2022 Publications
Colón Ortiz CK, Potenski AM, Johnson KV, Chen CW, Snipas SJ, Jean YY, Avrutsky MI, Troy CM.
Quantification of Immunostained Caspase-9 in Retinal Tissue.
J Vis Exp. 2022 Jul 25;(185):10.3791/64237. doi: 10.3791/64237. PMID: 35938825
Snipas SJ, Jappelli R, Torkamani A, Paternostro G, Salvesen GS.
Gain of function of a metalloproteinase associated with multiple myeloma, bicuspid aortic valve, and Von Hippel-Lindau syndrome.
Biochem J. 2022 Jul 29;479(14):1533-1542. doi: 10.1042/BCJ20220166. PMID: 35789254
Bibo-Verdugo B, Joglekar I, Karadi Giridhar MN, Ramirez ML, Snipas SJ, Clark AC, Poreba M, Salvesen GS.
Resurrection of an ancient inflammatory locus reveals switch to caspase-1 specificity on a caspase-4 scaffold.
J Biol Chem. 2022 Jun;298(6):101931. doi: 10.1016/j.jbc.2022.101931. Epub 2022 Apr 12.
PMID: 35427646
Bibo-Verdugo B, Salvesen GS.
Caspase mechanisms in the regulation of inflammation.
Mol Aspects Med. 2022 Mar 2;88:101085. doi: 10.1016/j.mam.2022.101085. Online ahead of print. PMID: 35248371 Review.
Quantification of Immunostained Caspase-9 in Retinal Tissue.
J Vis Exp. 2022 Jul 25;(185):10.3791/64237. doi: 10.3791/64237. PMID: 35938825
Snipas SJ, Jappelli R, Torkamani A, Paternostro G, Salvesen GS.
Gain of function of a metalloproteinase associated with multiple myeloma, bicuspid aortic valve, and Von Hippel-Lindau syndrome.
Biochem J. 2022 Jul 29;479(14):1533-1542. doi: 10.1042/BCJ20220166. PMID: 35789254
Bibo-Verdugo B, Joglekar I, Karadi Giridhar MN, Ramirez ML, Snipas SJ, Clark AC, Poreba M, Salvesen GS.
Resurrection of an ancient inflammatory locus reveals switch to caspase-1 specificity on a caspase-4 scaffold.
J Biol Chem. 2022 Jun;298(6):101931. doi: 10.1016/j.jbc.2022.101931. Epub 2022 Apr 12.
PMID: 35427646
Bibo-Verdugo B, Salvesen GS.
Caspase mechanisms in the regulation of inflammation.
Mol Aspects Med. 2022 Mar 2;88:101085. doi: 10.1016/j.mam.2022.101085. Online ahead of print. PMID: 35248371 Review.
2021 Publications
Digby Z, Tourlomousis P, Rooney J, Boyle JP, Bibo-Verdugo B, Pickering RJ, Webster SJ, Monie TP, Hopkins LJ, Kayagaki N, Salvesen GS, Warming S, Weinert L, Bryant CE.
Evolutionary loss of inflammasomes in the Carnivora and implications for the carriage of zoonotic infections.
Cell Rep. 2021 Aug 24;36(8):109614. doi: 10.1016/j.celrep.2021.109614.PMID: 34433041
Maluch I, Grzymska J, Snipas S, Salvesen GS, Drag M.
Evaluation of the effects of phosphorylation of synthetic peptide substrates on their cleavage by caspase-3 and -7.
Biochem J. 2021 May 26:BCJ20210255. doi: 10.1042/BCJ20210255. PMID: 34037204
Evolutionary loss of inflammasomes in the Carnivora and implications for the carriage of zoonotic infections.
Cell Rep. 2021 Aug 24;36(8):109614. doi: 10.1016/j.celrep.2021.109614.PMID: 34433041
Maluch I, Grzymska J, Snipas S, Salvesen GS, Drag M.
Evaluation of the effects of phosphorylation of synthetic peptide substrates on their cleavage by caspase-3 and -7.
Biochem J. 2021 May 26:BCJ20210255. doi: 10.1042/BCJ20210255. PMID: 34037204
2020 Publications
Rut W, Lv Z, Zmudzinski M, Patchett S, Nayak D, Snipas SJ, El Oualid F, Huang TT, Bekes M, Drag M, Olsen SK.
Activity profiling and crystal structures of inhibitor-bound SARS-CoV-2 papain-like protease: A framework for anti-COVID-19 drug design.
Sci Adv. 2020 Oct 16;6(42):eabd4596. doi: 10.1126/sciadv.abd4596. PMID: 33067239
Kasperkiewicz P, Hempel A, Janiszewski T, Kolt S, Snipas SJ, Drag M, Salvesen GS.
NETosis Occurs Independently of Neutrophil Serine Proteases.
J Biol Chem. 2020 Oct 15:jbc.RA120.015682. doi: 10.1074/jbc.RA120.015682 PMID: 33060201
Poreba M, Groborz K, Rut W, Pore M, Snipas SJ, Vizovisek M, Turk B, Kuhn P, Drag M, Salvesen GS.
Multiplexed probing of proteolytic enzymes using mass cytometry-compatible activity-based probes.
J Am Chem Soc. 2020 Sep 1. doi: 10.1021/jacs.0c06762. Online ahead of print.PMID: 32870676
Rut W, Zmudzinski M, Snipas SJ, Bekes M, Huang TT, Drag M.
Engineered unnatural ubiquitin for optimal detection of deubiquitinating enzymes.
Chem Sci. 2020 May 27;11(23):6058-6069. doi: 10.1039/d0sc01347a. eCollection 2020 Jun 21. PMID: 32953009
Corrigan TS, Lotti Diaz LM, Border SE, Ratigan SC, Kasper KQ, Sojka D, Fajtova P, Caffrey CR, Salvesen GS, McElroy CA, Hadad CM, Doğan Ekici Ö.
Design, synthesis, and in vitro evaluation of aza-peptide aldehydes and ketones as novel and selective protease inhibitors.
J Enzyme Inhib Med Chem. 2020 Dec;35(1):1387-1402. doi: 10.1080/14756366.2020.1781107.PMID: 32633155
Razai AS, Snipas SJ, Poreba M, Fasci D, Salvesen GS.
Engineering caspase 7 as an affinity reagent to capture proteolytic products.
FEBS J. 2020 Jul 3. doi: 10.1111/febs.15467. PMID: 32619291
Avrutsky MI, Ortiz CC, Johnson KV, Potenski AM, Chen CW, Lawson JM, White AJ, Yuen SK, Morales FN, Canepa E, Snipas S, Salvesen GS, Jean YY, Troy CM.
Endothelial activation of caspase-9 promotes neurovascular injury in retinal vein occlusion.
Nat Commun. 2020 Jun 23;11(1):3173. doi: 10.1038/s41467-020-16902-5.PMID: 32576823
Bibo-Verdugo B, Snipas SJ, Kolt S, Poreba M, Salvesen GS.
Extended subsite profiling of the pyroptosis effector protein gasdermin D reveals a region recognized by inflammatory caspase-11.
J Biol Chem. 2020 Aug 7;295(32):11292-11302. doi: 10.1074/jbc.RA120.014259. Epub 2020 Jun 18.PMID: 32554464
Tom I, Pham VC, Katschke KJ Jr, Li W, Liang WC, Gutierrez J, Ah Young A, Figueroa I, Eshghi ST, Lee CV, Kanodia J, Snipas SJ, Salvesen GS, Lai P, Honigberg L, van Lookeren Campagne M, Kirchhofer D, Baruch A, Lill JR.
Development of a therapeutic anti-HtrA1 antibody and the identification of DKK3 as a pharmacodynamic biomarker in geographic atrophy.
Proc Natl Acad Sci U S A. 2020 May 5;117(18):9952-9963. doi: 10.1073/pnas.1917608117. Epub 2020 Apr 28.PMID: 32345717
Minina EA, Staal J, Alvarez VE, Berges JA, Berman-Frank I, Beyaert R, Bidle KD, Bornancin F, Casanova M, Cazzulo JJ, Choi CJ, Coll NS, Dixit VM, Dolinar M, Fasel N, Funk C, Gallois P, Gevaert K, Gutierrez-Beltran E, Hailfinger S, Klemenčič M, Koonin EV, Krappmann D, Linusson A, Machado MFM, Madeo F, Megeney LA, Moschou PN, Mottram JC, Nyström T, Osiewacz HD, Overall CM, Pandey KC, Ruland J, Salvesen GS, Shi Y, Smertenko A, Stael S, Ståhlberg J, Suárez MF, Thome M, Tuominen H, Van Breusegem F, van der Hoorn RAL, Vardi A, Zhivotovsky B, Lam E, Bozhkov PV.
Classification and Nomenclature of Metacaspases and Paracaspases: No More Confusion with Caspases.
Mol Cell. 2020 Mar 5;77(5):927-929. doi: 10.1016/j.molcel.2019.12.020. No abstract available. PMID:32142688
Kołt S, Janiszewski T, Kaiserman D, Modrzycka S, Snipas SJ, Salvesen G, Drag M, Bird PI, Kasperkiewicz P.
Detection of Active Granzyme A in NK92 Cells with Fluorescent Activity-Based Probe.
J Med Chem. 2020 Mar 26;63(6):3359-3369. doi: 10.1021/acs.jmedchem.9b02042. Epub 2020 Mar 16.PMID:32142286
Razai AS, Eckelman BP, Salvesen GS.
Selective inhibition of matrix metalloproteinase 10 (MMP10) with a single-domain antibody.
J Biol Chem. 2020 Jan 17. pii: jbc.RA119.011712. PMID:31953328
Rut W, Lv Z, Zmudzinski M, Patchett S, Nayak D, Snipas SJ, El Oualid F, Huang TT, Bekes M, Drag M, Olsen SK.
Activity profiling and crystal structures of inhibitor-bound SARS-CoV-2 papain-like protease: A framework for anti-COVID-19 drug design.
Sci Adv. 2020 Oct 16;6(42):eabd4596. doi: 10.1126/sciadv.abd4596. PMID: 33067239
Kasperkiewicz P, Hempel A, Janiszewski T, Kolt S, Snipas SJ, Drag M, Salvesen GS.
NETosis Occurs Independently of Neutrophil Serine Proteases.
J Biol Chem. 2020 Oct 15:jbc.RA120.015682. doi: 10.1074/jbc.RA120.015682 PMID: 33060201
Poreba M, Groborz K, Rut W, Pore M, Snipas SJ, Vizovisek M, Turk B, Kuhn P, Drag M, Salvesen GS.
Multiplexed probing of proteolytic enzymes using mass cytometry-compatible activity-based probes.
J Am Chem Soc. 2020 Sep 1. doi: 10.1021/jacs.0c06762. Online ahead of print.PMID: 32870676
Rut W, Zmudzinski M, Snipas SJ, Bekes M, Huang TT, Drag M.
Engineered unnatural ubiquitin for optimal detection of deubiquitinating enzymes.
Chem Sci. 2020 May 27;11(23):6058-6069. doi: 10.1039/d0sc01347a. eCollection 2020 Jun 21. PMID: 32953009
Corrigan TS, Lotti Diaz LM, Border SE, Ratigan SC, Kasper KQ, Sojka D, Fajtova P, Caffrey CR, Salvesen GS, McElroy CA, Hadad CM, Doğan Ekici Ö.
Design, synthesis, and in vitro evaluation of aza-peptide aldehydes and ketones as novel and selective protease inhibitors.
J Enzyme Inhib Med Chem. 2020 Dec;35(1):1387-1402. doi: 10.1080/14756366.2020.1781107.PMID: 32633155
Razai AS, Snipas SJ, Poreba M, Fasci D, Salvesen GS.
Engineering caspase 7 as an affinity reagent to capture proteolytic products.
FEBS J. 2020 Jul 3. doi: 10.1111/febs.15467. PMID: 32619291
Avrutsky MI, Ortiz CC, Johnson KV, Potenski AM, Chen CW, Lawson JM, White AJ, Yuen SK, Morales FN, Canepa E, Snipas S, Salvesen GS, Jean YY, Troy CM.
Endothelial activation of caspase-9 promotes neurovascular injury in retinal vein occlusion.
Nat Commun. 2020 Jun 23;11(1):3173. doi: 10.1038/s41467-020-16902-5.PMID: 32576823
Bibo-Verdugo B, Snipas SJ, Kolt S, Poreba M, Salvesen GS.
Extended subsite profiling of the pyroptosis effector protein gasdermin D reveals a region recognized by inflammatory caspase-11.
J Biol Chem. 2020 Aug 7;295(32):11292-11302. doi: 10.1074/jbc.RA120.014259. Epub 2020 Jun 18.PMID: 32554464
Tom I, Pham VC, Katschke KJ Jr, Li W, Liang WC, Gutierrez J, Ah Young A, Figueroa I, Eshghi ST, Lee CV, Kanodia J, Snipas SJ, Salvesen GS, Lai P, Honigberg L, van Lookeren Campagne M, Kirchhofer D, Baruch A, Lill JR.
Development of a therapeutic anti-HtrA1 antibody and the identification of DKK3 as a pharmacodynamic biomarker in geographic atrophy.
Proc Natl Acad Sci U S A. 2020 May 5;117(18):9952-9963. doi: 10.1073/pnas.1917608117. Epub 2020 Apr 28.PMID: 32345717
Minina EA, Staal J, Alvarez VE, Berges JA, Berman-Frank I, Beyaert R, Bidle KD, Bornancin F, Casanova M, Cazzulo JJ, Choi CJ, Coll NS, Dixit VM, Dolinar M, Fasel N, Funk C, Gallois P, Gevaert K, Gutierrez-Beltran E, Hailfinger S, Klemenčič M, Koonin EV, Krappmann D, Linusson A, Machado MFM, Madeo F, Megeney LA, Moschou PN, Mottram JC, Nyström T, Osiewacz HD, Overall CM, Pandey KC, Ruland J, Salvesen GS, Shi Y, Smertenko A, Stael S, Ståhlberg J, Suárez MF, Thome M, Tuominen H, Van Breusegem F, van der Hoorn RAL, Vardi A, Zhivotovsky B, Lam E, Bozhkov PV.
Classification and Nomenclature of Metacaspases and Paracaspases: No More Confusion with Caspases.
Mol Cell. 2020 Mar 5;77(5):927-929. doi: 10.1016/j.molcel.2019.12.020. No abstract available. PMID:32142688
Kołt S, Janiszewski T, Kaiserman D, Modrzycka S, Snipas SJ, Salvesen G, Drag M, Bird PI, Kasperkiewicz P.
Detection of Active Granzyme A in NK92 Cells with Fluorescent Activity-Based Probe.
J Med Chem. 2020 Mar 26;63(6):3359-3369. doi: 10.1021/acs.jmedchem.9b02042. Epub 2020 Mar 16.PMID:32142286
Razai AS, Eckelman BP, Salvesen GS.
Selective inhibition of matrix metalloproteinase 10 (MMP10) with a single-domain antibody.
J Biol Chem. 2020 Jan 17. pii: jbc.RA119.011712. PMID:31953328
2019 Publications
Günther SD, Fritsch M, Seeger JM, Schiffmann LM, Snipas SJ, Coutelle M, Kufer TA, Higgins PG, Hornung V, Bernardini ML, Höning S, Krönke M, Salvesen GS, Kashkar H.
Cytosolic Gram-negative bacteria prevent apoptosis by inhibition of effector caspases through lipopolysaccharide.
Nat Microbiol. 2019 Dec 23. PMID: 31873204
Bibo-Verdugo B, Wang SC, Almaliti J, Ta AP, Jiang Z, Wong DA, Lietz CB, Suzuki B, El-Sakkary N, Hook VYH, Salvesen GS, Gerwick WH, Caffrey CR, O'Donoghue AJ.
The proteasome as a drug target in the metazoan pathogen, Schistosoma mansoni.
ACS Infect Dis. 2019 Jul 29. PMID:31355632
Poreba M, Groborz K, Vizovisek M, Maruggi M, Turk D, Turk B, Powis G, Drag M, Salvesen GS.
Fluorescent probes towards selective cathepsin B detection and visualization in cancer cells and patient samples.
Chem Sci. 2019 Jul 31;10(36):8461-8477. eCollection 2019 Sep 28. PMID:31803426
Burgener SS, Leborgne NGF, Snipas SJ, Salvesen GS, Bird PI, Benarafa C.
Cathepsin G Inhibition by Serpinb1 and Serpinb6 Prevents Programmed Necrosis in Neutrophils and Monocytes and Reduces GSDMD-Driven Inflammation.
Cell Rep. 2019 Jun 18;27(12):3646-3656.e5. PMID:31216481
Groborz K, Gonzalez Ramirez ML, Snipas SJ, Salvesen GS, Drąg M, Poręba M.
Exploring the prime site in caspases as a novel chemical strategy for understanding the mechanisms of cell death: a proof of concept study on necroptosis in cancer cells.
Cell Death Differ. 2019 Jun 17. PMID:31209360
Rashidi M, Simpson DS, Hempel A, Frank D, Petrie E, Vince A, Feltham R, Murphy J, Chatfield SM, Salvesen GS, Murphy JM, Wicks IP, Vince JE.
The Pyroptotic Cell Death Effector Gasdermin D Is Activated by Gout-Associated Uric Acid Crystals but Is Dispensable for Cell Death and IL-1β Release.
J Immunol. 2019 Aug 1;203(3):736-748. Epub 2019 Jun 17. PMID:31209100
Poreba M, Rut W, Groborz K, Snipas SJ, Salvesen GS, Drag M.
Potent and selective caspase-2 inhibitor prevents MDM-2 cleavage in reversine-treated colon cancer cells.
Cell Death Differ. 2019 Apr 11. PMID:30976094
Cogo F, Poreba M, Rut W, Groborz K, Smyth P, Johnston MC, Williams R, Longley DB,Burden RE, Salvesen GS, Drag M, Scott CJ.
Development of an advanced nanoformulation for the intracellular delivery of a caspase-3 selective activity-based probe.
Nanoscale. 2019 Jan 3;11(2):742-751. PMID:30566168
Günther SD, Fritsch M, Seeger JM, Schiffmann LM, Snipas SJ, Coutelle M, Kufer TA, Higgins PG, Hornung V, Bernardini ML, Höning S, Krönke M, Salvesen GS, Kashkar H.
Cytosolic Gram-negative bacteria prevent apoptosis by inhibition of effector caspases through lipopolysaccharide.
Nat Microbiol. 2019 Dec 23. PMID: 31873204
Bibo-Verdugo B, Wang SC, Almaliti J, Ta AP, Jiang Z, Wong DA, Lietz CB, Suzuki B, El-Sakkary N, Hook VYH, Salvesen GS, Gerwick WH, Caffrey CR, O'Donoghue AJ.
The proteasome as a drug target in the metazoan pathogen, Schistosoma mansoni.
ACS Infect Dis. 2019 Jul 29. PMID:31355632
Poreba M, Groborz K, Vizovisek M, Maruggi M, Turk D, Turk B, Powis G, Drag M, Salvesen GS.
Fluorescent probes towards selective cathepsin B detection and visualization in cancer cells and patient samples.
Chem Sci. 2019 Jul 31;10(36):8461-8477. eCollection 2019 Sep 28. PMID:31803426
Burgener SS, Leborgne NGF, Snipas SJ, Salvesen GS, Bird PI, Benarafa C.
Cathepsin G Inhibition by Serpinb1 and Serpinb6 Prevents Programmed Necrosis in Neutrophils and Monocytes and Reduces GSDMD-Driven Inflammation.
Cell Rep. 2019 Jun 18;27(12):3646-3656.e5. PMID:31216481
Groborz K, Gonzalez Ramirez ML, Snipas SJ, Salvesen GS, Drąg M, Poręba M.
Exploring the prime site in caspases as a novel chemical strategy for understanding the mechanisms of cell death: a proof of concept study on necroptosis in cancer cells.
