA in its cleaved form.
Structure Fold Des. 2000 Jul 15;8(7):789-97.
PMID: 10903953
Lu DC, Rabizadeh S, Chandra S, Shayya RF, Ellerby LM, Ye X, Salvesen GS, Koo EH, Bredesen DE.
A second cytotoxic proteolytic peptide derived from amyloid beta-protein precursor.
Nat Med. 2000 Apr;6(4):397-404.
PMID: 10742146
Stennicke HR, Salvesen GS.
Caspases - controlling intracellular signals by protease zymogen activation.
Biochim Biophys Acta. 2000 Mar 7;1477(1-2):299-306. Review.
PMID: 10708865
Huang Q, Deveraux QL, Maeda S, Salvesen GS, Stennicke HR, Hammock BD, Reed JC.
Evolutionary conservation of apoptosis mechanisms: lepidopteran and baculoviral inhibitor of apoptosis proteins are inhibitors of mammalian caspase-9.
Proc Natl Acad Sci U S A. 2000 Feb 15;97(4):1427-32.
PMID: 10677478
1999 Publications
Deveraux QL, Stennicke HR, Salvesen GS, Reed JC.
Endogenous inhibitors of caspases.
J Clin Immunol. 1999 Nov;19(6):388-98. Review.
PMID: 10634212
Stennicke HR, Salvesen GS.
Catalytic properties of the caspases.
Cell Death Differ. 1999 Nov;6(11):1054-9. Review.
PMID: 10578173
Salvesen GS.
Caspase 8: igniting the death machine.
Structure Fold Des. 1999 Oct 15;7(10):R225-9. Review.
PMID: 10545333
Deveraux QL, Leo E, Stennicke HR, Welsh K, Salvesen GS, Reed JC.
Cleavage of human inhibitor of apoptosis protein XIAP results in fragments with distinct specificities for caspases.
EMBO J. 1999 Oct 1;18(19):5242-51.
PMID: 10508158
Salvesen GS, Dixit VM.
Caspase activation: the induced-proximity model.
Proc Natl Acad Sci U S A. 1999 Sep 28;96(20):10964-7. Review.
PMID: 10500109
Germain M, Affar EB, D'Amours D, Dixit VM, Salvesen GS, Poirier GG.
Cleavage of automodified poly(ADP-ribose) polymerase during apoptosis. Evidence for involvement of caspase-7.
J Biol Chem. 1999 Oct 1;274(40):28379-84.
PMID: 10497198
Wolf BB, Goldstein JC, Stennicke HR, Beere H, Amarante-Mendes GP, Salvesen GS, Green DR.
Calpain functions in a caspase-independent manner to promote apoptosis-like events during platelet activation.
Blood. 1999 Sep 1;94(5):1683-92.
PMID: 10477693
Krajewski S, Krajewska M, Ellerby LM, Welsh K, Xie Z, Deveraux QL, Salvesen GS, Bredesen DE, Rosenthal RE, Fiskum G, Reed JC.
Release of caspase-9 from mitochondria during neuronal apoptosis and cerebral ischemia.
Proc Natl Acad Sci U S A. 1999 May 11;96(10):5752-7.
PMID: 10318956
Stennicke HR, Salvesen GS.
Caspases: preparation and characterization.
Methods. 1999 Apr;17(4):313-9.
PMID: 10196102
Salvesen GS.
Programmed cell death and the caspases.
APMIS. 1999 Jan;107(1):73-9. Review.
PMID: 10190282
Chou JJ, Li H, Salvesen GS, Yuan J, Wagner G.
Solution structure of BID, an intracellular amplifier of apoptotic signaling.
Cell. 1999 Mar 5;96(5):615-24.
PMID: 10089877
Ellerby LM, Andrusiak RL, Wellington CL, Hackam AS, Propp SS, Wood JD, Sharp AH, Margolis RL, Ross CA, Salvesen GS, Hayden MR, Bredesen DE.
Cleavage of atrophin-1 at caspase site aspartic acid 109 modulates cytotoxicity.
J Biol Chem. 1999 Mar 26;274(13):8730-6.