Cell Death Differ. 2019 Jun 17. PMID:31209360
Rashidi M, Simpson DS, Hempel A, Frank D, Petrie E, Vince A, Feltham R, Murphy J, Chatfield SM, Salvesen GS, Murphy JM, Wicks IP, Vince JE.
The Pyroptotic Cell Death Effector Gasdermin D Is Activated by Gout-Associated Uric Acid Crystals but Is Dispensable for Cell Death and IL-1β Release.
J Immunol. 2019 Aug 1;203(3):736-748. Epub 2019 Jun 17. PMID:31209100
Poreba M, Rut W, Groborz K, Snipas SJ, Salvesen GS, Drag M.
Potent and selective caspase-2 inhibitor prevents MDM-2 cleavage in reversine-treated colon cancer cells.
Cell Death Differ. 2019 Apr 11. PMID:30976094
Cogo F, Poreba M, Rut W, Groborz K, Smyth P, Johnston MC, Williams R, Longley DB,Burden RE, Salvesen GS, Drag M, Scott CJ.
Development of an advanced nanoformulation for the intracellular delivery of a caspase-3 selective activity-based probe.
Nanoscale. 2019 Jan 3;11(2):742-751. PMID:30566168
2018 Publications
Kasperkiewicz P, Kołt S, Janiszewski T, Groborz K, Poręba M, Snipas SJ, Salvesen GS, Drąg M.
Determination of extended substrate specificity of the MALT1 as a strategy for the design of potent substrates and activity-based probes.
Sci Rep. 2018 Oct 30;8(1):15998. PMID:30375474
Vizovišek M, Vidmar R, Drag M, Fonović M, Salvesen GS, Turk B.
Protease Specificity: Towards In Vivo Imaging Applications and Biomarker Discovery.
Trends Biochem Sci. 2018 Oct;43(10):829-844. Epub 2018 Aug 7. Review. PMID:30097385
Rut W, Poręba M, Kasperkiewicz P, Snipas SJ, Drąg M.
Selective Substrates and Activity-Based Probes for Imaging of the Human Constitutive 20S Proteasome in Cells and Blood Samples.
J Med Chem. 2018 Jun 28;61(12):5222-5234. Epub 2018 Jun 9.PMID:29806773
Poreba M, Groborz K, Navarro M, Snipas SJ, Drag M, Salvesen GS.
Caspase selective reagents for diagnosing apoptotic mechanisms.
Cell Death Differ. 2019 Feb;26(2):229-244. Epub 2018 May 10. PMID:29748600
Poreba M, Rut W, Vizovisek M, Groborz K, Kasperkiewicz P, Finlay D, Vuori K, Turk D, Turk B, Salvesen GS, Drag M.
Selective imaging of cathepsin L in breast cancer by fluorescent activity-based probes.
Chem Sci. 2018 Jan 16;9(8):2113-2129. eCollection 2018 Feb 28. PMID:29719685
Ramirez MLG, Poreba M, Snipas SJ, Groborz K, Drag M, Salvesen GS.
Extensive peptide and natural protein substrate screens reveal that mouse caspase-11 has much narrower substrate specificity than caspase-1.
J Biol Chem. 2018 May 4;293(18):7058-7067. Epub 2018 Feb 6. PMID:29414788
Ramirez MLG, Salvesen GS.
A primer on caspase mechanisms.
Semin Cell Dev Biol. 2018 Oct;82:79-85. Epub 2018 Jan 12. Review. PMID: 29329946
Kasperkiewicz P, Kołt S, Janiszewski T, Groborz K, Poręba M, Snipas SJ, Salvesen GS, Drąg M.
Determination of extended substrate specificity of the MALT1 as a strategy for the design of potent substrates and activity-based probes.
Sci Rep. 2018 Oct 30;8(1):15998. PMID:30375474
Vizovišek M, Vidmar R, Drag M, Fonović M, Salvesen GS, Turk B.
Protease Specificity: Towards In Vivo Imaging Applications and Biomarker Discovery.
Trends Biochem Sci. 2018 Oct;43(10):829-844. Epub 2018 Aug 7. Review. PMID:30097385
Rut W, Poręba M, Kasperkiewicz P, Snipas SJ, Drąg M.
Selective Substrates and Activity-Based Probes for Imaging of the Human Constitutive 20S Proteasome in Cells and Blood Samples.
J Med Chem. 2018 Jun 28;61(12):5222-5234. Epub 2018 Jun 9.PMID:29806773
Poreba M, Groborz K, Navarro M, Snipas SJ, Drag M, Salvesen GS.
Caspase selective reagents for diagnosing apoptotic mechanisms.
Cell Death Differ. 2019 Feb;26(2):229-244. Epub 2018 May 10. PMID:29748600
Poreba M, Rut W, Vizovisek M, Groborz K, Kasperkiewicz P, Finlay D, Vuori K, Turk D, Turk B, Salvesen GS, Drag M.
Selective imaging of cathepsin L in breast cancer by fluorescent activity-based probes.
Chem Sci. 2018 Jan 16;9(8):2113-2129. eCollection 2018 Feb 28. PMID:29719685
Ramirez MLG, Poreba M, Snipas SJ, Groborz K, Drag M, Salvesen GS.
Extensive peptide and natural protein substrate screens reveal that mouse caspase-11 has much narrower substrate specificity than caspase-1.
J Biol Chem. 2018 May 4;293(18):7058-7067. Epub 2018 Feb 6. PMID:29414788
Ramirez MLG, Salvesen GS.
A primer on caspase mechanisms.
Semin Cell Dev Biol. 2018 Oct;82:79-85. Epub 2018 Jan 12. Review. PMID: 29329946
2017 Publications
Poreba M, Salvesen GS, Drag M.
Synthesis of a HyCoSuL peptide substrate library to dissect protease substrate specificity.
Nat Protoc. 2017 Oct;12(10):2189-2214. Epub 2017 Sep 21. PubMed PMID: 28933778.
Kasperkiewicz P, Altman Y, D'Angelo M, Salvesen GS, Drag M.
Toolbox of Fluorescent Probes for Parallel Imaging Reveals Uneven Location of Serine Proteases in Neutrophils.
J Am Chem Soc. 2017 Jul 26;139(29):10115-10125. Epub 2017 Jul 18. PubMed PMID: 28672107.
Poreba M, Salvesen G.
Return of the Ice Age: Caspases Safeguard against Inflammatory Cell Death.
Cell Chem Biol. 2017 May 18;24(5):550-552. PubMed PMID: 28525771.
Poreba M, Szalek A, Rut W, Kasperkiewicz P, Rutkowska-Wlodarczyk I, Snipas SJ, Itoh Y, Turk D, Turk B, Overall CM, Kaczmarek L, Salvesen GS, Drag M.
Highly sensitive and adaptable fluorescence-quenched pair discloses the substrate specificity profiles in diverse protease families.
Sci Rep. 2017 Feb 23;7:43135. PubMed PMID: 28230157
Lee P, Zhu Z, Hachmann J, Nojima T, Kitamura D, Salvesen G, Rickert RC.
Differing Requirements for MALT1 Function in Peripheral B Cell Survival and Differentiation.
J Immunol. 2017 Feb 1;198(3):1066-1080. Epub 2016 Dec 28. PubMed PMID: 28031341
Poreba M, Salvesen GS, Drag M.
Synthesis of a HyCoSuL peptide substrate library to dissect protease substrate specificity.
Nat Protoc. 2017 Oct;12(10):2189-2214. Epub 2017 Sep 21. PubMed PMID: 28933778.
Kasperkiewicz P, Altman Y, D'Angelo M, Salvesen GS, Drag M.
Toolbox of Fluorescent Probes for Parallel Imaging Reveals Uneven Location of Serine Proteases in Neutrophils.
J Am Chem Soc. 2017 Jul 26;139(29):10115-10125. Epub 2017 Jul 18. PubMed PMID: 28672107.
Poreba M, Salvesen G.
Return of the Ice Age: Caspases Safeguard against Inflammatory Cell Death.
Cell Chem Biol. 2017 May 18;24(5):550-552. PubMed PMID: 28525771.
Poreba M, Szalek A, Rut W, Kasperkiewicz P, Rutkowska-Wlodarczyk I, Snipas SJ, Itoh Y, Turk D, Turk B, Overall CM, Kaczmarek L, Salvesen GS, Drag M.
Highly sensitive and adaptable fluorescence-quenched pair discloses the substrate specificity profiles in diverse protease families.
Sci Rep. 2017 Feb 23;7:43135. PubMed PMID: 28230157
Lee P, Zhu Z, Hachmann J, Nojima T, Kitamura D, Salvesen G, Rickert RC.
Differing Requirements for MALT1 Function in Peripheral B Cell Survival and Differentiation.
J Immunol. 2017 Feb 1;198(3):1066-1080. Epub 2016 Dec 28. PubMed PMID: 28031341
2016 Publications
Fasci D, Anania V, Lill J, Salvesen G.
Response to Comment on "SUMO deconjugation is required for arsenic-triggered ubiquitylation of PML".
Sci Signal. 2016 Aug 9;9(440):tc2. PubMed PMID: 27507652.
Poreba M, Solberg R, Rut W, Lunde NN, Kasperkiewicz P, Snipas SJ, Mihelic M, Turk D, Turk B, Salvesen GS, Drag M.
Counter Selection Substrate Library Strategy for Developing Specific Protease Substrates and Probes.
Cell Chem Biol. 2016 Aug 18;23(8):1023-35. Epub 2016 Jul 28. PubMed PMID: 27478158.
Brumatti G, Ma C, Lalaoui N, Nguyen NY, Navarro M, Tanzer MC, Richmond J, Ghisi M, Salmon JM, Silke N, Pomilio G, Glaser SP, de Valle E, Gugasyan R, Gurthridge MA, Condon SM, Johnstone RW, Lock R, Salvesen G, Wei A, Vaux DL, Ekert PG, Silke J.
The caspase-8 inhibitor emricasan combines with the SMAC mimetic birinapant to induce necroptosis and treat acute myeloid leukemia.
Sci Transl Med. 2016 May 18;8(339):339ra69. Erratum in: Sci Transl Med. 2017 May 31;9(392):. PubMed PMID: 27194727.
Oroz-Parra I, Navarro M, Cervantes-Luevano KE, Álvarez-Delgado C, Salvesen G, Sanchez-Campos LN, Licea-Navarro AF.
Apoptosis Activation in Human Lung Cancer Cell Lines by a Novel Synthetic Peptide Derived from Conus californicus Venom.
Toxins (Basel). 2016 Feb 5;8(2):38. PubMed PMID: 26861394; PubMed Central PMCID: PMC4773791.
Park G, Tan J, Garcia G, Kang Y, Salvesen G, Zhang Z.
Regulation of Histone Acetylation by Autophagy in Parkinson Disease.
J Biol Chem. 2016 Feb 12;291(7):3531-40. Epub 2015 Dec 23. PubMed PMID: 26699403; PubMed Central PMCID: PMC4751393.
Salvesen GS, Hempel A, Coll NS.
Protease signaling in animal and plant-regulated cell death.
FEBS J. 2016 Jul;283(14):2577-98. Epub 2015 Dec 31. Review. PubMed PMID: 26648190; PubMed Central PMCID: PMC5606204.
Metkar SS, Pardo J, Anderluh G, Salvesen G, Trapani JA, Simon MM.
In memoriam: Prof Christopher J Froelich (1951-2015).
Cell Death Differ. 2016 Jan;23(1):3-4. PubMed PMID: 26639556; PubMed Central PMCID: PMC4815969.
Hachmann J, Salvesen GS.
The Paracaspase MALT1.
Biochimie. 2016 Mar;122:324-38. Epub 2015 Sep 16. Review. PubMed PMID: 26386283; PubMed Central PMCID: PMC4747852.
Fasci D, Anania V, Lill J, Salvesen G.
Response to Comment on "SUMO deconjugation is required for arsenic-triggered ubiquitylation of PML".
Sci Signal. 2016 Aug 9;9(440):tc2. PubMed PMID: 27507652.
Poreba M, Solberg R, Rut W, Lunde NN, Kasperkiewicz P, Snipas SJ, Mihelic M, Turk D, Turk B, Salvesen GS, Drag M.
Counter Selection Substrate Library Strategy for Developing Specific Protease Substrates and Probes.
Cell Chem Biol. 2016 Aug 18;23(8):1023-35. Epub 2016 Jul 28. PubMed PMID: 27478158.
Brumatti G, Ma C, Lalaoui N, Nguyen NY, Navarro M, Tanzer MC, Richmond J, Ghisi M, Salmon JM, Silke N, Pomilio G, Glaser SP, de Valle E, Gugasyan R, Gurthridge MA, Condon SM, Johnstone RW, Lock R, Salvesen G, Wei A, Vaux DL, Ekert PG, Silke J.
The caspase-8 inhibitor emricasan combines with the SMAC mimetic birinapant to induce necroptosis and treat acute myeloid leukemia.
Sci Transl Med. 2016 May 18;8(339):339ra69. Erratum in: Sci Transl Med. 2017 May 31;9(392):. PubMed PMID: 27194727.
Oroz-Parra I, Navarro M, Cervantes-Luevano KE, Álvarez-Delgado C, Salvesen G, Sanchez-Campos LN, Licea-Navarro AF.
Apoptosis Activation in Human Lung Cancer Cell Lines by a Novel Synthetic Peptide Derived from Conus californicus Venom.
Toxins (Basel). 2016 Feb 5;8(2):38. PubMed PMID: 26861394; PubMed Central PMCID: PMC4773791.
Park G, Tan J, Garcia G, Kang Y, Salvesen G, Zhang Z.
Regulation of Histone Acetylation by Autophagy in Parkinson Disease.
J Biol Chem. 2016 Feb 12;291(7):3531-40. Epub 2015 Dec 23. PubMed PMID: 26699403; PubMed Central PMCID: PMC4751393.
Salvesen GS, Hempel A, Coll NS.
Protease signaling in animal and plant-regulated cell death.
FEBS J. 2016 Jul;283(14):2577-98. Epub 2015 Dec 31. Review. PubMed PMID: 26648190; PubMed Central PMCID: PMC5606204.
Metkar SS, Pardo J, Anderluh G, Salvesen G, Trapani JA, Simon MM.
In memoriam: Prof Christopher J Froelich (1951-2015).
Cell Death Differ. 2016 Jan;23(1):3-4. PubMed PMID: 26639556; PubMed Central PMCID: PMC4815969.
Hachmann J, Salvesen GS.
The Paracaspase MALT1.
Biochimie. 2016 Mar;122:324-38. Epub 2015 Sep 16. Review. PubMed PMID: 26386283; PubMed Central PMCID: PMC4747852.
2015 Publications
Hachmann J, Edgington-Mitchell LE, Poreba M, Sanman LE, Drag. M. Bogyo M, Salvesen GS.
Probes to monitor activity of the paracaspase MALT1.
Chem Biol. 2015 Jan 22;22(1):139-47. Epub 2014 Dec 31. PMID:25556944
Poreba M, Szalek A, Kasperkiewicz P, Rut W, Salvesen GS, Drag M.
Small Molecule Active Site Directed Tools for Studying Human Caspases.
Chem Rev. 2015 Nov 25;115(22):12546-629. Epub 2015 Nov 9. Review. PubMed PMID: 26551511; PubMed Central PMCID: PMC5610424.
Rajković J, Poreba M, Caglič D, Vidmar R, Wilk A, Borowik A, Salvesen G, Turk V, Drag M, Turk B.
Biochemical Characterization and Substrate Specificity of Autophagin-2 from the Parasite Trypanosoma cruzi.
J Biol Chem. 2015 Nov 20;290(47):28231-44. Epub 2015 Oct 7. PMID:26446788
Kayagaki N, Stowe IB, Lee BL, O'Rourke K, Anderson K, Warming S, Cuellar T, Haley B, Roose-Girma M, Phung QT, Liu PS, Lill JR, Li H, Wu J, Kummerfeld S, Zhang J, Lee WP, Snipas SJ, Salvesen GS, Morris LX, Fitzgerald L, Zhang Y, Bertram EM, Goodnow CC, Dixit VM.
Caspase-11 cleaves gasdermin D for non-canonical inflammasome signalling.
Nature. 2015 Oct 29;526(7575):666-71. Epub 2015 Sep 16. PubMed PMID: 26375259.
Kasperkiewicz P, Poreba M, Snipas SJ, Lin SJ, Kirchhofer D, Salvesen GS, Drag M.
Design of a Selective Substrate and Activity Based Probe for Human Neutrophil Serine Protease 4.
PLoS One. 2015 Jul 14;10(7):e0132818. eCollection 2015. PubMed PMID: 26172376; PubMed Central PMCID: PMC4501687.
Fasci D, Anania VG, Lill JR, Salvesen GS.
SUMO deconjugation is required for arsenic-triggered ubiquitylation of PML.
Sci Signal. 2015 Jun 9;8(380):ra56. PubMed PMID: 26060329; PubMed Central PMCID: PMC4603552.
Hachmann J, Edgington-Mitchell LE, Poreba M, Sanman LE, Drag. M. Bogyo M, Salvesen GS.
Probes to monitor activity of the paracaspase MALT1.
Chem Biol. 2015 Jan 22;22(1):139-47. Epub 2014 Dec 31. PMID:25556944
Poreba M, Szalek A, Kasperkiewicz P, Rut W, Salvesen GS, Drag M.
Small Molecule Active Site Directed Tools for Studying Human Caspases.
Chem Rev. 2015 Nov 25;115(22):12546-629. Epub 2015 Nov 9. Review. PubMed PMID: 26551511; PubMed Central PMCID: PMC5610424.
Rajković J, Poreba M, Caglič D, Vidmar R, Wilk A, Borowik A, Salvesen G, Turk V, Drag M, Turk B.
Biochemical Characterization and Substrate Specificity of Autophagin-2 from the Parasite Trypanosoma cruzi.
J Biol Chem. 2015 Nov 20;290(47):28231-44. Epub 2015 Oct 7. PMID:26446788
Kayagaki N, Stowe IB, Lee BL, O'Rourke K, Anderson K, Warming S, Cuellar T, Haley B, Roose-Girma M, Phung QT, Liu PS, Lill JR, Li H, Wu J, Kummerfeld S, Zhang J, Lee WP, Snipas SJ, Salvesen GS, Morris LX, Fitzgerald L, Zhang Y, Bertram EM, Goodnow CC, Dixit VM.
Caspase-11 cleaves gasdermin D for non-canonical inflammasome signalling.
Nature. 2015 Oct 29;526(7575):666-71. Epub 2015 Sep 16. PubMed PMID: 26375259.
Kasperkiewicz P, Poreba M, Snipas SJ, Lin SJ, Kirchhofer D, Salvesen GS, Drag M.
Design of a Selective Substrate and Activity Based Probe for Human Neutrophil Serine Protease 4.
PLoS One. 2015 Jul 14;10(7):e0132818. eCollection 2015. PubMed PMID: 26172376; PubMed Central PMCID: PMC4501687.
Fasci D, Anania VG, Lill JR, Salvesen GS.
SUMO deconjugation is required for arsenic-triggered ubiquitylation of PML.
Sci Signal. 2015 Jun 9;8(380):ra56. PubMed PMID: 26060329; PubMed Central PMCID: PMC4603552.
2014 Publications
Goulas T, Cuppari A, Garcia-Castellanos R, Snipas S, Glockshuber R, Arolas JL, Gomis-Rüth FX.
The pCri System: a vector collection for recombinant protein expression and purification.
PLoS One. 2014 Nov 11;9(11):e112643. eCollection 2014. PMID:25386923
Kumar S, van Raam BJ, Salvesen GS, Cieplak P.
Caspase cleavage sites in the human proteome: CaspDB, a database of predicted substrates.
PLoS One. 2014 Oct 17;9(10):e110539. eCollection 2014.PMID:25330111
Mace PD, Riedl, SJ, Salvesen GS.
Caspase enzymology and activation mechanisms.
Methods Enzymol. 2014;544:161-78. PMID:24974290
Ashkenazi A, Salvesen G.
Regulated cell death: signaling and mechanisms.
Annu Rev Cell Dev Biol. 2014;30:337-56. Epub 2014 Aug 13. Review. PMID:25150011
Salvesen GS, Walsh CM.
Functions of caspase 8: the identified and the mysterious.
Semin Immunol. 2014 Jun;26(3):246-52. Epub 2014 May 21. Review. PMID:24856110
Poreba M, Kasperkiewicz P, Snipas SJ, Fasci D, Salvesen GS, Drag M.
Unnatural amino acids increase sensitivity and provide for the design of highly selective caspase substrates.
Cell Death Differ. 2014 May 16. PMID: 24832467
Oberst A, Pop C, Tremblay AG, Blais V, Denault JB, Salvesen GS, Green DR.
Inducible dimerization and inducible cleavage reveal a requirement for both processes in caspase-8 activation.
J Biol Chem. 2014 Mar 7;289(10):6838. PMID:24787012
Pustelny K, Zdzalik M, Stach N, Stec-Niemczyk J, Cichon P, Czarna A, Popowicz G, Mak P, Drag M, Salvesen GS, Wladyka B, Potempa J, Dubin A, Dubin G.
Staphylococcal SplB serine protease utilizes a novel molecular mechanism of activation.
J Biol Chem. 2014 Apr 8. PMID:24713703
Byzia A, Haeggström JZ, Salvesen GS, Drag M.
A remarkable activity of human leukotriene A4 hydrolase (LTA4H) toward unnatural amino acids.
Amino Acids. 2014 May;46(5):1313-20. Epub 2014 Feb 27. PMID:24573245
Kasperkiewicz P, Poreba M, Snipas SJ, Parker H, Winterbourn CC, Salvesen GS, Drag M.
Design of ultrasensitive probes for human neutrophil elastase through hybrid combinatorial substrate library profiling.
Proc Natl Acad Sci U S A. 2014 Feb 18;111(7):2518-23. Epub 2014 Feb 3. PMID: 24550277
Salvesen GS.
Dying from within: granzyme B converts entosis to emperitosis.
Cell Death Differ. 2014 Jan;21(1):3-4. PMID:24317271
Goulas T, Cuppari A, Garcia-Castellanos R, Snipas S, Glockshuber R, Arolas JL, Gomis-Rüth FX.
The pCri System: a vector collection for recombinant protein expression and purification.
PLoS One. 2014 Nov 11;9(11):e112643. eCollection 2014. PMID:25386923
Kumar S, van Raam BJ, Salvesen GS, Cieplak P.
Caspase cleavage sites in the human proteome: CaspDB, a database of predicted substrates.
PLoS One. 2014 Oct 17;9(10):e110539. eCollection 2014.PMID:25330111
Mace PD, Riedl, SJ, Salvesen GS.
Caspase enzymology and activation mechanisms.
Methods Enzymol. 2014;544:161-78. PMID:24974290
Ashkenazi A, Salvesen G.
Regulated cell death: signaling and mechanisms.
Annu Rev Cell Dev Biol. 2014;30:337-56. Epub 2014 Aug 13. Review. PMID:25150011
Salvesen GS, Walsh CM.
Functions of caspase 8: the identified and the mysterious.
Semin Immunol. 2014 Jun;26(3):246-52. Epub 2014 May 21. Review. PMID:24856110
Poreba M, Kasperkiewicz P, Snipas SJ, Fasci D, Salvesen GS, Drag M.
Unnatural amino acids increase sensitivity and provide for the design of highly selective caspase substrates.
Cell Death Differ. 2014 May 16. PMID: 24832467
Oberst A, Pop C, Tremblay AG, Blais V, Denault JB, Salvesen GS, Green DR.
Inducible dimerization and inducible cleavage reveal a requirement for both processes in caspase-8 activation.
J Biol Chem. 2014 Mar 7;289(10):6838. PMID:24787012
Pustelny K, Zdzalik M, Stach N, Stec-Niemczyk J, Cichon P, Czarna A, Popowicz G, Mak P, Drag M, Salvesen GS, Wladyka B, Potempa J, Dubin A, Dubin G.
Staphylococcal SplB serine protease utilizes a novel molecular mechanism of activation.
J Biol Chem. 2014 Apr 8. PMID:24713703
Byzia A, Haeggström JZ, Salvesen GS, Drag M.
A remarkable activity of human leukotriene A4 hydrolase (LTA4H) toward unnatural amino acids.
Amino Acids. 2014 May;46(5):1313-20. Epub 2014 Feb 27. PMID:24573245
Kasperkiewicz P, Poreba M, Snipas SJ, Parker H, Winterbourn CC, Salvesen GS, Drag M.
Design of ultrasensitive probes for human neutrophil elastase through hybrid combinatorial substrate library profiling.
Proc Natl Acad Sci U S A. 2014 Feb 18;111(7):2518-23. Epub 2014 Feb 3. PMID: 24550277
Salvesen GS.
Dying from within: granzyme B converts entosis to emperitosis.
Cell Death Differ. 2014 Jan;21(1):3-4. PMID:24317271
2013 Publications
Poreba M, Strózyk A, Salvesen GS, Drag M.
Caspase substrates and inhibitors.
Cold Spring Harb Perspect Biol. 2013 Aug 1;5(8):a008680. Review. PMID:23788633
Vamos M, Welsh K, Finlay D, Lee PS, Mace PD, Snipas SJ, Gonzalez ML, Ganji SR, Ardecky RJ, Riedl SJ, Salvesen GS, Vuori K, Reed JC, Cosford ND.
Expedient synthesis of highly potent antagonists of inhibitor of apoptosis proteins (IAPs) with unique selectivityfor ML-IAP.
ACS Chem Biol. 2013 Apr 19;8(4):725-32. Epub 2013 Feb 5. PMID: 23323685
Poreba M, Strózyk A, Salvesen GS, Drag M.
Caspase substrates and inhibitors.
Cold Spring Harb Perspect Biol. 2013 Aug 1;5(8):a008680. Review. PMID:23788633
Vamos M, Welsh K, Finlay D, Lee PS, Mace PD, Snipas SJ, Gonzalez ML, Ganji SR, Ardecky RJ, Riedl SJ, Salvesen GS, Vuori K, Reed JC, Cosford ND.
Expedient synthesis of highly potent antagonists of inhibitor of apoptosis proteins (IAPs) with unique selectivityfor ML-IAP.
ACS Chem Biol. 2013 Apr 19;8(4):725-32. Epub 2013 Feb 5. PMID: 23323685
2012 Publications
Aleshin AE, Drag M, Gombosuren N, Wei G, Mikolajczyk J, Satterthwait AC, Strongin AY, Liddington RC, Salvesen GS.
Activity, Specificity, and Probe Design for the Smallpox Virus Protease K7L.
J Biol Chem. 2012 Nov 16;287(47):39470-9.PMID:23012361
Salvesen GS, Bogyo M.
Highlight: the universe of proteolytic networks and mechanisms.
Biol Chem. 2012 Sep;393(9):841. PMID:22944685
van Raam BJ, Ehrnhoefer DE, Hayden MR, Salvesen GS.
Intrinsic cleavage of receptor-interacting protein kinase-1 by caspase-6.
Cell Death Differ. 2012 Aug 3. PMID:22858542
Conus S, Pop C, Snipas SJ, Salvesen GS, Simon HU.
Cathepsin D primes caspase-8 activation by multiple intra-chain proteolysis.
J Biol Chem. 2012 Jun 15;287(25):21142-51. PMID:22528489
Sivaraman KK, Oellig CA, Huynh K, Atkinson SC, Poreba M, Perugini MA, Trenholme KR, Gardiner DL, Salvesen G, Drag M, Dalton JP, Whisstock JC, McGowan S.
X-ray crystal structure and specificity of the Plasmodium falciparum malaria aminopeptidase PfM18AAP.
J Mol Biol. 2012 Sep 28;422(4):495-507. Epub 2012 Jun 16. PMID:22709581
Rickert RC, Salvesen GS, Ware CF.
Mousing around with caspases and IAPs.
Biochem J. 2012 Apr 15;443(2):e1-2. PMID:22452818
Edgington LE, van Raam BJ, Verdoes M, Wierschem C, Salvesen GS, Bogyo M.
An optimized activity-based probe for the study of caspase-6 activation.
Chem Biol. 2012 Mar 23;19(3):340-52. PMID:22444589
Bender CE, Fitzgerald P, Tait SW, Llambi F, McStay GP, Tupper DO, Pellettieri J, Sánchez Alvarado A, Salvesen GS, Green DR.
Mitochondrial pathway of apoptosis is ancestral in metazoans.
Proc Natl Acad Sci U S A. 2012 Mar 27;109(13):4904-9. PMID:22416118
Poreba M, McGowan S, Skinner-Adams TS, Trenholme KR, Gardiner DL, Whisstock JC, To J, Salvesen GS, Dalton JP, Drag M.
Fingerprinting the substrate specificity of M1 and M17 aminopeptidases of human malaria, Plasmodium falciparum.
PLoS One. 2012;7(2):e31938. PMID:22359643
Hachmann J, Snipas SJ, van Raam BJ, Cancino EM, Houlihan EJ, Poreba M, Kasperkiewicz P, Drag M, Salvesen GS.
Mechanism and specificity of the human paracaspase MALT1.
Biochem J. 2012 Apr 1;443(1):287-95. PMID:22309193
Dobrotă C, Fasci D, Hădade ND, Roiban GD, Pop C, Meier VM, Dumitru I, Matache M, Salvesen GS, Funeriu DP.
Glycine fluoromethylketones as SENP-specific activity based probes.
Chembiochem. 2012 Jan 2;13(1):80-4. PMID:22134988
Poreba M, Gajda A, Picha J, Jiracek J, Marschner A, Klein CD, Salvesen GS, Drag M.
S1 pocket fingerprints of human and bacterial methionine aminopeptidases determined using fluorogenic libraries of substrates and phosphorus based inhibitors.
Biochimie. 2012 Mar;94(3):704-10. PMID:22085501
Aleshin AE, Drag M, Gombosuren N, Wei G, Mikolajczyk J, Satterthwait AC, Strongin AY, Liddington RC, Salvesen GS.
Activity, Specificity, and Probe Design for the Smallpox Virus Protease K7L.
J Biol Chem. 2012 Nov 16;287(47):39470-9.PMID:23012361
Salvesen GS, Bogyo M.
Highlight: the universe of proteolytic networks and mechanisms.
Biol Chem. 2012 Sep;393(9):841. PMID:22944685
van Raam BJ, Ehrnhoefer DE, Hayden MR, Salvesen GS.
Intrinsic cleavage of receptor-interacting protein kinase-1 by caspase-6.
Cell Death Differ. 2012 Aug 3. PMID:22858542
Conus S, Pop C, Snipas SJ, Salvesen GS, Simon HU.
Cathepsin D primes caspase-8 activation by multiple intra-chain proteolysis.
J Biol Chem. 2012 Jun 15;287(25):21142-51. PMID:22528489
Sivaraman KK, Oellig CA, Huynh K, Atkinson SC, Poreba M, Perugini MA, Trenholme KR, Gardiner DL, Salvesen G, Drag M, Dalton JP, Whisstock JC, McGowan S.
X-ray crystal structure and specificity of the Plasmodium falciparum malaria aminopeptidase PfM18AAP.
J Mol Biol. 2012 Sep 28;422(4):495-507. Epub 2012 Jun 16. PMID:22709581
Rickert RC, Salvesen GS, Ware CF.
Mousing around with caspases and IAPs.
Biochem J. 2012 Apr 15;443(2):e1-2. PMID:22452818
Edgington LE, van Raam BJ, Verdoes M, Wierschem C, Salvesen GS, Bogyo M.
An optimized activity-based probe for the study of caspase-6 activation.
Chem Biol. 2012 Mar 23;19(3):340-52. PMID:22444589
Bender CE, Fitzgerald P, Tait SW, Llambi F, McStay GP, Tupper DO, Pellettieri J, Sánchez Alvarado A, Salvesen GS, Green DR.
Mitochondrial pathway of apoptosis is ancestral in metazoans.
Proc Natl Acad Sci U S A. 2012 Mar 27;109(13):4904-9. PMID:22416118
Poreba M, McGowan S, Skinner-Adams TS, Trenholme KR, Gardiner DL, Whisstock JC, To J, Salvesen GS, Dalton JP, Drag M.
Fingerprinting the substrate specificity of M1 and M17 aminopeptidases of human malaria, Plasmodium falciparum.
PLoS One. 2012;7(2):e31938. PMID:22359643
Hachmann J, Snipas SJ, van Raam BJ, Cancino EM, Houlihan EJ, Poreba M, Kasperkiewicz P, Drag M, Salvesen GS.
Mechanism and specificity of the human paracaspase MALT1.
Biochem J. 2012 Apr 1;443(1):287-95. PMID:22309193
Dobrotă C, Fasci D, Hădade ND, Roiban GD, Pop C, Meier VM, Dumitru I, Matache M, Salvesen GS, Funeriu DP.
Glycine fluoromethylketones as SENP-specific activity based probes.
Chembiochem. 2012 Jan 2;13(1):80-4. PMID:22134988
Poreba M, Gajda A, Picha J, Jiracek J, Marschner A, Klein CD, Salvesen GS, Drag M.
S1 pocket fingerprints of human and bacterial methionine aminopeptidases determined using fluorogenic libraries of substrates and phosphorus based inhibitors.
Biochimie. 2012 Mar;94(3):704-10. PMID:22085501
2011 Publications
Salvesen GS, Ashkenazi A.
Snapshot: caspases.
Cell. 2011 Oct 14;147(2):476-476.e1. PMID:22000022
Green DR, Oberst A, Dillon CP, Weinlich R, Salvesen GS.
RIPK-dependent necrosis and its regulation by caspases: a mystery in five acts.
Mol Cell. 2011 Oct 7;44(1):9-16.PMID:21981915
Lu JV, Weist BM, van Raam BJ, Marro BS, Nguyen LV, Srinivas P, Bell BD, Luhrs KA, Lane TE, Salvesen GS, Walsh CM.
Complementary roles of Fas-associated death domain (FADD) and receptor interacting protein kinase-3 (RIPK3) in T-cell homeostasis and antiviral immunity.
Proc Natl Acad Sci U S A. 2011 Sep 13;108(37):15312-7. Epub 2011 Aug 29. PMID:21876153
van Raam BJ, Salvesen GS.
Proliferative versus apoptotic functions of caspase-8 Hetero or homo: The caspase-8 dimer controls cell fate.
Biochim Biophys Acta. 2011 Jun 16. PMID:21704196
Albrow VE, Ponder EL, Fasci D, Békés M, Deu E, Salvesen GS, Bogyo M.
Development of small molecule inhibitors and probes of human SUMO deconjugating proteases.
Chem Biol. 2011 Jun 24;18(6):722-32. PMID:21700208
Ponder EL, Albrow VE, Leader BA, Békés M, Mikolajczyk J, Fonović UP, Shen A, Drag M, Xiao J, Deu E, Campbell AJ, Powers JC, Salvesen GS, Bogyo M.
Functional characterization of a SUMO deconjugating protease of Plasmodium falciparum using newly identified small molecule inhibitors.
Chem Biol. 2011 Jun 24;18(6):711-21. PMID:21700207
Akpan N, Serrano-Saiz E, Zacharia BE, Otten ML, Ducruet AF, Snipas SJ, Liu W, Velloza J, Cohen G, Sosunov SA, Frey WH 2nd, Salvesen GS, Connolly ES Jr, Troy CM.
Intranasal delivery of caspase-9 inhibitor reduces caspase-6-dependent axon/neuron loss and improves neurological function after stroke.
J Neurosci. 2011 Jun 15;31(24):8894-904. PMID:21677173
Timmer JC, Salvesen GS.
N-terminomics: a high-content screen for protease substrates and their cleavage sites.
Methods Mol Biol. 2011;753:243-55.PMID:21604127
Oberst A, Dillon CP, Weinlich R, McCormick LL, Fitzgerald P, Pop C, Hakem R, Salvesen GS, Green DR.
Catalytic activity of the caspase-8-FLIP(L) complex inhibits RIPK3-dependent necrosis.
Nature. 2011 Mar 17;471(7338):363-7. Epub 2011 Mar 2.PMID:21368763
Zervoudi E, Papakyriakou A, Georgiadou D, Evnouchidou I, Gajda A, Poreba M, Salvesen GS, Drag M, Hattori A, Swevers L, Vourloumis D, Stratikos E.
Probing the S1 specificity pocket of the aminopeptidases that generate antigenic peptides.
Biochem J. 2011 Apr 15;435(2):411-20.PMID:21314638
Békés M, Prudden J, Srikumar T, Raught B, Boddy MN, Salvesen GS.
The dynamics and mechanism of sumo chain deconjugation by SUMO-specific proteases.
J Biol Chem. 2011 Jan 20.PMID: 21247896
Leverrier S, Salvesen GS, Walsh CM.
Enzymatically active single chain caspase-8 maintains T-cell survival during clonal expansion.
Cell Death Differ. 2011 Jan;18(1):90-8. Epub 2010 Jun 4. PMID:20523353
Petroski MD, Salvesen GS, Wolf DA.
Urm1 couples sulfur transfer to ubiquitin-like protein function in oxidative stress.
Proc Natl Acad Sci U S A. 2011 Jan 18.PMID: 21245332
Pop C, Oberst A, Drag M, van Raam BJ, Riedl SJ, Green DR, Salvesen GS.
FLIPL induces caspase 8 activity in the absence of interdomain caspase 8 cleavage and alters substrate specificity.
Biochem J. 2011 Jan 14;433(3):447-57. PMID: 21235526
Salvesen GS, Ashkenazi A.
Snapshot: caspases.
Cell. 2011 Oct 14;147(2):476-476.e1. PMID:22000022
Green DR, Oberst A, Dillon CP, Weinlich R, Salvesen GS.
RIPK-dependent necrosis and its regulation by caspases: a mystery in five acts.
Mol Cell. 2011 Oct 7;44(1):9-16.PMID:21981915
Lu JV, Weist BM, van Raam BJ, Marro BS, Nguyen LV, Srinivas P, Bell BD, Luhrs KA, Lane TE, Salvesen GS, Walsh CM.
Complementary roles of Fas-associated death domain (FADD) and receptor interacting protein kinase-3 (RIPK3) in T-cell homeostasis and antiviral immunity.
Proc Natl Acad Sci U S A. 2011 Sep 13;108(37):15312-7. Epub 2011 Aug 29. PMID:21876153
van Raam BJ, Salvesen GS.
Proliferative versus apoptotic functions of caspase-8 Hetero or homo: The caspase-8 dimer controls cell fate.
Biochim Biophys Acta. 2011 Jun 16. PMID:21704196
Albrow VE, Ponder EL, Fasci D, Békés M, Deu E, Salvesen GS, Bogyo M.
Development of small molecule inhibitors and probes of human SUMO deconjugating proteases.
Chem Biol. 2011 Jun 24;18(6):722-32. PMID:21700208
Ponder EL, Albrow VE, Leader BA, Békés M, Mikolajczyk J, Fonović UP, Shen A, Drag M, Xiao J, Deu E, Campbell AJ, Powers JC, Salvesen GS, Bogyo M.
Functional characterization of a SUMO deconjugating protease of Plasmodium falciparum using newly identified small molecule inhibitors.
Chem Biol. 2011 Jun 24;18(6):711-21. PMID:21700207
Akpan N, Serrano-Saiz E, Zacharia BE, Otten ML, Ducruet AF, Snipas SJ, Liu W, Velloza J, Cohen G, Sosunov SA, Frey WH 2nd, Salvesen GS, Connolly ES Jr, Troy CM.
Intranasal delivery of caspase-9 inhibitor reduces caspase-6-dependent axon/neuron loss and improves neurological function after stroke.
J Neurosci. 2011 Jun 15;31(24):8894-904. PMID:21677173
Timmer JC, Salvesen GS.
N-terminomics: a high-content screen for protease substrates and their cleavage sites.