PMID: 10085113
Stennicke HR, Deveraux QL, Humke EW, Reed JC, Dixit VM, Salvesen GS.
Caspase-9 can be activated without proteolytic processing.
J Biol Chem. 1999 Mar 26;274(13):8359-62.
PMID: 10085063
Ellerby LM, Hackam AS, Propp SS, Ellerby HM, Rabizadeh S, Cashman NR, Trifiro MA, Pinsky L, Wellington CL, Salvesen GS, Hayden MR, Bredesen DE.
Kennedy's disease: caspase cleavage of the androgen receptor is a crucial event in cytotoxicity.
J Neurochem. 1999 Jan;72(1):185-95.
PMID: 9886069
1998 Publications
Amarante-Mendes GP, Finucane DM, Martin SJ, Cotter TG, Salvesen GS, Green DR.
Anti-apoptotic oncogenes prevent caspase-dependent and independent commitment for cell death.
Cell Death Differ. 1998 Apr;5(4):298-306.
PMID: 10200475
Miyashita T, Nagao K, Krajewski S, Salvesen GS, Reed JC, Inoue T, Yamada M.
Investigation of glucocorticoid-induced apoptotic pathway: processing of caspase-6 but not caspase-3.
Cell Death Differ. 1998 Dec;5(12):1034-41.
PMID: 9894610
Hu S, Snipas SJ, Vincenz C, Salvesen G, Dixit VM.
Caspase-14 is a novel developmentally regulated protease.
J Biol Chem. 1998 Nov 6;273(45):29648-53.
PMID: 9792675
Yang X, Stennicke HR, Wang B, Green DR, Janicke RU, Srinivasan A, Seth P, Salvesen GS, Froelich CJ.
Granzyme B mimics apical caspases. Description of a unified pathway for trans-activation of executioner caspase-3 and -7.
J Biol Chem. 1998 Dec 18;273(51):34278-83.
PMID: 9852092
Cardone MH, Roy N, Stennicke HR, Salvesen GS, Franke TF, Stanbridge E, Frisch S, Reed JC.
Regulation of cell death protease caspase-9 by phosphorylation.
Science. 1998 Nov 13;282(5392):1318-21.
PMID: 9812896
Mehlen P, Rabizadeh S, Snipas SJ, Assa-Munt N, Salvesen GS, Bredesen DE.
The DCC gene product induces apoptosis by a mechanism requiring receptor proteolysis.
Nature. 1998 Oct 22;395(6704):801-4.
PMID: 9796814
Stennicke HR, Jurgensmeier JM, Shin H, Deveraux Q, Wolf BB, Yang X, Zhou Q, Ellerby HM, Ellerby LM, Bredesen D, Green DR, Reed JC, Froelich CJ, Salvesen GS.
Pro-caspase-3 is a major physiologic target of caspase-8.
J Biol Chem. 1998 Oct 16;273(42):27084-90.
PMID: 9765224
Stennicke HR, Salvesen GS.
Properties of the caspases.
Biochim Biophys Acta. 1998 Sep 8;1387(1-2):17-31. Review.
PMID: 9748481
Zhou Q, Krebs JF, Snipas SJ, Price A, Alnemri ES, Tomaselli KJ, Salvesen GS.
Interaction of the baculovirus anti-apoptotic protein p35 with caspases. Specificity, kinetics, and characterization of the caspase/p35 complex.
Biochemistry. 1998 Jul 28;37(30):10757-65.
PMID: 9692966
Deveraux QL, Roy N, Stennicke HR, Van Arsdale T, Zhou Q, Srinivasula SM, Alnemri ES, Salvesen GS, Reed JC.
IAPs block apoptotic events induced by caspase-8 and cytochrome c by direct inhibition of distinct caspases.
EMBO J. 1998 Apr 15;17(8):2215-23.
PMID: 9545235
Wellington CL, Ellerby LM, Hackam AS, Margolis RL, Trifiro MA, Singaraja R, McCutcheon K, Salvesen GS, Propp SS, Bromm M, Rowland KJ, Zhang T, Rasper D, Roy S, Thornberry N, Pinsky L, Kakizuka A, Ross CA, Nicholson DW, Bredesen DE, Hayden MR.