Methods Mol Biol. 2011;753:243-55.PMID:21604127
Oberst A, Dillon CP, Weinlich R, McCormick LL, Fitzgerald P, Pop C, Hakem R, Salvesen GS, Green DR.
Catalytic activity of the caspase-8-FLIP(L) complex inhibits RIPK3-dependent necrosis.
Nature. 2011 Mar 17;471(7338):363-7. Epub 2011 Mar 2.PMID:21368763
Zervoudi E, Papakyriakou A, Georgiadou D, Evnouchidou I, Gajda A, Poreba M, Salvesen GS, Drag M, Hattori A, Swevers L, Vourloumis D, Stratikos E.
Probing the S1 specificity pocket of the aminopeptidases that generate antigenic peptides.
Biochem J. 2011 Apr 15;435(2):411-20.PMID:21314638
Békés M, Prudden J, Srikumar T, Raught B, Boddy MN, Salvesen GS.
The dynamics and mechanism of sumo chain deconjugation by SUMO-specific proteases.
J Biol Chem. 2011 Jan 20.PMID: 21247896
Leverrier S, Salvesen GS, Walsh CM.
Enzymatically active single chain caspase-8 maintains T-cell survival during clonal expansion.
Cell Death Differ. 2011 Jan;18(1):90-8. Epub 2010 Jun 4. PMID:20523353
Petroski MD, Salvesen GS, Wolf DA.
Urm1 couples sulfur transfer to ubiquitin-like protein function in oxidative stress.
Proc Natl Acad Sci U S A. 2011 Jan 18.PMID: 21245332
Pop C, Oberst A, Drag M, van Raam BJ, Riedl SJ, Green DR, Salvesen GS.
FLIPL induces caspase 8 activity in the absence of interdomain caspase 8 cleavage and alters substrate specificity.
Biochem J. 2011 Jan 14;433(3):447-57. PMID: 21235526
2010 Publications
Leyva MJ, Degiacomo F, Kaltenbach LS, Holcomb J, Zhang N, Gafni J, Park H, Lo DC, Salvesen GS, Ellerby LM, Ellman JA.
Identification and evaluation of small molecule pan-caspase inhibitors in Huntington's disease models.
Chem Biol. 2010 Nov 24;17(11):1189-200.PMID: 21095569
Chekeni FB, Elliott MR, Sandilos JK, Walk SF, Kinchen JM, Lazarowski ER, Armstrong AJ, Penuela S, Laird DW, Salvesen GS, Isakson BE, Bayliss DA, Ravichandran KS.
Pannexin 1 channels mediate 'find-me' signal release and membrane permeability during apoptosis.
Nature. 2010 Oct 14;467(7317):863-7.PMID: 20944749
Bratton SB, Salvesen GS.
Regulation of the Apaf-1-caspase-9 apoptosome.
J Cell Sci. 2010 Oct 1;123(Pt 19):3209-14. PMID: 20844150
Shu CW, Drag M, Bekes M, Zhai D, Salvesen GS, Reed JC.
Synthetic substrates for measuring activity of autophagy proteases: autophagins (Atg4).
Autophagy. 2010 Oct 1;6(7):936-47. Epub 2010 Oct 19. PMID: 20818167
Kolli N, Mikolajczyk J, Drag M, Mukhopadhyay D, Moffatt N, Dasso M, Salvesen G, Wilkinson KD.
Distribution and paralogue specificity of mammalian deSUMOylating enzymes.
Biochem J. 2010 Sep 1;430(2):335-44. PMID:20590526
Drag M, Salvesen GS.
Emerging principles in protease-based drug discovery.
Nat Rev Drug Discov. 2010 Sep;9(9):690-701. Review. PMID: 20811381
Uhlmann F, Salvesen G.
Divide and die another day.
Curr Opin Cell Biol. 2010 Dec;22(6):764-5. Epub 2010 Sep 23. PMID:20864325
Wachmann K, Pop C, van Raam BJ, Drag M, Mace PD, Snipas SJ, Zmasek C, Schwarzenbacher R, Salvesen GS, Riedl SJ.
Activation and specificity of human caspase-10.
Biochemistry. 2010 Sep 28;49(38):8307-15. PMID: 20795673
Nakamura T, Wang L, Wong CC, Scott FL, Eckelman BP, Han X, Tzitzilonis C, Meng F, Gu Z, Holland EA, Clemente AT, Okamoto S, Salvesen GS, Riek R, Yates JR 3rd, Lipton SA.
Transnitrosylation of XIAP regulates caspase-dependent neuronal cell death.
Mol Cell. 2010 Jul 30;39(2):184-95. PMID: 20670888
Enoksson M, Salvesen GS.
Metacaspases are not caspases--always doubt.
Cell Death Differ. 2010 Aug;17(8):1221. PMID: 20622886
Oberst A, Pop C, Tremblay AG, Blais V, Denault JB, Salvesen GS, Green DR.
Inducible dimerization and inducible cleavage reveal a requirement for both processes in caspase-8 activation.
J Biol Chem. 2010 May 28;285(22):16632-42. Epub 2010 Mar 22. PMID: 20308068
Grzywa R, Oleksyszyn J, Salvesen GS, Drag M.
Identification of very potent inhibitor of human aminopeptidase N (CD13).
Bioorg Med Chem Lett. 2010 Apr 15;20(8):2497-9. Epub 2010 Mar 4.PMID: 20307982
van Raam BJ, Salvesen GS.
Transferring death: a role for tRNA in apoptosis regulation.
Mol Cell. 2010 Mar 12;37(5):591-2. PMID: 20227362
Staflin K, Krueger JS, Hachmann J, Forsyth JS, Lorger M, Steiniger SC, Mee J, Pop C, Salvesen GS, Janda KD, Felding-Habermann B.
Targeting activated integrin alphavbeta3 with patient-derived antibodies impacts late-stage multiorgan metastasis.
Clin Exp Metastasis. 2010 Apr;27(4):217-31. Epub 2010 Mar 12. PMID: 20225083
Zhai D, Yu E, Jin C, Welsh K, Shiau CW, Chen L, Salvesen GS, Liddington R, Reed JC.
Vaccinia virus protein F1L is a caspase-9 inhibitor.
J Biol Chem. 2010 Feb 19;285(8):5569-80. Epub 2009 Dec 18. PMID: 20022954
Drag M, Bogyo M, Ellman JA, Salvesen GS.
Aminopeptidase fingerprints, an integrated approach for identification of good substrates and optimal inhibitors.
J Biol Chem. 2010 Jan 29;285(5):3310-8. Epub 2009 Nov 30. PMID: 19948737
Leyva MJ, Degiacomo F, Kaltenbach LS, Holcomb J, Zhang N, Gafni J, Park H, Lo DC, Salvesen GS, Ellerby LM, Ellman JA.
Identification and evaluation of small molecule pan-caspase inhibitors in Huntington's disease models.
Chem Biol. 2010 Nov 24;17(11):1189-200.PMID: 21095569
Chekeni FB, Elliott MR, Sandilos JK, Walk SF, Kinchen JM, Lazarowski ER, Armstrong AJ, Penuela S, Laird DW, Salvesen GS, Isakson BE, Bayliss DA, Ravichandran KS.
Pannexin 1 channels mediate 'find-me' signal release and membrane permeability during apoptosis.
Nature. 2010 Oct 14;467(7317):863-7.PMID: 20944749
Bratton SB, Salvesen GS.
Regulation of the Apaf-1-caspase-9 apoptosome.
J Cell Sci. 2010 Oct 1;123(Pt 19):3209-14. PMID: 20844150
Shu CW, Drag M, Bekes M, Zhai D, Salvesen GS, Reed JC.
Synthetic substrates for measuring activity of autophagy proteases: autophagins (Atg4).
Autophagy. 2010 Oct 1;6(7):936-47. Epub 2010 Oct 19. PMID: 20818167
Kolli N, Mikolajczyk J, Drag M, Mukhopadhyay D, Moffatt N, Dasso M, Salvesen G, Wilkinson KD.
Distribution and paralogue specificity of mammalian deSUMOylating enzymes.
Biochem J. 2010 Sep 1;430(2):335-44. PMID:20590526
Drag M, Salvesen GS.
Emerging principles in protease-based drug discovery.
Nat Rev Drug Discov. 2010 Sep;9(9):690-701. Review. PMID: 20811381
Uhlmann F, Salvesen G.
Divide and die another day.
Curr Opin Cell Biol. 2010 Dec;22(6):764-5. Epub 2010 Sep 23. PMID:20864325
Wachmann K, Pop C, van Raam BJ, Drag M, Mace PD, Snipas SJ, Zmasek C, Schwarzenbacher R, Salvesen GS, Riedl SJ.
Activation and specificity of human caspase-10.
Biochemistry. 2010 Sep 28;49(38):8307-15. PMID: 20795673
Nakamura T, Wang L, Wong CC, Scott FL, Eckelman BP, Han X, Tzitzilonis C, Meng F, Gu Z, Holland EA, Clemente AT, Okamoto S, Salvesen GS, Riek R, Yates JR 3rd, Lipton SA.
Transnitrosylation of XIAP regulates caspase-dependent neuronal cell death.
Mol Cell. 2010 Jul 30;39(2):184-95. PMID: 20670888
Enoksson M, Salvesen GS.
Metacaspases are not caspases--always doubt.
Cell Death Differ. 2010 Aug;17(8):1221. PMID: 20622886
Oberst A, Pop C, Tremblay AG, Blais V, Denault JB, Salvesen GS, Green DR.
Inducible dimerization and inducible cleavage reveal a requirement for both processes in caspase-8 activation.
J Biol Chem. 2010 May 28;285(22):16632-42. Epub 2010 Mar 22. PMID: 20308068
Grzywa R, Oleksyszyn J, Salvesen GS, Drag M.
Identification of very potent inhibitor of human aminopeptidase N (CD13).
Bioorg Med Chem Lett. 2010 Apr 15;20(8):2497-9. Epub 2010 Mar 4.PMID: 20307982
van Raam BJ, Salvesen GS.
Transferring death: a role for tRNA in apoptosis regulation.
Mol Cell. 2010 Mar 12;37(5):591-2. PMID: 20227362
Staflin K, Krueger JS, Hachmann J, Forsyth JS, Lorger M, Steiniger SC, Mee J, Pop C, Salvesen GS, Janda KD, Felding-Habermann B.
Targeting activated integrin alphavbeta3 with patient-derived antibodies impacts late-stage multiorgan metastasis.
Clin Exp Metastasis. 2010 Apr;27(4):217-31. Epub 2010 Mar 12. PMID: 20225083
Zhai D, Yu E, Jin C, Welsh K, Shiau CW, Chen L, Salvesen GS, Liddington R, Reed JC.
Vaccinia virus protein F1L is a caspase-9 inhibitor.
J Biol Chem. 2010 Feb 19;285(8):5569-80. Epub 2009 Dec 18. PMID: 20022954
Drag M, Bogyo M, Ellman JA, Salvesen GS.
Aminopeptidase fingerprints, an integrated approach for identification of good substrates and optimal inhibitors.
J Biol Chem. 2010 Jan 29;285(5):3310-8. Epub 2009 Nov 30. PMID: 19948737
2009 Publications
Walters J, Pop C, Scott FL, Drag M, Swartz P, Mattos C, Salvesen GS, Clark AC.
A constitutively active and uninhibitable caspase-3 zymogen efficiently induces apoptosis.
Biochem J. 2009 Dec 10;424(3):335-45. PMID: 19788411
Moen I, Tronstad KJ, Kolmannskog O, Salvesen GS, Reed RK, Stuhr LE.
Hyperoxia increases the uptake of 5-fluorouracil in mammary tumors independently of changes in interstitial fluid pressure and tumor stroma.
BMC Cancer. 2009 Dec 17;9:446. PMID:20017908
Timmer JC, Zhu W, Pop C, Regan T, Snipas SJ, Eroshkin AM, Riedl SJ, Salvesen GS.
Structural and kinetic determinants of protease substrates.
Nat Struct Mol Biol. 2009 Sep 20. PMID: 19767749
Salvesen GS, Riedl SJ.
Structure of the Fas/FADD complex: A conditional death domain complex mediating signaling by receptor clustering.
Cell Cycle. 2009 Sep 30;8(17). PMID: 19652545
Pop C, Salvesen GS.
Human caspases: activation, specificity, and regulation.
J Biol Chem. 2009 Aug 14;284(33):21777-81. Epub 2009 May 26. PMID: 19473994
Cimadamore F, Curchoe CL, Alderson N, Scott F, Salvesen G, Terskikh AV.
Nicotinamide rescues human embryonic stem cell-derived neuroectoderm from parthanatic cell death.
Stem Cells. 2009 Aug;27(8):1772-81. PMID:19544437
Békés M, Salvesen GS.
The CULt of caspase-8 ubiquitination.
Cell. 2009 May 15;137(4):604-6. PMID: 19450509
Zhu S, Goeres J, Sixt KM, Békés M, Zhang XD, Salvesen GS, Matunis MJ.
Protection from isopeptidase-mediated deconjugation regulates paralog-selective sumoylation of RanGAP1.
Mol Cell. 2009 Mar 13;33(5):570-80. PMID: 19285941
Scott FL, Stec B, Pop C, Dobaczewska MK, Lee JJ, Monosov E, Robinson H, Salvesen GS, Schwarzenbacher R, Riedl SJ.
The Fas-FADD death domain complex structure unravels signalling by receptor clustering.
Nature. 2009 Feb 19;457(7232):1019-22. Epub 2008 Dec 31. PMID: 19118384
Timmer AM, Timmer JC, Pence MA, Hsu LC, Ghochani M, Frey TG, Karin M, Salvesen GS, Nizet V.
Streptolysin o promotes group a streptococcus immune evasion by accelerated macrophage apoptosis.
J Biol Chem. 2009 Jan 9;284(2):862-71. Epub 2008 Nov 11. PMID: 19001420
Walters J, Pop C, Scott FL, Drag M, Swartz P, Mattos C, Salvesen GS, Clark AC.
A constitutively active and uninhibitable caspase-3 zymogen efficiently induces apoptosis.
Biochem J. 2009 Dec 10;424(3):335-45. PMID: 19788411
Moen I, Tronstad KJ, Kolmannskog O, Salvesen GS, Reed RK, Stuhr LE.
Hyperoxia increases the uptake of 5-fluorouracil in mammary tumors independently of changes in interstitial fluid pressure and tumor stroma.
BMC Cancer. 2009 Dec 17;9:446. PMID:20017908
Timmer JC, Zhu W, Pop C, Regan T, Snipas SJ, Eroshkin AM, Riedl SJ, Salvesen GS.
Structural and kinetic determinants of protease substrates.
Nat Struct Mol Biol. 2009 Sep 20. PMID: 19767749
Salvesen GS, Riedl SJ.
Structure of the Fas/FADD complex: A conditional death domain complex mediating signaling by receptor clustering.
Cell Cycle. 2009 Sep 30;8(17). PMID: 19652545
Pop C, Salvesen GS.
Human caspases: activation, specificity, and regulation.
J Biol Chem. 2009 Aug 14;284(33):21777-81. Epub 2009 May 26. PMID: 19473994
Cimadamore F, Curchoe CL, Alderson N, Scott F, Salvesen G, Terskikh AV.
Nicotinamide rescues human embryonic stem cell-derived neuroectoderm from parthanatic cell death.
Stem Cells. 2009 Aug;27(8):1772-81. PMID:19544437
Békés M, Salvesen GS.
The CULt of caspase-8 ubiquitination.
Cell. 2009 May 15;137(4):604-6. PMID: 19450509
Zhu S, Goeres J, Sixt KM, Békés M, Zhang XD, Salvesen GS, Matunis MJ.
Protection from isopeptidase-mediated deconjugation regulates paralog-selective sumoylation of RanGAP1.
Mol Cell. 2009 Mar 13;33(5):570-80. PMID: 19285941
Scott FL, Stec B, Pop C, Dobaczewska MK, Lee JJ, Monosov E, Robinson H, Salvesen GS, Schwarzenbacher R, Riedl SJ.
The Fas-FADD death domain complex structure unravels signalling by receptor clustering.
Nature. 2009 Feb 19;457(7232):1019-22. Epub 2008 Dec 31. PMID: 19118384
Timmer AM, Timmer JC, Pence MA, Hsu LC, Ghochani M, Frey TG, Karin M, Salvesen GS, Nizet V.
Streptolysin o promotes group a streptococcus immune evasion by accelerated macrophage apoptosis.
J Biol Chem. 2009 Jan 9;284(2):862-71. Epub 2008 Nov 11. PMID: 19001420
2008 Publications
Enoksson M, Salvesen GS.
Proteolytic needles in the cellular haystack.
Nat Chem Biol. 2008 Nov;4(11):651-2. PMID: 18936746
Drag M, Mikolajczyk J, Bekes M, Reyes-Turcu FE, Ellman JA, Wilkinson KD, Salvesen GS.
Positional-scanning fluorigenic substrate libraries reveal unexpected specificity determinants of DUBs (deubiquitinating enzymes).
Biochem J. 2008 Nov 1;415(3):367-75. PMID:18601651
Drag M, Salvesen GS.
DeSUMOylating enzymes-SENPs.
IUBMB Life. 2008 Jul 29. [Epub ahead of print] PMID: 18666185
Pop C, Salvesen GS, Scott FL.
Caspase assays: identifying caspase activity and substrates in vitro and in vivo.
Methods Enzymol. 2008;446:351-67. PMID: 18603133
Droga-Mazovec G, Bojic L, Petelin A, Ivanova S, Romih R, Repnik U, Salvesen GS, Stoka V, Turk V, Turk B.
Cysteine cathepsins trigger caspase-dependent cell death through cleavage of bid and antiapoptotic Bcl-2 homologues.
J Biol Chem. 2008 Jul 4;283(27):19140-50. PMID: 18469004
Scott FL, Fuchs GJ, Boyd SE, Denault JB, Hawkins CJ, Dequiedt F, Salvesen GS.
Caspase-8 cleaves histone deacetylase 7 and abolishes its transcription repressor function.
J Biol Chem. 2008 Jul 11;283(28):19499-510.PMID: 18458084
Salvesen GS, Riedl SJ.
Caspase mechanisms.
Adv Exp Med Biol. 2008;615:13-23. Review.PMID: 18437889
Snipas SJ, Drag M, Stennicke HR, Salvesen GS.
Activation mechanism and substrate specificity of the Drosophila initiator caspase DRONC.
Cell Death Differ. 2008 Feb 29; PMID: 18309328
Eckelman BP, Drag M, Snipas SJ, Salvesen GS.
The mechanism of peptide-binding specificity of IAP BIR domains.
Cell Death Differ. 2008 Feb 1; PMID: 18239672
Denault JB, Salvesen GS.
Apoptotic caspase activation and activity.
Methods Mol Biol. 2008;414:191-220. Review. PMID: 18175821
McStay GP, Salvesen GS, Green DR.
Overlapping cleavage motif selectivity of caspases: implications for analysis of apoptotic pathways.
Cell Death Differ. 2008 Feb;15(2):322-31. PMID: 17975551
Drag M, Mikolajczyk J, Krishnakumar IM, Huang Z, Salvesen GS.
Activity profiling of human deSUMOylating enzymes (SENPs) with synthetic substrates suggests an unexpected specificity of two newly characterized members of the family.
Biochem J. 2008 Jan 15;409(2):461-9. PMID: 17916063
Enoksson M, Salvesen GS.
Proteolytic needles in the cellular haystack.
Nat Chem Biol. 2008 Nov;4(11):651-2. PMID: 18936746
Drag M, Mikolajczyk J, Bekes M, Reyes-Turcu FE, Ellman JA, Wilkinson KD, Salvesen GS.
Positional-scanning fluorigenic substrate libraries reveal unexpected specificity determinants of DUBs (deubiquitinating enzymes).
Biochem J. 2008 Nov 1;415(3):367-75. PMID:18601651
Drag M, Salvesen GS.
DeSUMOylating enzymes-SENPs.
IUBMB Life. 2008 Jul 29. [Epub ahead of print] PMID: 18666185
Pop C, Salvesen GS, Scott FL.
Caspase assays: identifying caspase activity and substrates in vitro and in vivo.
Methods Enzymol. 2008;446:351-67. PMID: 18603133
Droga-Mazovec G, Bojic L, Petelin A, Ivanova S, Romih R, Repnik U, Salvesen GS, Stoka V, Turk V, Turk B.
Cysteine cathepsins trigger caspase-dependent cell death through cleavage of bid and antiapoptotic Bcl-2 homologues.
J Biol Chem. 2008 Jul 4;283(27):19140-50. PMID: 18469004
Scott FL, Fuchs GJ, Boyd SE, Denault JB, Hawkins CJ, Dequiedt F, Salvesen GS.
Caspase-8 cleaves histone deacetylase 7 and abolishes its transcription repressor function.
J Biol Chem. 2008 Jul 11;283(28):19499-510.PMID: 18458084
Salvesen GS, Riedl SJ.
Caspase mechanisms.
Adv Exp Med Biol. 2008;615:13-23. Review.PMID: 18437889
Snipas SJ, Drag M, Stennicke HR, Salvesen GS.
Activation mechanism and substrate specificity of the Drosophila initiator caspase DRONC.
Cell Death Differ. 2008 Feb 29; PMID: 18309328
Eckelman BP, Drag M, Snipas SJ, Salvesen GS.
The mechanism of peptide-binding specificity of IAP BIR domains.
Cell Death Differ. 2008 Feb 1; PMID: 18239672
Denault JB, Salvesen GS.
Apoptotic caspase activation and activity.
Methods Mol Biol. 2008;414:191-220. Review. PMID: 18175821
McStay GP, Salvesen GS, Green DR.
Overlapping cleavage motif selectivity of caspases: implications for analysis of apoptotic pathways.
Cell Death Differ. 2008 Feb;15(2):322-31. PMID: 17975551
Drag M, Mikolajczyk J, Krishnakumar IM, Huang Z, Salvesen GS.
Activity profiling of human deSUMOylating enzymes (SENPs) with synthetic substrates suggests an unexpected specificity of two newly characterized members of the family.
Biochem J. 2008 Jan 15;409(2):461-9. PMID: 17916063
2007 Publications
Denault JB, Drag M, Salvesen GS, Alves J, Heidt AB, Deveraux Q, Harris JL.
Small molecules not direct activators of caspases.
Nat Chem Biol. 2007 Sep;3(9):519; author reply 520. N PMID: 17710090
Truscott M, Denault JB, Goulet B, Leduy L, Salvesen GS, Nepveu A.
Carboxy-terminal proteolytic processing of CUX1 by a caspase enables transcriptional activation in proliferating cells.
J Biol Chem. 2007 Aug 6; PMID: 17681953
Salvesen GS, Riedl SJ.
Caspase inhibition, specifically.
Structure. 2007 May;15(5):513-4. PMID:17502096
Wu YI, Munshi HG, Snipas SJ, Salvesen GS, Fridman R, Stack MS.
Activation-coupled membrane-type 1 matrix metalloproteinase membrane trafficking.
Biochem J. 2007 Oct 15;407(2):171-7. PMID: 17650075
Timmer JC, Enoksson M, Wildfang E, Zhu W, Igarashi Y, Denault JB, Ma Y, Dummitt B, Chang YH, Mast AE, Eroshkin A, Smith JW, Tao WA, Salvesen GS.
Profiling constitutive proteolytic events in vivo.
Biochem J. 2007 Oct 1;407(1):41-8. PMID: 17650073
Mikolajczyk J, Drag M, Bekes M, Cao JT, Ronai Z, Salvesen GS.
Small Ubiquitin-related Modifier (SUMO)-specific Proteases: PROFILING THE SPECIFICITIES AND ACTIVITIES OF HUMAN SENPs.
J Biol Chem. 2007 Sep 7;282(36):26217-24. Epub 2007 Jun 25. PMID: 17591783
Denault JB, Eckelman BP, Shin H, Pop C, Salvesen GS.
Caspase 3 attenuates XIAP (X-linked inhibitor of apoptosis protein)-mediated inhibition of caspase 9.
Biochem J. 2007 Jul 1;405(1):11-9.PMID:17437405
Enoksson M, Li J, Ivancic MM, Timmer JC, Wildfang E, Eroshkin A, Salvesen GS, Tao WA.
Identification of Proteolytic Cleavage Sites by Quantitative Proteomics.
J Proteome Res. 2007 Jun 5; PMID: 17547438
Riedl SJ, Salvesen GS.
The apoptosome: signalling platform of cell death.
Nat Rev Mol Cell Biol. 2007 Mar 21; PMID: 17377525
Pop C, Fitzgerald P, Green DR, Salvesen GS.
Role of Proteolysis in Caspase-8 Activation and Stabilization.
Biochemistry. 2007 Mar 20; PMID: 17371051
Denault JB, Drag M, Salvesen GS, Alves J, Heidt AB, Deveraux Q, Harris JL.
Small molecules not direct activators of caspases.
Nat Chem Biol. 2007 Sep;3(9):519; author reply 520. N PMID: 17710090
Truscott M, Denault JB, Goulet B, Leduy L, Salvesen GS, Nepveu A.
Carboxy-terminal proteolytic processing of CUX1 by a caspase enables transcriptional activation in proliferating cells.
J Biol Chem. 2007 Aug 6; PMID: 17681953
Salvesen GS, Riedl SJ.
Caspase inhibition, specifically.
Structure. 2007 May;15(5):513-4. PMID:17502096
Wu YI, Munshi HG, Snipas SJ, Salvesen GS, Fridman R, Stack MS.
Activation-coupled membrane-type 1 matrix metalloproteinase membrane trafficking.
Biochem J. 2007 Oct 15;407(2):171-7. PMID: 17650075
Timmer JC, Enoksson M, Wildfang E, Zhu W, Igarashi Y, Denault JB, Ma Y, Dummitt B, Chang YH, Mast AE, Eroshkin A, Smith JW, Tao WA, Salvesen GS.
Profiling constitutive proteolytic events in vivo.
Biochem J. 2007 Oct 1;407(1):41-8. PMID: 17650073
Mikolajczyk J, Drag M, Bekes M, Cao JT, Ronai Z, Salvesen GS.
Small Ubiquitin-related Modifier (SUMO)-specific Proteases: PROFILING THE SPECIFICITIES AND ACTIVITIES OF HUMAN SENPs.
J Biol Chem. 2007 Sep 7;282(36):26217-24. Epub 2007 Jun 25. PMID: 17591783
Denault JB, Eckelman BP, Shin H, Pop C, Salvesen GS.
Caspase 3 attenuates XIAP (X-linked inhibitor of apoptosis protein)-mediated inhibition of caspase 9.
Biochem J. 2007 Jul 1;405(1):11-9.PMID:17437405
Enoksson M, Li J, Ivancic MM, Timmer JC, Wildfang E, Eroshkin A, Salvesen GS, Tao WA.
Identification of Proteolytic Cleavage Sites by Quantitative Proteomics.
J Proteome Res. 2007 Jun 5; PMID: 17547438
Riedl SJ, Salvesen GS.
The apoptosome: signalling platform of cell death.
Nat Rev Mol Cell Biol. 2007 Mar 21; PMID: 17377525
Pop C, Fitzgerald P, Green DR, Salvesen GS.
Role of Proteolysis in Caspase-8 Activation and Stabilization.
Biochemistry. 2007 Mar 20; PMID: 17371051
2006 Publications
Timmer JC, Salvesen GS.
Caspase substrates.
Cell Death Differ. 2006 Nov 3;PMID: 17082814
Dobo J, Swanson R, Salvesen GS, Olson ST, Gettins PG.
CrmA inhibition of initiator caspases results in covalent complex formation and dissociation of the caspase tetramer.
J Biol Chem. 2006 Oct 19; PMID: 17052983
Eckelman BP, Salvesen GS, Scott FL.
Human inhibitor of apoptosis proteins: why XIAP is the black sheep of the family.
EMBO Rep. 2006 Oct;7(10):988-94. PMID: 17016456
Pop C, Salvesen GS.
The nematode death machine in 3D.
Cell. 2005 Oct 21;123(2):192-3. PMID:16239138
Ekici OD, Li ZZ, Campbell AJ, James KE, Asgian JL, Mikolajczyk J, Salvesen GS, Ganesan R, Jelakovic S, Grutter MG, Powers JC.
Design, synthesis, and evaluation of aza-peptide Michael acceptors as selective and potent inhibitors of caspases-2, -3, -6, -7, -8, -9, and -10.
J Med Chem. 2006 Sep 21;49(19):5728-49. PMID: 16970398
Denault JB, Bekes M, Scott FL, Sexton KM, Bogyo M, Salvesen GS.
Engineered hybrid dimers: tracking the activation pathway of caspase-7.
Mol Cell. 2006 Aug;23(4):523-33. PMID: 16916640
Berger AB, Witte MD, Denault JB, Sadaghiani AM, Sexton KM, Salvesen GS, Bogyo M.
Identification of early intermediates of caspase activation using selective inhibitors and activity-based probes.
Mol Cell. 2006 Aug;23(4):509-21. PMID: 16916639
Kato D, Boatright KM, Berger AB, Nazif T, Blum G, Ryan C, Chehade KA, Salvesen GS, Bogyo M.
Activity-based probes that target diverse cysteine protease families.
Nat Chem Biol. 2005 Jun;1(1):33-8. Epub 2005 May 24. PMID:16407991
Pop C, Timmer J, Sperandio S, Salvesen GS.
The apoptosome activates caspase-9 by dimerization.
Mol Cell. 2006 Apr 21;22(2):269-75. PMID: 16630894
Gregorc U, Dobersek A, Salvesen GS, Turk V, Turk B, Kopitar-Jerala N.
A novel caspase-7 specific monoclonal antibody.
Immunol Lett. 2005 Apr 15;98(1):167-9. PMID:15849872
Stennicke HR, Salvesen GS.
Chemical ligation--an unusual paradigm in protease inhibition.
Mol Cell. 2006 Mar 17;21(6):727-8. Review. PMID:16543139
Brendan P. Eckelman and Guy S. Salvesen
The Human Anti-apoptotic Proteins cIAP1 and cIAP2 Bind but Do Not Inhibit Caspases
J. Biol. Chem. 2006 281: 3254-3260. First Published on December 8, 2005; doi:10.1074/jbc.M510863200
Timmer JC, Salvesen GS.
Caspase substrates.
Cell Death Differ. 2006 Nov 3;PMID: 17082814
Dobo J, Swanson R, Salvesen GS, Olson ST, Gettins PG.
CrmA inhibition of initiator caspases results in covalent complex formation and dissociation of the caspase tetramer.
J Biol Chem. 2006 Oct 19; PMID: 17052983
Eckelman BP, Salvesen GS, Scott FL.
Human inhibitor of apoptosis proteins: why XIAP is the black sheep of the family.
EMBO Rep. 2006 Oct;7(10):988-94. PMID: 17016456
Pop C, Salvesen GS.
The nematode death machine in 3D.
Cell. 2005 Oct 21;123(2):192-3. PMID:16239138
Ekici OD, Li ZZ, Campbell AJ, James KE, Asgian JL, Mikolajczyk J, Salvesen GS, Ganesan R, Jelakovic S, Grutter MG, Powers JC.
Design, synthesis, and evaluation of aza-peptide Michael acceptors as selective and potent inhibitors of caspases-2, -3, -6, -7, -8, -9, and -10.
J Med Chem. 2006 Sep 21;49(19):5728-49. PMID: 16970398
Denault JB, Bekes M, Scott FL, Sexton KM, Bogyo M, Salvesen GS.
Engineered hybrid dimers: tracking the activation pathway of caspase-7.
Mol Cell. 2006 Aug;23(4):523-33. PMID: 16916640
Berger AB, Witte MD, Denault JB, Sadaghiani AM, Sexton KM, Salvesen GS, Bogyo M.
Identification of early intermediates of caspase activation using selective inhibitors and activity-based probes.
Mol Cell. 2006 Aug;23(4):509-21. PMID: 16916639
Kato D, Boatright KM, Berger AB, Nazif T, Blum G, Ryan C, Chehade KA, Salvesen GS, Bogyo M.
Activity-based probes that target diverse cysteine protease families.
Nat Chem Biol. 2005 Jun;1(1):33-8. Epub 2005 May 24. PMID:16407991
Pop C, Timmer J, Sperandio S, Salvesen GS.
The apoptosome activates caspase-9 by dimerization.
Mol Cell. 2006 Apr 21;22(2):269-75. PMID: 16630894
Gregorc U, Dobersek A, Salvesen GS, Turk V, Turk B, Kopitar-Jerala N.
A novel caspase-7 specific monoclonal antibody.
Immunol Lett. 2005 Apr 15;98(1):167-9. PMID:15849872
Stennicke HR, Salvesen GS.
Chemical ligation--an unusual paradigm in protease inhibition.
Mol Cell. 2006 Mar 17;21(6):727-8. Review. PMID:16543139
Brendan P. Eckelman and Guy S. Salvesen
The Human Anti-apoptotic Proteins cIAP1 and cIAP2 Bind but Do Not Inhibit Caspases
J. Biol. Chem. 2006 281: 3254-3260. First Published on December 8, 2005; doi:10.1074/jbc.M510863200
2005 Publications
Maryla Krajewska, Hoguen Kim, Eunah Shin, Susan Kennedy, Michael J. Duffy, Yick F. Wong, David Marr, Jowita Mikolajczyk, Ahmed Shabaik, Ivo Meinhold-Heerlein, Xianshu Huang, Steven Banares, Hirad Hedayat, John C. Reed, and Stan Krajewski
Tumor-Associated Alterations in Caspase-14 Expression in Epithelial Malignancies
Clin Cancer Res 2005 11: 5462-5471.
Bruckner S, Rhamouni S, Tautz L, Denault JB, Alonso A, Becattini B, Salvesen GS, Mustelin T.
Yersinia phosphatase induces mitochondrially dependent apoptosis of T cells.
J Biol Chem. 2005 Mar 18;280(11):10388-94. Epub 2005 Jan 4. PMID:15632192
Simonovic M, Denault JB, Salvesen GS, Volz K, Gettins PG.
Lack of involvement of strand s1'A of the viral serpin CrmA in anti-apoptotic or caspase-inhibitory functions.
Arch Biochem Biophys. 2005 Aug 1;440(1):1-9. PMID: 15993378
Fiona L Scott, Jean-Bernard Denault, Stefan J Riedl, Hwain Shin, Martin Renatus, and Guy S Salvesen
XIAP inhibits caspase-3 and -7 using two binding sites: evolutionarily conserved mechanism of IAPs
EMBO J., Feb 2005; 24: 645 - 655.
Maryla Krajewska, Hoguen Kim, Eunah Shin, Susan Kennedy, Michael J. Duffy, Yick F. Wong, David Marr, Jowita Mikolajczyk, Ahmed Shabaik, Ivo Meinhold-Heerlein, Xianshu Huang, Steven Banares, Hirad Hedayat, John C. Reed, and Stan Krajewski
Tumor-Associated Alterations in Caspase-14 Expression in Epithelial Malignancies
Clin Cancer Res 2005 11: 5462-5471.
Bruckner S, Rhamouni S, Tautz L, Denault JB, Alonso A, Becattini B, Salvesen GS, Mustelin T.
Yersinia phosphatase induces mitochondrially dependent apoptosis of T cells.
J Biol Chem. 2005 Mar 18;280(11):10388-94. Epub 2005 Jan 4. PMID:15632192
Simonovic M, Denault JB, Salvesen GS, Volz K, Gettins PG.
Lack of involvement of strand s1'A of the viral serpin CrmA in anti-apoptotic or caspase-inhibitory functions.
Arch Biochem Biophys. 2005 Aug 1;440(1):1-9. PMID: 15993378
Fiona L Scott, Jean-Bernard Denault, Stefan J Riedl, Hwain Shin, Martin Renatus, and Guy S Salvesen
XIAP inhibits caspase-3 and -7 using two binding sites: evolutionarily conserved mechanism of IAPs
EMBO J., Feb 2005; 24: 645 - 655.
2004 Publications
Snipas SJ,Wildfang E, Nazif T, Christensen L,Boatright KM,Bogyo M,Stennicke HR, Salvesen GS.
Characteristics of the caspase-like catalytic domain of human paracaspase.
Biological Chemistry 2004 Nov;385 1093-1098.
Vucic D, Franklin MC, Wallweber HJ, Das K, Eckelman BP, Shin H, Elliott LO, Kadkhodayan S, Deshayes K, Salvesen G, Fairbrother WJ.
Engineering ML-IAP to produce an extraordinarily potent caspase-9 inhibitor: implications for Smac-dependent anti-apoptotic activity of ML-IAP.
Biochem J. 2004 Oct 15 PMID: 15485396
Shin H, Renatus M, Eckelman BP, Nunes VA, Sampaio CA, Salvesen GS.
The BIR domain of IAP-like protein 2 is conformationally unstable: implications for caspase inhibition.
Biochem J. 2004 Oct 15 PMID: 15485395
Fuentes-Prior P, Salvesen GS.
The protein structures that shape caspase-activity, specificity, activation, and inhibition.
Biochem J. 2004 Sep 27; Pt PMID: 15450003
Krajewska M, Rosenthal RE, Mikolajczyk J, Stennicke HR, Wiesenthal T, Mai J, Naito M, Salvesen GS, Reed JC, Fiskum G, Krajewski S.
Early processing of Bid and caspase-6, -8, -10, -14 in the canine brain during cardiac arrest and resuscitation.
Exp Neurol. 2004 Oct;189(2):261-79. PMID: 15380478
Wilkinson JC, Wilkinson AS, Scott FL, Csomos RA, Salvesen GS, Duckett CS.
Neutralization of Smac/Diablo by IAPs: a caspase-independent mechanism for apoptotic inhibition.
J Biol Chem. 2004 Sep 15 PMID: 15371416
Mikolajczyk J, Scott FL, Krajewski S, Sutherlin DP, Salvesen GS.
Activation and substrate specificity of caspase-14.
Biochemistry. 2004 Aug 17;43(32):10560-9. PMID: 15301553
Dohi T, Okada K, Xia F, Wilford CE, Samuel T, Welsh K, Marusawa H, Zou H, Armstrong R, Matsuzawa S, Salvesen GS, Reed JC, Altieri DC.
An IAP-IAP complex inhibits apoptosis.
J Biol Chem. 2004 Aug 13;279(33):34087-90. PMID: 15218035
Boatright KM, Deis C, Denault JB, Sutherlin DP, Salvesen GS.
Activation of caspases-8 and -10 by FLIP(L).
Biochem J. 2004 Sep 1;382(Pt 2):651-7. PMID: 15209560
Salvesen GS, Abrams JM.
Caspase activation - stepping on the gas or releasing the brakes? Lessons from humans and flies.
Oncogene. 2004 Apr 12;23(16):2774-84. Review. PMID: 15077141
Denault JB, Boatright K.
Apoptosis in Biochemistry and Structural Biology.
3-8 February 2004, Keystone, CO, USA.
IDrugs. 2004 Apr;7(4):315-7.PMID: 15057633
Ekici OD, Gotz MG, James KE, Li ZZ, Rukamp BJ, Asgian JL, Caffrey CR, Hansell E, Dvorak J, McKerrow JH, Potempa J, Travis J, Mikolajczyk J, Salvesen GS, Powers JC.
Aza-peptide Michael acceptors: a new class of inhibitors specific for caspases and other clan CD cysteine proteases.
J Med Chem. 2004 Apr 8;47(8):1889-92. PMID: 15055989
James KE, Asgian JL, Li ZZ, Ekici OD, Rubin JR, Mikolajczyk J, Salvesen GS, Powers JC.
Design, synthesis, and evaluation of aza-peptide epoxides as selective and potent inhibitors of caspases-1, -3, -6, and -8.
J Med Chem. 2004 Mar 11;47(6):1553-74. PMID: 14998341
Pedersen IM, Zapata JM, Samuel T, Scott FL, Salvesen GS, Honda T, Gribble GW, Suh N, Sporn MB, Kipps TJ, Reed JC.