Caspase cleavage of gene products associated with triplet expansion disorders generates truncated fragments containing the polyglutamine tract.
J Biol Chem. 1998 Apr 10;273(15):9158-67.
PMID: 9535906
Takahashi R, Deveraux Q, Tamm I, Welsh K, Assa-Munt N, Salvesen GS, Reed JC.
A single BIR domain of XIAP sufficient for inhibiting caspases.
J Biol Chem. 1998 Apr 3;273(14):7787-90.
PMID: 9525868
Zapata JM, Takahashi R, Salvesen GS, Reed JC.
Granzyme release and caspase activation in activated human T-lymphocytes.
J Biol Chem. 1998 Mar 20;273(12):6916-20.
PMID: 9506996
Muzio M, Stockwell BR, Stennicke HR, Salvesen GS, Dixit VM.
An induced proximity model for caspase-8 activation.
J Biol Chem. 1998 Jan 30;273(5):2926-30.
PMID: 9446604
1997 Publications
Roy N, Deveraux QL, Takahashi R, Salvesen GS, Reed JC.
The c-IAP-1 and c-IAP-2 proteins are direct inhibitors of specific caspases.
EMBO J. 1997 Dec 1;16(23):6914-25.
PMID: 9384571
Salvesen GS.
Serpins and programmed cell death.
Adv Exp Med Biol. 1997;425:177-83. Review. No abstract available.
PMID: 9433500
Salvesen GS, Dixit VM.
Caspases: intracellular signaling by proteolysis.
Cell. 1997 Nov 14;91(4):443-6. Review. No abstract available.
PMID: 9390553
Stennicke HR, Salvesen GS.
Biochemical characteristics of caspases-3, -6, -7, and -8.
J Biol Chem. 1997 Oct 10;272(41):25719-23.
PMID: 9325297
Caulin C, Salvesen GS, Oshima RG.
Caspase cleavage of keratin 18 and reorganization of intermediate filaments during epithelial cell apoptosis.
J Cell Biol. 1997 Sep 22;138(6):1379-94.
PMID: 9298992
Ellerby HM, Martin SJ, Ellerby LM, Naiem SS, Rabizadeh S, Salvesen GS, Casiano CA, Cashman NR, Green DR, Bredesen DE.
Establishment of a cell-free system of neuronal apoptosis: comparison of premitochondrial, mitochondrial, and postmitochondrial phases.
J Neurosci. 1997 Aug 15;17(16):6165-78.
PMID: 9236228
Cardone MH, Salvesen GS, Widmann C, Johnson G, Frisch SM.
The regulation of anoikis: MEKK-1 activation requires cleavage by caspases.
Cell. 1997 Jul 25;90(2):315-23.
PMID: 9244305
Perry DK, Smyth MJ, Stennicke HR, Salvesen GS, Duriez P, Poirier GG, Hannun YA.
Zinc is a potent inhibitor of the apoptotic protease, caspase-3. A novel target for zinc in the inhibition of apoptosis.
J Biol Chem. 1997 Jul 25;272(30):18530-3.
PMID: 9228015
Deveraux QL, Takahashi R, Salvesen GS, Reed JC.
X-linked IAP is a direct inhibitor of cell-death proteases.
Nature. 1997 Jul 17;388(6639):300-4.
PMID: 9230442
Zhou Q, Salvesen GS.
Activation of pro-caspase-7 by serine proteases includes a non-canonical specificity.
Biochem J. 1997 Jun 1;324 ( Pt 2):361-4.
PMID: 9182691
Zhou Q, Snipas S, Orth K, Muzio M, Dixit VM, Salvesen GS.
Target protease specificity of the viral serpin CrmA. Analysis of five caspases.
J Biol Chem. 1997 Mar 21;272(12):7797-800.
PMID: 9065443
Muzio M, Salvesen GS, Dixit VM.
FLICE induced apoptosis in a cell-free system. Cleavage of caspase zymogens.