Retraction: The triterpenoid CDDO-Imidazolide induces apoptosis and enhances fludarabine-induced apoptosis of CLL B-cells.
Blood. 2004 Aug 15;104(4):932. Epub 2004 Jan 22. PMID: 14739219
Wu YI, Munshi HG, Sen R, Snipas SJ, Salvesen GS, Fridman R, Stack MS.
Glycosylation broadens the substrate profile of membrane type 1 matrix metalloproteinase.
J Biol Chem. 2004 Feb 27;279(9):8278-89. PMID: 14670950
Cirman T, Oresic K, Mazovec GD, Turk V, Reed JC, Myers RM, Salvesen GS, Turk B.
Selective disruption of lysosomes in HeLa cells triggers apoptosis mediated by cleavage of Bid by multiple papain-like lysosomal cathepsins.
J Biol Chem. 2004 Jan 30;279(5):3578-87. PMID: 14581476
Schimmer AD, Welsh K, Pinilla C, Wang Z, Krajewska M, Bonneau MJ, Pedersen IM, Kitada S, Scott FL, Bailly-Maitre B, Glinsky G, Scudiero D, Sausville E, Salvesen G, Nefzi A, Ostresh JM, Houghten RA, Reed JC.
Small-molecule antagonists of apoptosis suppressor XIAP exhibit broad antitumor activity.
Cancer Cell. 2004 Jan;5(1):25-35. PMID:14749124
Snipas SJ,Wildfang E, Nazif T, Christensen L,Boatright KM,Bogyo M,Stennicke HR, Salvesen GS.
Characteristics of the caspase-like catalytic domain of human paracaspase.
Biological Chemistry 2004 Nov;385 1093-1098.
Vucic D, Franklin MC, Wallweber HJ, Das K, Eckelman BP, Shin H, Elliott LO, Kadkhodayan S, Deshayes K, Salvesen G, Fairbrother WJ.
Engineering ML-IAP to produce an extraordinarily potent caspase-9 inhibitor: implications for Smac-dependent anti-apoptotic activity of ML-IAP.
Biochem J. 2004 Oct 15 PMID: 15485396
Shin H, Renatus M, Eckelman BP, Nunes VA, Sampaio CA, Salvesen GS.
The BIR domain of IAP-like protein 2 is conformationally unstable: implications for caspase inhibition.
Biochem J. 2004 Oct 15 PMID: 15485395
Fuentes-Prior P, Salvesen GS.
The protein structures that shape caspase-activity, specificity, activation, and inhibition.
Biochem J. 2004 Sep 27; Pt PMID: 15450003
Krajewska M, Rosenthal RE, Mikolajczyk J, Stennicke HR, Wiesenthal T, Mai J, Naito M, Salvesen GS, Reed JC, Fiskum G, Krajewski S.
Early processing of Bid and caspase-6, -8, -10, -14 in the canine brain during cardiac arrest and resuscitation.
Exp Neurol. 2004 Oct;189(2):261-79. PMID: 15380478
Wilkinson JC, Wilkinson AS, Scott FL, Csomos RA, Salvesen GS, Duckett CS.
Neutralization of Smac/Diablo by IAPs: a caspase-independent mechanism for apoptotic inhibition.
J Biol Chem. 2004 Sep 15 PMID: 15371416
Mikolajczyk J, Scott FL, Krajewski S, Sutherlin DP, Salvesen GS.
Activation and substrate specificity of caspase-14.
Biochemistry. 2004 Aug 17;43(32):10560-9. PMID: 15301553
Dohi T, Okada K, Xia F, Wilford CE, Samuel T, Welsh K, Marusawa H, Zou H, Armstrong R, Matsuzawa S, Salvesen GS, Reed JC, Altieri DC.
An IAP-IAP complex inhibits apoptosis.
J Biol Chem. 2004 Aug 13;279(33):34087-90. PMID: 15218035
Boatright KM, Deis C, Denault JB, Sutherlin DP, Salvesen GS.
Activation of caspases-8 and -10 by FLIP(L).
Biochem J. 2004 Sep 1;382(Pt 2):651-7. PMID: 15209560
Salvesen GS, Abrams JM.
Caspase activation - stepping on the gas or releasing the brakes? Lessons from humans and flies.
Oncogene. 2004 Apr 12;23(16):2774-84. Review. PMID: 15077141
Denault JB, Boatright K.
Apoptosis in Biochemistry and Structural Biology.
3-8 February 2004, Keystone, CO, USA.
IDrugs. 2004 Apr;7(4):315-7.PMID: 15057633
Ekici OD, Gotz MG, James KE, Li ZZ, Rukamp BJ, Asgian JL, Caffrey CR, Hansell E, Dvorak J, McKerrow JH, Potempa J, Travis J, Mikolajczyk J, Salvesen GS, Powers JC.
Aza-peptide Michael acceptors: a new class of inhibitors specific for caspases and other clan CD cysteine proteases.
J Med Chem. 2004 Apr 8;47(8):1889-92. PMID: 15055989
James KE, Asgian JL, Li ZZ, Ekici OD, Rubin JR, Mikolajczyk J, Salvesen GS, Powers JC.
Design, synthesis, and evaluation of aza-peptide epoxides as selective and potent inhibitors of caspases-1, -3, -6, and -8.
J Med Chem. 2004 Mar 11;47(6):1553-74. PMID: 14998341
Pedersen IM, Zapata JM, Samuel T, Scott FL, Salvesen GS, Honda T, Gribble GW, Suh N, Sporn MB, Kipps TJ, Reed JC.
Retraction: The triterpenoid CDDO-Imidazolide induces apoptosis and enhances fludarabine-induced apoptosis of CLL B-cells.
Blood. 2004 Aug 15;104(4):932. Epub 2004 Jan 22. PMID: 14739219
Wu YI, Munshi HG, Sen R, Snipas SJ, Salvesen GS, Fridman R, Stack MS.
Glycosylation broadens the substrate profile of membrane type 1 matrix metalloproteinase.
J Biol Chem. 2004 Feb 27;279(9):8278-89. PMID: 14670950
Cirman T, Oresic K, Mazovec GD, Turk V, Reed JC, Myers RM, Salvesen GS, Turk B.
Selective disruption of lysosomes in HeLa cells triggers apoptosis mediated by cleavage of Bid by multiple papain-like lysosomal cathepsins.
J Biol Chem. 2004 Jan 30;279(5):3578-87. PMID: 14581476
Schimmer AD, Welsh K, Pinilla C, Wang Z, Krajewska M, Bonneau MJ, Pedersen IM, Kitada S, Scott FL, Bailly-Maitre B, Glinsky G, Scudiero D, Sausville E, Salvesen G, Nefzi A, Ostresh JM, Houghten RA, Reed JC.
Small-molecule antagonists of apoptosis suppressor XIAP exhibit broad antitumor activity.
Cancer Cell. 2004 Jan;5(1):25-35. PMID:14749124
2003 Publications
Boatright KM, Salvesen GS.
Mechanisms of caspase activation.
Curr Opin Cell Biol. 2003 Dec;15(6):725-31. Review. PMID: 14644197
Denault JB, Salvesen GS.
Expression, purification, and characterization of caspases.
Curr Protoc Protein Sci. 2003 Feb;Chapter 21:Unit 21.13. PMID:18429241
Saklatvala J, Nagase H, Salvesen G.
A tribute to Alan J. Barrett.
Biochem Soc Symp. 2003;(70):ix-x. PMID:14587277
Boatright KM, Salvesen GS.
Caspase activation.
Biochem Soc Symp. 2003(70):233-42. Review. PMID: 14587296
Reed JC, Doctor K, Rojas A, Zapata JM, Stehlik C, Fiorentino L, Damiano J, Roth W, Matsuzawa S, Newman R, Takayama S, Marusawa H, Xu F, Salvesen G, Godzik A; RIKEN GER Group; GSL Members.
Comparative analysis of apoptosis and inflammation genes of mice and humans.
Genome Res. 2003 Jun;13(6B):1376-88. PMID:12819136
Ryan CA, Salvesen GS.
Caspases and neuronal development.
Biol Chem. 2003 Jun;384(6):855-61. Review. PMID: 12887052
Kashkar H, Haefs C, Shin H, Hamilton-Dutoit SJ, Salvesen GS, Kronke M, Jurgensmeier JM.
XIAP-mediated caspase inhibition in Hodgkin's lymphoma-derived B cells.
J Exp Med. 2003 Jul 21;198(2):341-7. PMID: 12874265
Denault JB, Salvesen GS.
Human caspase-7 activity and regulation by its N-terminal peptide.
J Biol Chem. 2003 Sep 5;278(36):34042-50. PMID: 12824163
Shin H, Okada K, Wilkinson JC, Solomon KM, Duckett CS, Reed JC, Salvesen GS.
Identification of ubiquitination sites on the X-linked inhibitor of apoptosis protein.
Biochem J. 2003 Aug 1;373(Pt 3):965-71. PMID: 12747801
Salvesen GS, Scott FL.
Serpins are getting hotter.
Structure (Camb). 2003 Apr;11(4):364-5. PMID: 12679013
Boatright KM, Renatus M, Scott FL, Sperandio S, Shin H, Pedersen IM, Ricci JE, Edris WA, Sutherlin DP, Green DR, Salvesen GS.
A unified model for apical caspase activation.
Mol Cell. 2003 Feb;11(2):529-41. PMID: 12620239
Mikolajczyk J, Boatright KM, Stennicke HR, Nazif T, Potempa J, Bogyo M, Salvesen GS.
Sequential autolytic processing activates the zymogen of Arg-gingipain.
J Biol Chem. 2003 Mar 21;278(12):10458-64. Epub 2003 Jan 17. PMID: 12533545
Boatright KM, Salvesen GS.
Mechanisms of caspase activation.
Curr Opin Cell Biol. 2003 Dec;15(6):725-31. Review. PMID: 14644197
Denault JB, Salvesen GS.
Expression, purification, and characterization of caspases.
Curr Protoc Protein Sci. 2003 Feb;Chapter 21:Unit 21.13. PMID:18429241
Saklatvala J, Nagase H, Salvesen G.
A tribute to Alan J. Barrett.
Biochem Soc Symp. 2003;(70):ix-x. PMID:14587277
Boatright KM, Salvesen GS.
Caspase activation.
Biochem Soc Symp. 2003(70):233-42. Review. PMID: 14587296
Reed JC, Doctor K, Rojas A, Zapata JM, Stehlik C, Fiorentino L, Damiano J, Roth W, Matsuzawa S, Newman R, Takayama S, Marusawa H, Xu F, Salvesen G, Godzik A; RIKEN GER Group; GSL Members.
Comparative analysis of apoptosis and inflammation genes of mice and humans.
Genome Res. 2003 Jun;13(6B):1376-88. PMID:12819136
Ryan CA, Salvesen GS.
Caspases and neuronal development.
Biol Chem. 2003 Jun;384(6):855-61. Review. PMID: 12887052
Kashkar H, Haefs C, Shin H, Hamilton-Dutoit SJ, Salvesen GS, Kronke M, Jurgensmeier JM.
XIAP-mediated caspase inhibition in Hodgkin's lymphoma-derived B cells.
J Exp Med. 2003 Jul 21;198(2):341-7. PMID: 12874265
Denault JB, Salvesen GS.
Human caspase-7 activity and regulation by its N-terminal peptide.
J Biol Chem. 2003 Sep 5;278(36):34042-50. PMID: 12824163
Shin H, Okada K, Wilkinson JC, Solomon KM, Duckett CS, Reed JC, Salvesen GS.
Identification of ubiquitination sites on the X-linked inhibitor of apoptosis protein.
Biochem J. 2003 Aug 1;373(Pt 3):965-71. PMID: 12747801
Salvesen GS, Scott FL.
Serpins are getting hotter.
Structure (Camb). 2003 Apr;11(4):364-5. PMID: 12679013
Boatright KM, Renatus M, Scott FL, Sperandio S, Shin H, Pedersen IM, Ricci JE, Edris WA, Sutherlin DP, Green DR, Salvesen GS.
A unified model for apical caspase activation.
Mol Cell. 2003 Feb;11(2):529-41. PMID: 12620239
Mikolajczyk J, Boatright KM, Stennicke HR, Nazif T, Potempa J, Bogyo M, Salvesen GS.
Sequential autolytic processing activates the zymogen of Arg-gingipain.
J Biol Chem. 2003 Mar 21;278(12):10458-64. Epub 2003 Jan 17. PMID: 12533545
2002 Publications
Denault JB, Salvesen GS.
Caspases: keys in the ignition of cell death.
Chem Rev. 2002 Dec;102(12):4489-500. Review. PMID: 12475198
Salvesen GS.
Caspases and apoptosis.
Essays Biochem. 2002;38:9-19. Review. PMID: 12463158
Denault JB, Salvesen GS.
Caspases.
Curr Protoc Protein Sci. 2002 Feb;Chapter 21:Unit 21.8. PMID:18429233
Asgian JL, James KE, Li ZZ, Carter W, Barrett AJ, Mikolajczyk J, Salvesen GS, Powers JC.
Aza-peptide epoxides: a new class of inhibitors selective for clan CD cysteine proteases.
J Med Chem. 2002 Nov 7;45(23):4958-60. PMID: 12408706
Turk B, Turk D, Salvesen GS.
Regulating cysteine protease activity: essential role of protease inhibitors as guardians and regulators.
Curr Pharm Des. 2002;8(18):1623-37. Review. PMID: 12132995
Troy CM, Salvesen GS.
Caspases on the brain.
J Neurosci Res. 2002 Jul 15;69(2):145-50. Review. PMID: 12111795
Ryan CA, Stennicke HR, Nava VE, Burch JB, Hardwick JM, Salvesen GS.
Inhibitor specificity of recombinant and endogenous caspase-9.
Biochem J. 2002 Sep 1;366(Pt 2):595-601. PMID: 12067274
Salvesen GS, Duckett CS.
IAP proteins: blocking the road to death's door.
Nat Rev Mol Cell Biol. 2002 Jun;3(6):401-10. Review. PMID: 12042762
Lu C, Fu W, Salvesen GS, Mattson MP.
Direct cleavage of AMPA receptor subunit GluR1 and suppression of AMPA currents by caspase-3: implications for synaptic plasticity and excitotoxic neuronal death.
Neuromolecular Med. 2002;1(1):69-79. PMID: 12025817
Gil-Parrado S, Fernandez-Montalvan A, Assfalg-Machleidt I, Popp O, Bestvater F, Holloschi A, Knoch TA, Auerswald EA, Welsh K, Reed JC, Fritz H, Fuentes-Prior P, Spiess E, Salvesen GS, Machleidt W.
Ionomycin-activated calpain triggers apoptosis. A probable role for Bcl-2 family members.
J Biol Chem. 2002 Jul 26;277(30):27217-26.PMID: 12000759
Okamoto S, Li Z, Ju C, Scholzke MN, Mathews E, Cui J, Salvesen GS, Bossy-Wetzel E, Lipton SA.
Dominant-interfering forms of MEF2 generated by caspase cleavage contribute to NMDA-induced neuronal apoptosis.
Proc Natl Acad Sci U S A. 2002 Mar 19;99(6):3974-9. PMID: 11904443
Salvesen GS, Renatus M.
Apoptosome: the seven-spoked death machine.
Dev Cell. 2002 Mar;2(3):256-7. Review. PMID: 11879630
Stennicke HR, Ryan CA, Salvesen GS.
Reprieval from execution: the molecular basis of caspase inhibition.
Trends Biochem Sci. 2002 Feb;27(2):94-101. Review. PMID: 11852247
Salvesen GS.
Caspases: opening the boxes and interpreting the arrows.
Cell Death Differ. 2002 Jan;9(1):3-5. PMID: 11803369
Denault JB, Salvesen GS.
Caspases: keys in the ignition of cell death.
Chem Rev. 2002 Dec;102(12):4489-500. Review. PMID: 12475198
Salvesen GS.
Caspases and apoptosis.
Essays Biochem. 2002;38:9-19. Review. PMID: 12463158
Denault JB, Salvesen GS.
Caspases.
Curr Protoc Protein Sci. 2002 Feb;Chapter 21:Unit 21.8. PMID:18429233
Asgian JL, James KE, Li ZZ, Carter W, Barrett AJ, Mikolajczyk J, Salvesen GS, Powers JC.
Aza-peptide epoxides: a new class of inhibitors selective for clan CD cysteine proteases.
J Med Chem. 2002 Nov 7;45(23):4958-60. PMID: 12408706
Turk B, Turk D, Salvesen GS.
Regulating cysteine protease activity: essential role of protease inhibitors as guardians and regulators.
Curr Pharm Des. 2002;8(18):1623-37. Review. PMID: 12132995
Troy CM, Salvesen GS.
Caspases on the brain.
J Neurosci Res. 2002 Jul 15;69(2):145-50. Review. PMID: 12111795
Ryan CA, Stennicke HR, Nava VE, Burch JB, Hardwick JM, Salvesen GS.
Inhibitor specificity of recombinant and endogenous caspase-9.
Biochem J. 2002 Sep 1;366(Pt 2):595-601. PMID: 12067274
Salvesen GS, Duckett CS.
IAP proteins: blocking the road to death's door.
Nat Rev Mol Cell Biol. 2002 Jun;3(6):401-10. Review. PMID: 12042762
Lu C, Fu W, Salvesen GS, Mattson MP.
Direct cleavage of AMPA receptor subunit GluR1 and suppression of AMPA currents by caspase-3: implications for synaptic plasticity and excitotoxic neuronal death.
Neuromolecular Med. 2002;1(1):69-79. PMID: 12025817
Gil-Parrado S, Fernandez-Montalvan A, Assfalg-Machleidt I, Popp O, Bestvater F, Holloschi A, Knoch TA, Auerswald EA, Welsh K, Reed JC, Fritz H, Fuentes-Prior P, Spiess E, Salvesen GS, Machleidt W.
Ionomycin-activated calpain triggers apoptosis. A probable role for Bcl-2 family members.
J Biol Chem. 2002 Jul 26;277(30):27217-26.PMID: 12000759
Okamoto S, Li Z, Ju C, Scholzke MN, Mathews E, Cui J, Salvesen GS, Bossy-Wetzel E, Lipton SA.
Dominant-interfering forms of MEF2 generated by caspase cleavage contribute to NMDA-induced neuronal apoptosis.
Proc Natl Acad Sci U S A. 2002 Mar 19;99(6):3974-9. PMID: 11904443
Salvesen GS, Renatus M.
Apoptosome: the seven-spoked death machine.
Dev Cell. 2002 Mar;2(3):256-7. Review. PMID: 11879630
Stennicke HR, Ryan CA, Salvesen GS.
Reprieval from execution: the molecular basis of caspase inhibition.
Trends Biochem Sci. 2002 Feb;27(2):94-101. Review. PMID: 11852247
Salvesen GS.
Caspases: opening the boxes and interpreting the arrows.
Cell Death Differ. 2002 Jan;9(1):3-5. PMID: 11803369
2001 Publications
Riedl SJ, Fuentes-Prior P, Renatus M, Kairies N, Krapp S, Huber R, Salvesen GS, Bode W.
Structural basis for the activation of human procaspase-7.
Proc Natl Acad Sci U S A. 2001 Dec 18;98(26):14790-5. PMID: 11752425
Renatus M, Stennicke HR, Scott FL, Liddington RC, Salvesen GS.
Dimer formation drives the activation of the cell death protease caspase 9.
Proc Natl Acad Sci U S A. 2001 Dec 4;98(25):14250-5. PMID: 11734640
Katunuma N, Matsui A, Le QT, Utsumi K, Salvesen G, Ohashi A.
Novel procaspase-3 activating cascade mediated by lysoapoptases and its biological significances in apoptosis.
Adv Enzyme Regul. 2001;41:237-50. PMID:11384748
Riedl SJ, Renatus M, Snipas SJ, Salvesen GS.
Mechanism-based inactivation of caspases by the apoptotic suppressor p35.
Biochemistry. 2001 Nov 6;40(44):13274-80. PMID: 11683637
Snipas SJ, Stennicke HR, Riedl S, Potempa J, Travis J, Barrett AJ, Salvesen GS.
Inhibition of distant caspase homologues by natural caspase inhibitors.
Biochem J. 2001 Jul 15;357(Pt 2):575-80. PMID: 11439111
Silverman GA, Bird PI, Carrell RW, Church FC, Coughlin PB, Gettins PG, Irving JA, Lomas DA, Luke CJ, Moyer RW, Pemberton PA, Remold-O'Donnell E, Salvesen GS, Travis J, Whisstock JC.
The serpins are an expanding superfamily of structurally similar but functionally diverse proteins. Evolution, mechanism of inhibition, novel functions, and a revised nomenclature.
J Biol Chem. 2001 Sep 7;276(36):33293-6. Epub 2001 Jul 02. Review. PMID: 11435447
Riedl SJ, Renatus M, Schwarzenbacher R, Zhou Q, Sun C, Fesik SW, Liddington RC, Salvesen GS.
Structural basis for the inhibition of caspase-3 by XIAP.
Cell. 2001 Mar 9;104(5):791-800. PMID: 11257232
Salvesen GS.
A lysosomal protease enters the death scene.
J Clin Invest. 2001 Jan;107(1):21-2. Review. PMID: 11134173
Leo E, Deveraux QL, Buchholtz C, Welsh K, Matsuzawa S, Stennicke HR, Salvesen GS, Reed JC.
TRAF1 is a substrate of caspases activated during tumor necrosis factor receptor-alpha-induced apoptosis.
J Biol Chem. 2001 Mar 16;276(11):8087-93. PMID: 11098060
Stoka V, Turk B, Schendel SL, Kim TH, Cirman T, Snipas SJ, Ellerby LM, Bredesen D, Freeze H, Abrahamson M, Bromme D, Krajewski S, Reed JC, Yin XM, Turk V, Salvesen GS.
Lysosomal protease pathways to apoptosis. Cleavage of bid, not pro-caspases, is the most likely route.
J Biol Chem. 2001 Feb 2;276(5):3149-57. PMID: 11073962
Affar EB, Germain M, Winstall E, Vodenicharov M, Shah RG, Salvesen GS, Poirier GG.
Caspase-3-mediated processing of poly(ADP-ribose) glycohydrolase during apoptosis.
J Biol Chem. 2001 Jan 26;276(4):2935-42. PMID: 11053413
Riedl SJ, Fuentes-Prior P, Renatus M, Kairies N, Krapp S, Huber R, Salvesen GS, Bode W.
Structural basis for the activation of human procaspase-7.
Proc Natl Acad Sci U S A. 2001 Dec 18;98(26):14790-5. PMID: 11752425
Renatus M, Stennicke HR, Scott FL, Liddington RC, Salvesen GS.
Dimer formation drives the activation of the cell death protease caspase 9.
Proc Natl Acad Sci U S A. 2001 Dec 4;98(25):14250-5. PMID: 11734640
Katunuma N, Matsui A, Le QT, Utsumi K, Salvesen G, Ohashi A.
Novel procaspase-3 activating cascade mediated by lysoapoptases and its biological significances in apoptosis.
Adv Enzyme Regul. 2001;41:237-50. PMID:11384748
Riedl SJ, Renatus M, Snipas SJ, Salvesen GS.
Mechanism-based inactivation of caspases by the apoptotic suppressor p35.
Biochemistry. 2001 Nov 6;40(44):13274-80. PMID: 11683637
Snipas SJ, Stennicke HR, Riedl S, Potempa J, Travis J, Barrett AJ, Salvesen GS.
Inhibition of distant caspase homologues by natural caspase inhibitors.
Biochem J. 2001 Jul 15;357(Pt 2):575-80. PMID: 11439111
Silverman GA, Bird PI, Carrell RW, Church FC, Coughlin PB, Gettins PG, Irving JA, Lomas DA, Luke CJ, Moyer RW, Pemberton PA, Remold-O'Donnell E, Salvesen GS, Travis J, Whisstock JC.
The serpins are an expanding superfamily of structurally similar but functionally diverse proteins. Evolution, mechanism of inhibition, novel functions, and a revised nomenclature.
J Biol Chem. 2001 Sep 7;276(36):33293-6. Epub 2001 Jul 02. Review. PMID: 11435447
Riedl SJ, Renatus M, Schwarzenbacher R, Zhou Q, Sun C, Fesik SW, Liddington RC, Salvesen GS.
Structural basis for the inhibition of caspase-3 by XIAP.
Cell. 2001 Mar 9;104(5):791-800. PMID: 11257232
Salvesen GS.
A lysosomal protease enters the death scene.
J Clin Invest. 2001 Jan;107(1):21-2. Review. PMID: 11134173
Leo E, Deveraux QL, Buchholtz C, Welsh K, Matsuzawa S, Stennicke HR, Salvesen GS, Reed JC.
TRAF1 is a substrate of caspases activated during tumor necrosis factor receptor-alpha-induced apoptosis.
J Biol Chem. 2001 Mar 16;276(11):8087-93. PMID: 11098060
Stoka V, Turk B, Schendel SL, Kim TH, Cirman T, Snipas SJ, Ellerby LM, Bredesen D, Freeze H, Abrahamson M, Bromme D, Krajewski S, Reed JC, Yin XM, Turk V, Salvesen GS.
Lysosomal protease pathways to apoptosis. Cleavage of bid, not pro-caspases, is the most likely route.
J Biol Chem. 2001 Feb 2;276(5):3149-57. PMID: 11073962
Affar EB, Germain M, Winstall E, Vodenicharov M, Shah RG, Salvesen GS, Poirier GG.
Caspase-3-mediated processing of poly(ADP-ribose) glycohydrolase during apoptosis.
J Biol Chem. 2001 Jan 26;276(4):2935-42. PMID: 11053413
2000 Publications
Vucic D, Stennicke HR, Pisabarro MT, Salvesen GS, Dixit VM.
ML-IAP, a novel inhibitor of apoptosis that is preferentially expressed in human melanomas.
Curr Biol. 2000 Nov 2;10(21):1359-66. PMID: 11084335
Stennicke HR, Renatus M, Meldal M, Salvesen GS.
Internally quenched fluorescent peptide substrates disclose the subsite preferences of human caspases 1, 3, 6, 7 and 8.
Biochem J. 2000 Sep 1;350 Pt 2:563-8. PMID: 10947972
Zhou Q, Salvesen GS.
Viral caspase inhibitors CrmA and p35.
Methods Enzymol. 2000;322:143-54. PMID: 10914011
Stennicke HR, Salvesen GS.
Caspase assays.
Methods Enzymol. 2000;322:91-100. PMID: 10914007
Renatus M, Zhou Q, Stennicke HR, Snipas SJ, Turk D, Bankston LA, Liddington RC, Salvesen GS.
Crystal structure of the apoptotic suppressor CrmA in its cleaved form.
Structure Fold Des. 2000 Jul 15;8(7):789-97. PMID: 10903953
Lu DC, Rabizadeh S, Chandra S, Shayya RF, Ellerby LM, Ye X, Salvesen GS, Koo EH, Bredesen DE.
A second cytotoxic proteolytic peptide derived from amyloid beta-protein precursor.
Nat Med. 2000 Apr;6(4):397-404. PMID: 10742146
Stennicke HR, Salvesen GS.
Caspases - controlling intracellular signals by protease zymogen activation.
Biochim Biophys Acta. 2000 Mar 7;1477(1-2):299-306. Review. PMID: 10708865
Huang Q, Deveraux QL, Maeda S, Salvesen GS, Stennicke HR, Hammock BD, Reed JC.
Evolutionary conservation of apoptosis mechanisms: lepidopteran and baculoviral inhibitor of apoptosis proteins are inhibitors of mammalian caspase-9.
Proc Natl Acad Sci U S A. 2000 Feb 15;97(4):1427-32. PMID: 10677478
Vucic D, Stennicke HR, Pisabarro MT, Salvesen GS, Dixit VM.
ML-IAP, a novel inhibitor of apoptosis that is preferentially expressed in human melanomas.
Curr Biol. 2000 Nov 2;10(21):1359-66. PMID: 11084335
Stennicke HR, Renatus M, Meldal M, Salvesen GS.
Internally quenched fluorescent peptide substrates disclose the subsite preferences of human caspases 1, 3, 6, 7 and 8.
Biochem J. 2000 Sep 1;350 Pt 2:563-8. PMID: 10947972
Zhou Q, Salvesen GS.
Viral caspase inhibitors CrmA and p35.
Methods Enzymol. 2000;322:143-54. PMID: 10914011
Stennicke HR, Salvesen GS.
Caspase assays.
Methods Enzymol. 2000;322:91-100. PMID: 10914007
Renatus M, Zhou Q, Stennicke HR, Snipas SJ, Turk D, Bankston LA, Liddington RC, Salvesen GS.
Crystal structure of the apoptotic suppressor CrmA in its cleaved form.
Structure Fold Des. 2000 Jul 15;8(7):789-97. PMID: 10903953
Lu DC, Rabizadeh S, Chandra S, Shayya RF, Ellerby LM, Ye X, Salvesen GS, Koo EH, Bredesen DE.
A second cytotoxic proteolytic peptide derived from amyloid beta-protein precursor.
Nat Med. 2000 Apr;6(4):397-404. PMID: 10742146
Stennicke HR, Salvesen GS.
Caspases - controlling intracellular signals by protease zymogen activation.
Biochim Biophys Acta. 2000 Mar 7;1477(1-2):299-306. Review. PMID: 10708865
Huang Q, Deveraux QL, Maeda S, Salvesen GS, Stennicke HR, Hammock BD, Reed JC.
Evolutionary conservation of apoptosis mechanisms: lepidopteran and baculoviral inhibitor of apoptosis proteins are inhibitors of mammalian caspase-9.
Proc Natl Acad Sci U S A. 2000 Feb 15;97(4):1427-32. PMID: 10677478
1999 Publications
Deveraux QL, Stennicke HR, Salvesen GS, Reed JC.
Endogenous inhibitors of caspases.
J Clin Immunol. 1999 Nov;19(6):388-98. Review. PMID: 10634212
Stennicke HR, Salvesen GS.
Catalytic properties of the caspases.
Cell Death Differ. 1999 Nov;6(11):1054-9. Review. PMID: 10578173
Salvesen GS.
Caspase 8: igniting the death machine.
Structure Fold Des. 1999 Oct 15;7(10):R225-9. Review. PMID: 10545333
Deveraux QL, Leo E, Stennicke HR, Welsh K, Salvesen GS, Reed JC.
Cleavage of human inhibitor of apoptosis protein XIAP results in fragments with distinct specificities for caspases.
EMBO J. 1999 Oct 1;18(19):5242-51. PMID: 10508158
Salvesen GS, Dixit VM.
Caspase activation: the induced-proximity model.
Proc Natl Acad Sci U S A. 1999 Sep 28;96(20):10964-7. Review. PMID: 10500109
Germain M, Affar EB, D'Amours D, Dixit VM, Salvesen GS, Poirier GG.
Cleavage of automodified poly(ADP-ribose) polymerase during apoptosis. Evidence for involvement of caspase-7.
J Biol Chem. 1999 Oct 1;274(40):28379-84. PMID: 10497198
Wolf BB, Goldstein JC, Stennicke HR, Beere H, Amarante-Mendes GP, Salvesen GS, Green DR.
Calpain functions in a caspase-independent manner to promote apoptosis-like events during platelet activation.
Blood. 1999 Sep 1;94(5):1683-92. PMID: 10477693
Krajewski S, Krajewska M, Ellerby LM, Welsh K, Xie Z, Deveraux QL, Salvesen GS, Bredesen DE, Rosenthal RE, Fiskum G, Reed JC.
Release of caspase-9 from mitochondria during neuronal apoptosis and cerebral ischemia.
Proc Natl Acad Sci U S A. 1999 May 11;96(10):5752-7. PMID: 10318956
Stennicke HR, Salvesen GS.
Caspases: preparation and characterization.
Methods. 1999 Apr;17(4):313-9. PMID: 10196102
Salvesen GS.
Programmed cell death and the caspases.
APMIS. 1999 Jan;107(1):73-9. Review. PMID: 10190282
Chou JJ, Li H, Salvesen GS, Yuan J, Wagner G.
Solution structure of BID, an intracellular amplifier of apoptotic signaling.
Cell. 1999 Mar 5;96(5):615-24. PMID: 10089877
Ellerby LM, Andrusiak RL, Wellington CL, Hackam AS, Propp SS, Wood JD, Sharp AH, Margolis RL, Ross CA, Salvesen GS, Hayden MR, Bredesen DE.
Cleavage of atrophin-1 at caspase site aspartic acid 109 modulates cytotoxicity.
J Biol Chem. 1999 Mar 26;274(13):8730-6. PMID: 10085113
Stennicke HR, Deveraux QL, Humke EW, Reed JC, Dixit VM, Salvesen GS.
Caspase-9 can be activated without proteolytic processing.
J Biol Chem. 1999 Mar 26;274(13):8359-62. PMID: 10085063
Ellerby LM, Hackam AS, Propp SS, Ellerby HM, Rabizadeh S, Cashman NR, Trifiro MA, Pinsky L, Wellington CL, Salvesen GS, Hayden MR, Bredesen DE.
Kennedy's disease: caspase cleavage of the androgen receptor is a crucial event in cytotoxicity.
J Neurochem. 1999 Jan;72(1):185-95. PMID: 9886069
Deveraux QL, Stennicke HR, Salvesen GS, Reed JC.
Endogenous inhibitors of caspases.
J Clin Immunol. 1999 Nov;19(6):388-98. Review. PMID: 10634212
Stennicke HR, Salvesen GS.
Catalytic properties of the caspases.
Cell Death Differ. 1999 Nov;6(11):1054-9. Review. PMID: 10578173
Salvesen GS.
Caspase 8: igniting the death machine.
Structure Fold Des. 1999 Oct 15;7(10):R225-9. Review. PMID: 10545333
Deveraux QL, Leo E, Stennicke HR, Welsh K, Salvesen GS, Reed JC.
Cleavage of human inhibitor of apoptosis protein XIAP results in fragments with distinct specificities for caspases.
EMBO J. 1999 Oct 1;18(19):5242-51. PMID: 10508158
Salvesen GS, Dixit VM.
Caspase activation: the induced-proximity model.
Proc Natl Acad Sci U S A. 1999 Sep 28;96(20):10964-7. Review. PMID: 10500109
Germain M, Affar EB, D'Amours D, Dixit VM, Salvesen GS, Poirier GG.
Cleavage of automodified poly(ADP-ribose) polymerase during apoptosis. Evidence for involvement of caspase-7.
J Biol Chem. 1999 Oct 1;274(40):28379-84. PMID: 10497198
Wolf BB, Goldstein JC, Stennicke HR, Beere H, Amarante-Mendes GP, Salvesen GS, Green DR.
Calpain functions in a caspase-independent manner to promote apoptosis-like events during platelet activation.
Blood. 1999 Sep 1;94(5):1683-92. PMID: 10477693
Krajewski S, Krajewska M, Ellerby LM, Welsh K, Xie Z, Deveraux QL, Salvesen GS, Bredesen DE, Rosenthal RE, Fiskum G, Reed JC.
Release of caspase-9 from mitochondria during neuronal apoptosis and cerebral ischemia.
Proc Natl Acad Sci U S A. 1999 May 11;96(10):5752-7. PMID: 10318956
Stennicke HR, Salvesen GS.
Caspases: preparation and characterization.
Methods. 1999 Apr;17(4):313-9. PMID: 10196102
Salvesen GS.
Programmed cell death and the caspases.
APMIS. 1999 Jan;107(1):73-9. Review. PMID: 10190282
Chou JJ, Li H, Salvesen GS, Yuan J, Wagner G.
Solution structure of BID, an intracellular amplifier of apoptotic signaling.
Cell. 1999 Mar 5;96(5):615-24. PMID: 10089877
Ellerby LM, Andrusiak RL, Wellington CL, Hackam AS, Propp SS, Wood JD, Sharp AH, Margolis RL, Ross CA, Salvesen GS, Hayden MR, Bredesen DE.
Cleavage of atrophin-1 at caspase site aspartic acid 109 modulates cytotoxicity.
J Biol Chem. 1999 Mar 26;274(13):8730-6. PMID: 10085113
Stennicke HR, Deveraux QL, Humke EW, Reed JC, Dixit VM, Salvesen GS.
Caspase-9 can be activated without proteolytic processing.
J Biol Chem. 1999 Mar 26;274(13):8359-62. PMID: 10085063
Ellerby LM, Hackam AS, Propp SS, Ellerby HM, Rabizadeh S, Cashman NR, Trifiro MA, Pinsky L, Wellington CL, Salvesen GS, Hayden MR, Bredesen DE.
Kennedy's disease: caspase cleavage of the androgen receptor is a crucial event in cytotoxicity.
J Neurochem. 1999 Jan;72(1):185-95. PMID: 9886069
1998 Publications
Amarante-Mendes GP, Finucane DM, Martin SJ, Cotter TG, Salvesen GS, Green DR.
Anti-apoptotic oncogenes prevent caspase-dependent and independent commitment for cell death.
Cell Death Differ. 1998 Apr;5(4):298-306. PMID: 10200475
Miyashita T, Nagao K, Krajewski S, Salvesen GS, Reed JC, Inoue T, Yamada M.
Investigation of glucocorticoid-induced apoptotic pathway: processing of caspase-6 but not caspase-3.
Cell Death Differ. 1998 Dec;5(12):1034-41. PMID: 9894610
Hu S, Snipas SJ, Vincenz C, Salvesen G, Dixit VM.
Caspase-14 is a novel developmentally regulated protease.
J Biol Chem. 1998 Nov 6;273(45):29648-53. PMID: 9792675
Yang X, Stennicke HR, Wang B, Green DR, Janicke RU, Srinivasan A, Seth P, Salvesen GS, Froelich CJ.
Granzyme B mimics apical caspases. Description of a unified pathway for trans-activation of executioner caspase-3 and -7.
J Biol Chem. 1998 Dec 18;273(51):34278-83. PMID: 9852092
Cardone MH, Roy N, Stennicke HR, Salvesen GS, Franke TF, Stanbridge E, Frisch S, Reed JC.
Regulation of cell death protease caspase-9 by phosphorylation.
Science. 1998 Nov 13;282(5392):1318-21. PMID: 9812896
Mehlen P, Rabizadeh S, Snipas SJ, Assa-Munt N, Salvesen GS, Bredesen DE.
The DCC gene product induces apoptosis by a mechanism requiring receptor proteolysis.
Nature. 1998 Oct 22;395(6704):801-4. PMID: 9796814
Stennicke HR, Jurgensmeier JM, Shin H, Deveraux Q, Wolf BB, Yang X, Zhou Q, Ellerby HM, Ellerby LM, Bredesen D, Green DR, Reed JC, Froelich CJ, Salvesen GS.
Pro-caspase-3 is a major physiologic target of caspase-8.
J Biol Chem. 1998 Oct 16;273(42):27084-90. PMID: 9765224
Stennicke HR, Salvesen GS.
Properties of the caspases.
Biochim Biophys Acta. 1998 Sep 8;1387(1-2):17-31. Review. PMID: 9748481
Zhou Q, Krebs JF, Snipas SJ, Price A, Alnemri ES, Tomaselli KJ, Salvesen GS.
Interaction of the baculovirus anti-apoptotic protein p35 with caspases. Specificity, kinetics, and characterization of the caspase/p35 complex.
Biochemistry. 1998 Jul 28;37(30):10757-65. PMID: 9692966
Deveraux QL, Roy N, Stennicke HR, Van Arsdale T, Zhou Q, Srinivasula SM, Alnemri ES, Salvesen GS, Reed JC.
IAPs block apoptotic events induced by caspase-8 and cytochrome c by direct inhibition of distinct caspases.