J Biol Chem. 1997 Jan 31;272(5):2952-6.
PMID: 9006941
1996 Publications
Koloczek H, Banbula A, Salvesen GS, Potempa J.
Serpin alpha 1proteinase inhibitor probed by intrinsic tryptophan fluorescence spectroscopy.
Protein Sci. 1996 Nov;5(11):2226-35.
PMID: 8931141
Froelich CJ, Hanna WL, Poirier GG, Duriez PJ, D'Amours D, Salvesen GS, Alnemri ES, Earnshaw WC, Shah GM.
Granzyme B/perforin-mediated apoptosis of Jurkat cells results in cleavage of poly(ADP-ribose) polymerase to the 89-kDa apoptotic fragment and less abundant 64-kDa fragment.
Biochem Biophys Res Commun. 1996 Oct 23;227(3):658-65.
PMID: 8885990
Orth K, O'Rourke K, Salvesen GS, Dixit VM.
Molecular ordering of apoptotic mammalian CED-3/ICE-like proteases.
J Biol Chem. 1996 Aug 30;271(35):20977-80.
PMID: 8702858
Komiyama T, Gron H, Pemberton PA, Salvesen GS.
Interaction of subtilisins with serpins.
Protein Sci. 1996 May;5(5):874-82.
PMID: 8732759
Quan LT, Tewari M, O'Rourke K, Dixit V, Snipas SJ, Poirier GG, Ray C, Pickup DJ, Salvesen GS.
Proteolytic activation of the cell death protease Yama/CPP32 by granzyme B.
Proc Natl Acad Sci U S A. 1996 Mar 5;93(5):1972-6.
PMID: 8700869
Komiyama T, Quan LT, Salvesen GS.
Inhibition of cysteine and serine proteinases by the cowpox virus serpin CRMA.
Adv Exp Med Biol. 1996;389:173-6. Review. No abstract available.
PMID: 8861008
1995 Publications
Tewari M, Quan LT, O'Rourke K, Desnoyers S, Zeng Z, Beidler DR, Poirier GG, Salvesen GS, Dixit VM.
Yama/CPP32 beta, a mammalian homolog of CED-3, is a CrmA-inhibitable protease that cleaves the death substrate poly(ADP-ribose) polymerase.
Cell. 1995 Jun 2;81(5):801-9.
PMID: 7774019
Quan LT, Caputo A, Bleackley RC, Pickup DJ, Salvesen GS.
Granzyme B is inhibited by the cowpox virus serpin cytokine response modifier A.
J Biol Chem. 1995 May 5;270(18):10377-9.
PMID: 7737968
1993 Publications
Strittmatter WJ, Weisgraber KH, Huang DY, Dong LM, Salvesen GS, Pericak-Vance M, Schmechel D, Saunders AM, Goldgaber D, Roses AD.
Binding of human apolipoprotein E to synthetic amyloid beta peptide: isoform-specific effects and implications for late-onset Alzheimer disease.
Proc Natl Acad Sci U S A. 1993 Sep 1;90(17):8098-102.
PMID: 8367470
Strittmatter WJ, Saunders AM, Schmechel D, Pericak-Vance M, Enghild J, Salvesen GS, Roses AD.
Apolipoprotein E: high-avidity binding to beta-amyloid and increased frequency of type 4 allele in late-onset familial Alzheimer disease.
Proc Natl Acad Sci U S A. 1993 Mar 1;90(5):1977-81.
PMID: 8446617
1992 Publications
Ray CA, Black RA, Kronheim SR, Greenstreet TA, Sleath PR, Salvesen GS, Pickup DJ.
Viral inhibition of inflammation: cowpox virus encodes an inhibitor of the interleukin-1 beta converting enzyme.
Cell. 1992 May 15;69(4):597-604.
PMID: 1339309
Salvesen G, Quan LT, Enghild JJ, Snipas S, Fey GH, Pizzo SV.
Expression of a functional alpha-macroglobulin receptor binding domain in Escherichia coli.
FEBS Lett. 1992 Nov 23;313(2):198-202.
PMID: 1385222