EMBO J. 1998 Apr 15;17(8):2215-23. PMID: 9545235
Wellington CL, Ellerby LM, Hackam AS, Margolis RL, Trifiro MA, Singaraja R, McCutcheon K, Salvesen GS, Propp SS, Bromm M, Rowland KJ, Zhang T, Rasper D, Roy S, Thornberry N, Pinsky L, Kakizuka A, Ross CA, Nicholson DW, Bredesen DE, Hayden MR.
Caspase cleavage of gene products associated with triplet expansion disorders generates truncated fragments containing the polyglutamine tract.
J Biol Chem. 1998 Apr 10;273(15):9158-67. PMID: 9535906
Takahashi R, Deveraux Q, Tamm I, Welsh K, Assa-Munt N, Salvesen GS, Reed JC.
A single BIR domain of XIAP sufficient for inhibiting caspases.
J Biol Chem. 1998 Apr 3;273(14):7787-90. PMID: 9525868
Amarante-Mendes GP, Finucane DM, Martin SJ, Cotter TG, Salvesen GS, Green DR.
Anti-apoptotic oncogenes prevent caspase-dependent and independent commitment for cell death.
Cell Death Differ. 1998 Apr;5(4):298-306. PMID:10200475
Zapata JM, Takahashi R, Salvesen GS, Reed JC.
Granzyme release and caspase activation in activated human T-lymphocytes.
J Biol Chem. 1998 Mar 20;273(12):6916-20. PMID: 9506996
Muzio M, Stockwell BR, Stennicke HR, Salvesen GS, Dixit VM.
An induced proximity model for caspase-8 activation.
J Biol Chem. 1998 Jan 30;273(5):2926-30. PMID: 9446604
Amarante-Mendes GP, Finucane DM, Martin SJ, Cotter TG, Salvesen GS, Green DR.
Anti-apoptotic oncogenes prevent caspase-dependent and independent commitment for cell death.
Cell Death Differ. 1998 Apr;5(4):298-306. PMID: 10200475
Miyashita T, Nagao K, Krajewski S, Salvesen GS, Reed JC, Inoue T, Yamada M.
Investigation of glucocorticoid-induced apoptotic pathway: processing of caspase-6 but not caspase-3.
Cell Death Differ. 1998 Dec;5(12):1034-41. PMID: 9894610
Hu S, Snipas SJ, Vincenz C, Salvesen G, Dixit VM.
Caspase-14 is a novel developmentally regulated protease.
J Biol Chem. 1998 Nov 6;273(45):29648-53. PMID: 9792675
Yang X, Stennicke HR, Wang B, Green DR, Janicke RU, Srinivasan A, Seth P, Salvesen GS, Froelich CJ.
Granzyme B mimics apical caspases. Description of a unified pathway for trans-activation of executioner caspase-3 and -7.
J Biol Chem. 1998 Dec 18;273(51):34278-83. PMID: 9852092
Cardone MH, Roy N, Stennicke HR, Salvesen GS, Franke TF, Stanbridge E, Frisch S, Reed JC.
Regulation of cell death protease caspase-9 by phosphorylation.
Science. 1998 Nov 13;282(5392):1318-21. PMID: 9812896
Mehlen P, Rabizadeh S, Snipas SJ, Assa-Munt N, Salvesen GS, Bredesen DE.
The DCC gene product induces apoptosis by a mechanism requiring receptor proteolysis.
Nature. 1998 Oct 22;395(6704):801-4. PMID: 9796814
Stennicke HR, Jurgensmeier JM, Shin H, Deveraux Q, Wolf BB, Yang X, Zhou Q, Ellerby HM, Ellerby LM, Bredesen D, Green DR, Reed JC, Froelich CJ, Salvesen GS.
Pro-caspase-3 is a major physiologic target of caspase-8.
J Biol Chem. 1998 Oct 16;273(42):27084-90. PMID: 9765224
Stennicke HR, Salvesen GS.
Properties of the caspases.
Biochim Biophys Acta. 1998 Sep 8;1387(1-2):17-31. Review. PMID: 9748481
Zhou Q, Krebs JF, Snipas SJ, Price A, Alnemri ES, Tomaselli KJ, Salvesen GS.
Interaction of the baculovirus anti-apoptotic protein p35 with caspases. Specificity, kinetics, and characterization of the caspase/p35 complex.
Biochemistry. 1998 Jul 28;37(30):10757-65. PMID: 9692966
Deveraux QL, Roy N, Stennicke HR, Van Arsdale T, Zhou Q, Srinivasula SM, Alnemri ES, Salvesen GS, Reed JC.
IAPs block apoptotic events induced by caspase-8 and cytochrome c by direct inhibition of distinct caspases.
EMBO J. 1998 Apr 15;17(8):2215-23. PMID: 9545235
Wellington CL, Ellerby LM, Hackam AS, Margolis RL, Trifiro MA, Singaraja R, McCutcheon K, Salvesen GS, Propp SS, Bromm M, Rowland KJ, Zhang T, Rasper D, Roy S, Thornberry N, Pinsky L, Kakizuka A, Ross CA, Nicholson DW, Bredesen DE, Hayden MR.
Caspase cleavage of gene products associated with triplet expansion disorders generates truncated fragments containing the polyglutamine tract.
J Biol Chem. 1998 Apr 10;273(15):9158-67. PMID: 9535906
Takahashi R, Deveraux Q, Tamm I, Welsh K, Assa-Munt N, Salvesen GS, Reed JC.
A single BIR domain of XIAP sufficient for inhibiting caspases.
J Biol Chem. 1998 Apr 3;273(14):7787-90. PMID: 9525868
Amarante-Mendes GP, Finucane DM, Martin SJ, Cotter TG, Salvesen GS, Green DR.
Anti-apoptotic oncogenes prevent caspase-dependent and independent commitment for cell death.
Cell Death Differ. 1998 Apr;5(4):298-306. PMID:10200475
Zapata JM, Takahashi R, Salvesen GS, Reed JC.
Granzyme release and caspase activation in activated human T-lymphocytes.
J Biol Chem. 1998 Mar 20;273(12):6916-20. PMID: 9506996
Muzio M, Stockwell BR, Stennicke HR, Salvesen GS, Dixit VM.
An induced proximity model for caspase-8 activation.
J Biol Chem. 1998 Jan 30;273(5):2926-30. PMID: 9446604
1997 Publications
Roy N, Deveraux QL, Takahashi R, Salvesen GS, Reed JC.
The c-IAP-1 and c-IAP-2 proteins are direct inhibitors of specific caspases.
EMBO J. 1997 Dec 1;16(23):6914-25. PMID: 9384571
Salvesen GS.
Serpins and programmed cell death.
Adv Exp Med Biol. 1997;425:177-83. Review. PMID: 9433500
Salvesen GS, Dixit VM.
Caspases: intracellular signaling by proteolysis.
Cell. 1997 Nov 14;91(4):443-6. Review. PMID: 9390553
Stennicke HR, Salvesen GS.
Biochemical characteristics of caspases-3, -6, -7, and -8.
J Biol Chem. 1997 Oct 10;272(41):25719-23. PMID: 9325297
Caulin C, Salvesen GS, Oshima RG.
Caspase cleavage of keratin 18 and reorganization of intermediate filaments during epithelial cell apoptosis.
J Cell Biol. 1997 Sep 22;138(6):1379-94. PMID: 9298992
Ellerby HM, Martin SJ, Ellerby LM, Naiem SS, Rabizadeh S, Salvesen GS, Casiano CA, Cashman NR, Green DR, Bredesen DE.
Establishment of a cell-free system of neuronal apoptosis: comparison of premitochondrial, mitochondrial, and postmitochondrial phases.
J Neurosci. 1997 Aug 15;17(16):6165-78. PMID: 9236228
Cardone MH, Salvesen GS, Widmann C, Johnson G, Frisch SM.
The regulation of anoikis: MEKK-1 activation requires cleavage by caspases.
Cell. 1997 Jul 25;90(2):315-23. PMID: 9244305
Perry DK, Smyth MJ, Stennicke HR, Salvesen GS, Duriez P, Poirier GG, Hannun YA.
Zinc is a potent inhibitor of the apoptotic protease, caspase-3. A novel target for zinc in the inhibition of apoptosis.
J Biol Chem. 1997 Jul 25;272(30):18530-3. PMID: 9228015
Deveraux QL, Takahashi R, Salvesen GS, Reed JC.
X-linked IAP is a direct inhibitor of cell-death proteases.
Nature. 1997 Jul 17;388(6639):300-4. PMID: 9230442
Zhou Q, Salvesen GS.
Activation of pro-caspase-7 by serine proteases includes a non-canonical specificity.
Biochem J. 1997 Jun 1;324 ( Pt 2):361-4. PMID: 9182691
Zhou Q, Snipas S, Orth K, Muzio M, Dixit VM, Salvesen GS.
Target protease specificity of the viral serpin CrmA. Analysis of five caspases.
J Biol Chem. 1997 Mar 21;272(12):7797-800. PMID: 9065443
Muzio M, Salvesen GS, Dixit VM.
FLICE induced apoptosis in a cell-free system. Cleavage of caspase zymogens.
J Biol Chem. 1997 Jan 31;272(5):2952-6. PMID: 9006941
Roy N, Deveraux QL, Takahashi R, Salvesen GS, Reed JC.
The c-IAP-1 and c-IAP-2 proteins are direct inhibitors of specific caspases.
EMBO J. 1997 Dec 1;16(23):6914-25. PMID: 9384571
Salvesen GS.
Serpins and programmed cell death.
Adv Exp Med Biol. 1997;425:177-83. Review. PMID: 9433500
Salvesen GS, Dixit VM.
Caspases: intracellular signaling by proteolysis.
Cell. 1997 Nov 14;91(4):443-6. Review. PMID: 9390553
Stennicke HR, Salvesen GS.
Biochemical characteristics of caspases-3, -6, -7, and -8.
J Biol Chem. 1997 Oct 10;272(41):25719-23. PMID: 9325297
Caulin C, Salvesen GS, Oshima RG.
Caspase cleavage of keratin 18 and reorganization of intermediate filaments during epithelial cell apoptosis.
J Cell Biol. 1997 Sep 22;138(6):1379-94. PMID: 9298992
Ellerby HM, Martin SJ, Ellerby LM, Naiem SS, Rabizadeh S, Salvesen GS, Casiano CA, Cashman NR, Green DR, Bredesen DE.
Establishment of a cell-free system of neuronal apoptosis: comparison of premitochondrial, mitochondrial, and postmitochondrial phases.
J Neurosci. 1997 Aug 15;17(16):6165-78. PMID: 9236228
Cardone MH, Salvesen GS, Widmann C, Johnson G, Frisch SM.
The regulation of anoikis: MEKK-1 activation requires cleavage by caspases.
Cell. 1997 Jul 25;90(2):315-23. PMID: 9244305
Perry DK, Smyth MJ, Stennicke HR, Salvesen GS, Duriez P, Poirier GG, Hannun YA.
Zinc is a potent inhibitor of the apoptotic protease, caspase-3. A novel target for zinc in the inhibition of apoptosis.
J Biol Chem. 1997 Jul 25;272(30):18530-3. PMID: 9228015
Deveraux QL, Takahashi R, Salvesen GS, Reed JC.
X-linked IAP is a direct inhibitor of cell-death proteases.
Nature. 1997 Jul 17;388(6639):300-4. PMID: 9230442
Zhou Q, Salvesen GS.
Activation of pro-caspase-7 by serine proteases includes a non-canonical specificity.
Biochem J. 1997 Jun 1;324 ( Pt 2):361-4. PMID: 9182691
Zhou Q, Snipas S, Orth K, Muzio M, Dixit VM, Salvesen GS.
Target protease specificity of the viral serpin CrmA. Analysis of five caspases.
J Biol Chem. 1997 Mar 21;272(12):7797-800. PMID: 9065443
Muzio M, Salvesen GS, Dixit VM.
FLICE induced apoptosis in a cell-free system. Cleavage of caspase zymogens.
J Biol Chem. 1997 Jan 31;272(5):2952-6. PMID: 9006941
1996 Publications
Koloczek H, Banbula A, Salvesen GS, Potempa J.
Serpin alpha 1proteinase inhibitor probed by intrinsic tryptophan fluorescence spectroscopy.
Protein Sci. 1996 Nov;5(11):2226-35. PMID: 8931141
Froelich CJ, Hanna WL, Poirier GG, Duriez PJ, D'Amours D, Salvesen GS, Alnemri ES, Earnshaw WC, Shah GM.
Granzyme B/perforin-mediated apoptosis of Jurkat cells results in cleavage of poly(ADP-ribose) polymerase to the 89-kDa apoptotic fragment and less abundant 64-kDa fragment.
Biochem Biophys Res Commun. 1996 Oct 23;227(3):658-65. PMID: 8885990
Alnemri ES, Livingston DJ, Nicholson DW, Salvesen G, Thornberry NA, Wong WW, Yuan J.
Human ICE/CED-3 protease nomenclature.
Cell. 1996 Oct 18;87(2):171. PMID:8861900
Orth K, O'Rourke K, Salvesen GS, Dixit VM.
Molecular ordering of apoptotic mammalian CED-3/ICE-like proteases.
J Biol Chem. 1996 Aug 30;271(35):20977-80. PMID: 8702858
Komiyama T, Gron H, Pemberton PA, Salvesen GS.
Interaction of subtilisins with serpins.
Protein Sci. 1996 May;5(5):874-82. PMID: 8732759
Quan LT, Tewari M, O'Rourke K, Dixit V, Snipas SJ, Poirier GG, Ray C, Pickup DJ, Salvesen GS.
Proteolytic activation of the cell death protease Yama/CPP32 by granzyme B.
Proc Natl Acad Sci U S A. 1996 Mar 5;93(5):1972-6. PMID: 8700869
Komiyama T, Quan LT, Salvesen GS.
Inhibition of cysteine and serine proteinases by the cowpox virus serpin CRMA.
Adv Exp Med Biol. 1996;389:173-6. Review. PMID: 8861008
Koloczek H, Banbula A, Salvesen GS, Potempa J.
Serpin alpha 1proteinase inhibitor probed by intrinsic tryptophan fluorescence spectroscopy.
Protein Sci. 1996 Nov;5(11):2226-35. PMID: 8931141
Froelich CJ, Hanna WL, Poirier GG, Duriez PJ, D'Amours D, Salvesen GS, Alnemri ES, Earnshaw WC, Shah GM.
Granzyme B/perforin-mediated apoptosis of Jurkat cells results in cleavage of poly(ADP-ribose) polymerase to the 89-kDa apoptotic fragment and less abundant 64-kDa fragment.
Biochem Biophys Res Commun. 1996 Oct 23;227(3):658-65. PMID: 8885990
Alnemri ES, Livingston DJ, Nicholson DW, Salvesen G, Thornberry NA, Wong WW, Yuan J.
Human ICE/CED-3 protease nomenclature.
Cell. 1996 Oct 18;87(2):171. PMID:8861900
Orth K, O'Rourke K, Salvesen GS, Dixit VM.
Molecular ordering of apoptotic mammalian CED-3/ICE-like proteases.
J Biol Chem. 1996 Aug 30;271(35):20977-80. PMID: 8702858
Komiyama T, Gron H, Pemberton PA, Salvesen GS.
Interaction of subtilisins with serpins.
Protein Sci. 1996 May;5(5):874-82. PMID: 8732759
Quan LT, Tewari M, O'Rourke K, Dixit V, Snipas SJ, Poirier GG, Ray C, Pickup DJ, Salvesen GS.
Proteolytic activation of the cell death protease Yama/CPP32 by granzyme B.
Proc Natl Acad Sci U S A. 1996 Mar 5;93(5):1972-6. PMID: 8700869
Komiyama T, Quan LT, Salvesen GS.
Inhibition of cysteine and serine proteinases by the cowpox virus serpin CRMA.
Adv Exp Med Biol. 1996;389:173-6. Review. PMID: 8861008
1995 Publications
Tewari M, Quan LT, O'Rourke K, Desnoyers S, Zeng Z, Beidler DR, Poirier GG, Salvesen GS, Dixit VM.
Yama/CPP32 beta, a mammalian homolog of CED-3, is a CrmA-inhibitable protease that cleaves the death substrate poly(ADP-ribose) polymerase.
Cell. 1995 Jun 2;81(5):801-9. PMID: 7774019
Quan LT, Caputo A, Bleackley RC, Pickup DJ, Salvesen GS.
Granzyme B is inhibited by the cowpox virus serpin cytokine response modifier A.
J Biol Chem. 1995 May 5;270(18):10377-9. PMID: 7737968
Tewari M, Quan LT, O'Rourke K, Desnoyers S, Zeng Z, Beidler DR, Poirier GG, Salvesen GS, Dixit VM.
Yama/CPP32 beta, a mammalian homolog of CED-3, is a CrmA-inhibitable protease that cleaves the death substrate poly(ADP-ribose) polymerase.
Cell. 1995 Jun 2;81(5):801-9. PMID: 7774019
Quan LT, Caputo A, Bleackley RC, Pickup DJ, Salvesen GS.
Granzyme B is inhibited by the cowpox virus serpin cytokine response modifier A.
J Biol Chem. 1995 May 5;270(18):10377-9. PMID: 7737968
1993 Publications
Strittmatter WJ, Weisgraber KH, Huang DY, Dong LM, Salvesen GS, Pericak-Vance M, Schmechel D, Saunders AM, Goldgaber D, Roses AD.
Binding of human apolipoprotein E to synthetic amyloid beta peptide: isoform-specific effects and implications for late-onset Alzheimer disease.
Proc Natl Acad Sci U S A. 1993 Sep 1;90(17):8098-102. PMID: 8367470
Strittmatter WJ, Saunders AM, Schmechel D, Pericak-Vance M, Enghild J, Salvesen GS, Roses AD.
Apolipoprotein E: high-avidity binding to beta-amyloid and increased frequency of type 4 allele in late-onset familial Alzheimer disease.
Proc Natl Acad Sci U S A. 1993 Mar 1;90(5):1977-81. PMID: 8446617
Strittmatter WJ, Weisgraber KH, Huang DY, Dong LM, Salvesen GS, Pericak-Vance M, Schmechel D, Saunders AM, Goldgaber D, Roses AD.
Binding of human apolipoprotein E to synthetic amyloid beta peptide: isoform-specific effects and implications for late-onset Alzheimer disease.
Proc Natl Acad Sci U S A. 1993 Sep 1;90(17):8098-102. PMID: 8367470
Strittmatter WJ, Saunders AM, Schmechel D, Pericak-Vance M, Enghild J, Salvesen GS, Roses AD.
Apolipoprotein E: high-avidity binding to beta-amyloid and increased frequency of type 4 allele in late-onset familial Alzheimer disease.
Proc Natl Acad Sci U S A. 1993 Mar 1;90(5):1977-81. PMID: 8446617
1992 Publications
Ray CA, Black RA, Kronheim SR, Greenstreet TA, Sleath PR, Salvesen GS, Pickup DJ.
Viral inhibition of inflammation: cowpox virus encodes an inhibitor of the interleukin-1 beta converting enzyme.
Cell. 1992 May 15;69(4):597-604. PMID: 1339309
Salvesen G, Quan LT, Enghild JJ, Snipas S, Fey GH, Pizzo SV.
Expression of a functional alpha-macroglobulin receptor binding domain in Escherichia coli.
FEBS Lett. 1992 Nov 23;313(2):198-202. PMID: 1385222
Ray CA, Black RA, Kronheim SR, Greenstreet TA, Sleath PR, Salvesen GS, Pickup DJ.
Viral inhibition of inflammation: cowpox virus encodes an inhibitor of the interleukin-1 beta converting enzyme.
Cell. 1992 May 15;69(4):597-604. PMID: 1339309
Salvesen G, Quan LT, Enghild JJ, Snipas S, Fey GH, Pizzo SV.
Expression of a functional alpha-macroglobulin receptor binding domain in Escherichia coli.
FEBS Lett. 1992 Nov 23;313(2):198-202. PMID: 1385222